Index Catalog // ScholarsArchive@OSU

Label-free mass spectrometry-driven methods for elucidating adaptive responses of the hepatic mitochondrial proteome in an alcoholic fatty liver disease model

Creator:: Tzeng, Shin-Cheng
Abstract:: Alcoholic liver disease (ALD) continues to be one of the major public health problems in the United States and worldwide. Complicated by factors including gender, polymorphisms of alcohol-metabolizing enzymes, immunologic factors, exposures to other substances/drugs, hepatic viral infections, nutritional deficiencies, and obesity, ALD is a complex disease that requires a...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Shin-Cheng Tzeng for the degree of Doctor of Philosophy in

Label-Free Proteomics Assisted by Affinity Enrichment for Elucidating the Chemical Reactivity of the Liver Mitochondrial Proteome toward Adduction by the Lipid Electrophile 4-hydroxy-2-nonenal (HNE)

Creator:: Tzeng, Shin-Cheng and Maier, Claudia S.
Abstract:: The analysis of oxidative stress-induced post-translational modifications remains challenging due to the chemical diversity of these modifications, the possibility of the presence of positional isomers and the low stoichiometry of the modified proteins present in a cell or tissue proteome. Alcoholic liver disease (ALD) is a multifactorial disease in which...
Resource Type:: Article
Full Text:: 4-hydroxy-2-nonenal (HNE) Shin-Cheng Tzeng † and Claudia S. Maier * Department of Chemistry, Oregon

Surface-exposed proteins of pathogenic mycobacteria and the role of cu-zn superoxide dismutase in macrophages and neutrophil survival

Creator:: McNamara, Michael, Tzeng, Shin-Cheng, Maier, Claudia, Wu, Martin, and Bermudez, Luiz E.
Abstract:: Pathogenic mycobacteria are important agents causing human disease. Mycobacterium avium subsp. hominissuis (M. avium) is a species of recalcitrant environmental pathogen. The bacterium forms robust biofilms that allow it to colonize and persist in austere environments, such as residential and commercial water systems. M. avium is also an opportunistic pathogen...
Resource Type:: Article

Protein modifications by electrophilic lipoxidation products: Adduct formation, chemical strategies and tandem mass spectrometry for their detection and identification

Creator:: Vasil'ev, Yury V., Tzeng, Shin-Chen, Huang, Lin, and Maier, Claudia S.
Abstract:: The post-translational modification of proteins by electrophilic oxylipids is emerging as an important mechanism that contributes to the complexity of proteomes. Enzymatic and non-enzymatic oxidation of biological lipids results in the formation of chemically diverse electrophilic carbonyl compounds, such as 2-alkenals and 4-hydroxy alkenals, epoxides and eicosanoids with reactive cyclopentenone...
Resource Type:: Article

Salmon plasma protein to inhibit protease enzymes and enhance surimi gelation

Creator:: Fowler, Matthew
Abstract:: The ability of salmon plasma protein (SPP) obtained from Chinook salmon at the Klaskanine Fish Hatchery (Astoria, OR) to inhibit protease enzymes found in Pacific whiting (PW) surimi and salmon mince as well as the effect of SPP on the gelation properties of PW surimi under various heating conditions was...
Resource Type:: Masters Thesis
Full Text:: and cathepsin L but not trypsin (Lee, Tzeng, & Jiang, 2000) and a fraction was found from chicken

Bioinformatics applied to freshwater cyanobacterial blooms and cyanophage

Creator:: Schwartz, Andrew D.
Abstract:: Freshwater cyanobacterial blooms are a nuisance and health threat in the Pacific Northwest. The accepted methods of characterizing these blooms by microscopic cell counts cannot differentiate between toxic and non-toxic strains of the cyanobacterium Microcystis. Also, there is limited understanding of freshwater cyanophage that may control bloom dynamics. In order...
Resource Type:: Masters Thesis
Full Text:: . Bennett, Shin-Cheng Tzeng and Dr. Claudia Maier all worked with our lab to obtain excellent mass

Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

Creator:: McNamara, Michael J.
Abstract:: Mycobacterium avium subsp. hominissuis (MAH) is a pervasive environmental bacterium that can cause opportunistic infections in humans. Among the most robust and hardy members of the Mycobacterium genus, M. avium can persist and thrive in a range of challenging environments, including many which place it in direct contact with humans....
Resource Type:: Dissertation
Full Text:: for M. avium. Shin-Cheng Tzeng, Li Zhang, Claudia Maier and Luiz Bermudez assisted with

Factors Associated with body mass index among young adults in Taiwan

Creator:: Lai, I-Ju
Abstract:: Obesity is a major public health problem and is a risk factor for hypertension, diabetes, heart disease and cancer. In addition, the prevalence of obesity appears to be increasing worldwide, making it important to determine the nature and extent of obesity in populations at risk. The aim of this study...
Resource Type:: Masters Thesis
Full Text:: chronic diseases has been documented in the literature (WHO 1998; Ng, Kim-choy, Lin, Cheng-chieh, Lai

Investigation of bipolar resistive switching in zinc-tin-oxide for resistive random access memory

Creator:: Murali, Santosh
Abstract:: Resistive random access memory (RRAM) is a non-volatile memory technology based on resistive switching in a dielectric or semiconductor sandwiched between two different metals. Also known as memristors, these devices are potential candidates for a next-generation replacement for flash memory. In this thesis, bipolar resistive switching is reported for the...
Resource Type:: Masters Thesis

Identifying and Removing On-chip Network Bottleneck in Throughput Processors

Creator:: Li, Yunfan
Abstract:: The high level of parallelism in throughput processors such as GPGPUs has resulted in significantly changed on-chip data traffic behaviors. This demands new research to identify and address the limiting factors of networks-on-chip (NoCs) in the context of throughput processors. In this work, we ﬁrst quantitatively analyze the performance of...
Resource Type:: Masters Thesis

ScholarsArchive@OSU

Label-free mass spectrometry-driven methods for elucidating adaptive responses of the hepatic mitochondrial proteome in an alcoholic fatty liver disease model

Label-Free Proteomics Assisted by Affinity Enrichment for Elucidating the Chemical Reactivity of the Liver Mitochondrial Proteome toward Adduction by the Lipid Electrophile 4-hydroxy-2-nonenal (HNE)

Surface-exposed proteins of pathogenic mycobacteria and the role of cu-zn superoxide dismutase in macrophages and neutrophil survival

Protein modifications by electrophilic lipoxidation products: Adduct formation, chemical strategies and tandem mass spectrometry for their detection and identification

Salmon plasma protein to inhibit protease enzymes and enhance surimi gelation

Bioinformatics applied to freshwater cyanobacterial blooms and cyanophage

Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

Factors Associated with body mass index among young adults in Taiwan

Investigation of bipolar resistive switching in zinc-tin-oxide for resistive random access memory

Identifying and Removing On-chip Network Bottleneck in Throughput Processors

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