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Filtering by: Language English [eng] Subject Biological models

Application of a Modified Microdosimetric-Kinetic Model to Analyze Cell Killing in Determination of the Optimal Particle for Light Ion Therapy

Creator:

Butkus, Michael P.

Abstract:

Ion therapy has long been investigated as a potential modality to improve cancer treatments beyond what is currently feasible with photon irradiations. Ions offer both a physical and biological advantage over photons. The physical advantages are well understood, ions deposit their maximum dose at defined penetration depths, allowing for minimal...

Resource Type:

Dissertation
Sensitivity analysis as "propagation of error" and model validation

Creator:

Overton, W. Scott

Abstract:

Conclusion: The first part of this note deals with problems of propagation of error and the latter part with questions commonly identified as "model validation" questions. It is concluded that all validation questions can be resolved into two parts: (1) strategic aspects, involving logical and inferential structures and (2) tactical...

Resource Type:

Technical Report