Index Catalog // ScholarsArchive@OSU

Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

Creator:: Wang, Jing
Abstract:: Dysfunction of mitochondria has been linked to aging and the pathogenesis of many degenerative diseases. Aside from their primary function in energy production, mitochondria are considered as a major source and target of reactive oxygen and nitrogen species (ROS/RNS) in cells as well. The mitochondrial thiol proteome is a subset...
Resource Type:: Dissertation
Full Text:: mitochondrial thiol proteome is a subset of proteins inside mitochondria particularly vulnerable to oxidative

Prospective Evaluation of the Lymph Node Proteome in Dogs with Multicentric Lymphoma Supplemented with Sulforaphane

Creator:: Parachini-Winter, Cyril
Abstract:: Lymphoma (LSA) is one of the most common canine malignancies, and is almost invariably a terminal disease. Epigenetic changes in canine and human lymphomas have been linked to disease progression and poor prognosis, leading to the development of epigenetic-targeted therapies which have shown promise in treating various forms of human...
Resource Type:: Masters Thesis
Full Text:: . Title: Prospective Evaluation of the Lymph Node Proteome in Dogs with Multicentric Lymphoma

Advanced Mass Spectrometry Techniques for Characterizations of Proteome and Lipidome Profiles of Osteosarcoma Cells

Creator:: Song, Zifeng
Abstract:: Mass Spectrometry has emerged as an analytical core technique in omics sciences, in particularly mass spectrometry has advanced the fields of proteomics, metabolomics and lipidomics in recent years. Mass spectrometric techniques have enabled the characterization and determination of abundance levels of a wide range of biomolecules at molecular and system-wide...
Resource Type:: Dissertation
Full Text:: Spectrometry Techniques for Characterizations of Proteome and Lipidome Profiles of Osteosarcoma Cells

Quantitative Analysis of Mycobacterium avium subsp. hominissuis and Mycobacterium abscessus subs. abscessus Proteome in Response to Antibiotics and During Exposure to Different Environmental Conditions

Creator:: Rojony, Rajoana
Abstract:: M. avium subsp. hominissuis (MAH) and M. abscessus subsp. abscessus (MAB) both belong to the clinically important non-tuberculous mycobacterial (NTM) group that infect immunocompromised patients with AIDS and individuals with underlining lung conditions such as bronchiectasis or cystic fibrosis. The main challenge of treating MAH and MAB patients is an...
Resource Type:: Masters Thesis
Full Text:: of Master of Science in Comparative Health Sciences presented on August 1, 2019. Title

Label-free mass spectrometry-driven methods for elucidating adaptive responses of the hepatic mitochondrial proteome in an alcoholic fatty liver disease model

Creator:: Tzeng, Shin-Cheng
Abstract:: Alcoholic liver disease (ALD) continues to be one of the major public health problems in the United States and worldwide. Complicated by factors including gender, polymorphisms of alcohol-metabolizing enzymes, immunologic factors, exposures to other substances/drugs, hepatic viral infections, nutritional deficiencies, and obesity, ALD is a complex disease that requires a...
Resource Type:: Dissertation
Full Text:: Elucidating Adaptive Responses of the Hepatic Mitochondrial Proteome in an Alcoholic Fatty Liver Disease Model

The Genetics of Larval Fitness in the Pacific Oyster: Responses to Acidified Seawater and Temporally Dynamic Selection Processes

Creator:: Durland, Evan R.
Abstract:: The Pacific Oyster (Crassostrea gigas) is one of the most economically and ecologically significant shellfish species worldwide. In the Pacific Northwest United States (PNW), the sustainability oyster stocks is increasingly threatened by ocean acidification (OA), which has had significant negative effects on the aquaculture industry in this region over the...
Resource Type:: Dissertation
Full Text:: for the degree of Doctor of Philosophy in Fisheries Science presented on May 14, 2019. Title

Deciphering the Function of New Gonorrhea Vaccine Candidates in Cell Envelope Homeostasis

Creator:: Baarda, Benjamin I.
Abstract:: Neisseria gonorrhoeae is the sexually transmitted pathogen responsible for millions of cases of gonorrhea worldwide each year. Rapidly-spreading antibiotic resistance is diminishing the ability to effectively treat a disease with significant consequences to female and male reproductive health, as well as to neonatal well-being. A protective vaccine has the potential...
Resource Type:: Dissertation
Full Text:: challenged by the gonococcus’s tremendous modulation of its surface proteome, evasion of immune responses

Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

Creator:: McNamara, Michael J.
Abstract:: Mycobacterium avium subsp. hominissuis (MAH) is a pervasive environmental bacterium that can cause opportunistic infections in humans. Among the most robust and hardy members of the Mycobacterium genus, M. avium can persist and thrive in a range of challenging environments, including many which place it in direct contact with humans....
Resource Type:: Dissertation
Full Text:: to more thoroughly characterize the surface-exposed proteome of M. avium, particularly in the

Proteomic analyses of marine bacteria

Creator:: Sowell, Sarah M.
Abstract:: Proteins are the metabolic machines of the cell and as such, the study of proteins could illuminate the dominant biological activities that are occurring within cells and reveal how an organism interacts with its environment. Here, we used proteomic techniques to study the abundant marine bacterium SAR11 both as an...
Resource Type:: Dissertation
Full Text:: devoting significant resources to proteome remodeling. A mechanism for a global stationary-phase response

The Effect of Non-Steroidal Anti-Inflammatory Drugs on Canine Transitional Cell Carcinoma and Its Correlation with Cyclooxygenase-2 Expression

Creator:: Weinman, Marcus Andrew
Abstract:: Canine transitional cell carcinoma (TCC) has been shown to have a substantial inflammatory component. It exhibits genotypic and morphologic elements that resemble its human counterpart. Cyclooxygenases (COX) are key enzymes in the synthesis of proinflammatory molecules, such as prostaglandins. Excess prostaglandin production through cyclooxygenases may promote oncogenesis and progression of...
Resource Type:: Honors College Thesis
Full Text:: requirements for the degree of Honors Baccalaureate of Science in Microbiology (Honors Scholar

ScholarsArchive@OSU

Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

Prospective Evaluation of the Lymph Node Proteome in Dogs with Multicentric Lymphoma Supplemented with Sulforaphane

Advanced Mass Spectrometry Techniques for Characterizations of Proteome and Lipidome Profiles of Osteosarcoma Cells

Quantitative Analysis of Mycobacterium avium subsp. hominissuis and Mycobacterium abscessus subs. abscessus Proteome in Response to Antibiotics and During Exposure to Different Environmental Conditions

Label-free mass spectrometry-driven methods for elucidating adaptive responses of the hepatic mitochondrial proteome in an alcoholic fatty liver disease model

The Genetics of Larval Fitness in the Pacific Oyster: Responses to Acidified Seawater and Temporally Dynamic Selection Processes

Deciphering the Function of New Gonorrhea Vaccine Candidates in Cell Envelope Homeostasis

Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

Proteomic analyses of marine bacteria

The Effect of Non-Steroidal Anti-Inflammatory Drugs on Canine Transitional Cell Carcinoma and Its Correlation with Cyclooxygenase-2 Expression

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