Index Catalog // ScholarsArchive@OSU

Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop

Creator:: Adams, Paul D., Aertgeerts, Kathleen, Bauer, Cary, Bell, Jeffrey A., Berman, Helen M., Bhat, Talapady N., Blaney, Jeff M., Bolton, Evan, Bricogne, Gerard, Brown, David, Burley, Stephen K., Case, David A., Clark, Kirk L., Darden, Tom, Emsley, Paul, Feher, Victoria A., Feng, Zukang, Groom, Colin R., Harris, Seth F., Hendle, Jorg, Holder, Thomas, Joachimiak, Andrzej, Kleywegt, Gerard J., Krojer, Tobias, Marcotrigiano, Joseph, Mark, Alan E., Markley, John L., Miller, Matthew, Minor, Wladek, Montelione, Gaetano T., Murshudov, Garib, Nakagawa, Atsushi, Nakamura, Haruki, Nicholls, Anthony, Nicklaus, Marc, Nolte, Robert T., Padyana, Anil K., Peishoff, Catherine E., Pieniazek, Susan, Read, Randy J., Shao, Chenghua, Sheriff, Steven, Smart, Oliver, Soisson, Stephen, Spurlino, John, Stouch, Terry, Svobodova, Radka, Tempel, Wolfram, Terwilliger, Thomas C., Tronrud, Dale, Velankar, Sameer, Ward, Suzanna C., Warren, Gregory L., Westbrook, John D., Williams, Pamela, Yang, Huanwang, and Young, Jasmine
Abstract:: Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Resource Type:: Article

Quantification and reactivity of cellulose reducing ends : implication for cellulose

Creator:: Kongruang, Sasithorn
Abstract:: The primary purpose of this study was to (1) develop methods for the analysis of and (2) provide information on the chemical nature of reducing ends in typical cellulose substrates used for the study of cellulolytic enzymes. The studies were designed such that values obtained for cellulose substrates were compared...
Resource Type:: Dissertation
Full Text:: appreciation to Dr. Rosalyn Upson, Dr. John P. Bolte and Dr. John J. Garland as committee members. I am proud

Incorporating Uncertainty in Truckload Relay Network Design

Creator:: Mokhtari, Zahra
Abstract:: In a relay network for full truckload (TL) transportation, facilities known as relay points (RPs) serve as exchange points where truck drivers can exchange trailers. This would help carriers to assign more regular tours to drivers when compared to the excessively long tours that exist in the traditional Point-to-Point (PtP)...
Resource Type:: Dissertation
Full Text:: where a load is transported from node i to node j using three RPs. Figure 1: Example of a

Biophysical analyses of peroxiredoxins and a partner reductase

Creator:: Hall, Andrea Renée
Abstract:: Peroxiredoxins (Prxs) are dominant peroxide-reducing enzymes with two important roles: they protect all organisms from oxidative damage induced by peroxides, and in eukaryotes, they participate in hydrogen peroxide signaling pathways. This dissertation presents studies aimed at the biophysical characterization of select Prxs and a Prx reductase to elucidate their structure-function...
Resource Type:: Dissertation
Full Text:: and hemoglobin, awarded to J. C. Kendrew, M. Perutz), there have been 16 Nobel Prizes in chemistry

Sequence dependent conformational variations in DNA holliday junctions

Creator:: Hays, Franklin A.
Abstract:: Four-stranded DNA junctions (also known as Holliday junctions) are structural intermediates involved in a growing number of biological processes including DNA repair, genetic recombination, and viral integration. Although previous studies have focused on understanding the conformational variability and sequence-dependent formation of Holliday junctions in solution there have been relatively few...
Resource Type:: Dissertation
Full Text:: role in the subsequent structure solution and refinement. Zebulon J. R. Jones provided some assistance

Operations Research Models for Blood Supply Chain Network Design for Disaster Planning

Creator:: Baik, Shefaa A.
Abstract:: A blood supply chain (BSC) deals with the collection, processing, storing, and distribution of blood collected from donors and delivered to patients at demand points (DPs) through a network of several temporary mobile blood units (MBUs) and permanent local blood centers (LBCs). In general, the strategic and tactical design of...
Resource Type:: Dissertation
Full Text:: different values of J and N. ...................................... 115 Figure 5.3: Variance of optimality

Crystallographic studies of Pyrenophora tritici-repentis ToxA

Creator:: Sarma, Ganapathy N.
Abstract:: Tan spot of wheat is an economically significant disease caused by the fungal pathogen, Pyrenophora tritici-repentis. Certain races of the fungus secrete Ptr ToxA (ToxA), a 13.2 kDa proteinaceous host-selective toxin that is responsible and sufficient to cause disease in susceptible wheat varieties. Disease symptoms develop only when the ToxA...
Resource Type:: Dissertation
Full Text:: -wheat interaction. Phytopathology 89, 444-449. 16 6. De Wolf, E. D., Effertz, R. J., Au, S. & Franci

Preparation and modification of cellooligosaccharides

Creator:: Akpinar, Ozlem
Abstract:: Cellooligosaccharides are the reaction intermediates produced during the hydrolysis of cellulose to glucose. Hence, they have the same chemical structure as cellulose, just shorter chain lengths. Cellooligosaccharides up to DP eight are soluble in water. The soluble cellooligosaccharides can be used "as is" in the food industry as non-digestible oligosaccharides...
Resource Type:: Dissertation
Full Text:: . Michael H. Penner, for his time and support throughout my study. I owe special thanks to Dr. Robert J

Modeling protein structure at atomic resolution

Creator:: Berkholz, Donald S.
Abstract:: This thesis includes three studies involving different aspects of modeling protein structure. The first study illustrates the levels of insight available from atomic-resolution protein structures. The second study derives general trends of protein geometry from atomic-resolution structures and shows their implications for modeling. The third study creates a model of...
Resource Type:: Dissertation
Full Text:: glutathione reductase near 1 A resolution. J. Mol. Biol. 382, 371-384. Bradley, P., Misura, K.M.S., and

Learning based methods applied to the MAV control problem

Creator:: Salichon, Max
Abstract:: This thesis addresses Micro Aerial Vehicle (MAV) control by leveraging learning based techniques to improve robustness of the control system. Applying classical control methods to MAVs is a difficult process due to the complexity of the control laws with fast and highly non-linear dynamics. These methods are mostly based on...
Resource Type:: Dissertation

ScholarsArchive@OSU

Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop

Quantification and reactivity of cellulose reducing ends : implication for cellulose

Incorporating Uncertainty in Truckload Relay Network Design

Biophysical analyses of peroxiredoxins and a partner reductase

Sequence dependent conformational variations in DNA holliday junctions

Operations Research Models for Blood Supply Chain Network Design for Disaster Planning

Crystallographic studies of Pyrenophora tritici-repentis ToxA

Preparation and modification of cellooligosaccharides

Modeling protein structure at atomic resolution

Learning based methods applied to the MAV control problem

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