Index Catalog // ScholarsArchive@OSU

Ibuprofen Treatment Causes NMDA and AMPA Receptor Hyperactivity in Female Wild Type and Heterozygous 5xFAD mice but not Males

Creator:: Rauenhorst, Jacob
Abstract:: With Alzheimer’s disease being the most prominent form of dementia, finding potential treatments for the disease is imperative. This study explored the non-steroidal anti-inflammatory drug ibuprofen as a potential treatment to normalize the hyperactive N-methyl-d-aspartate receptor (NMDAR) within the 5xFAD mice early in the disease pathology before cognitive decline. Female...
Resource Type:: Honors College Thesis
Full Text:: /d0md00196a. (39) Marquez Loza, A.; Elias, V.; Wong, C. P.; Ho, E.; Bermudez, M.; Magnusson, K. R. Effects of

Pressure effects on density-difference driven stratified flow : CFD model of DCC event in the HTGR

Creator:: Magnusson, Jill E.
Abstract:: In a Modular High Temperature Gas Reactor (MHTGR), the Depressurized Conduction Cooldown (DCC) event can be separated into three distinct stages: 1) depressurization, 2) air ingress and, 3) natural circulation. During normal operations, the HTGR utilizes forced convection to move the helium coolant through the reactor core. Thus, during normal...
Resource Type:: Masters Thesis
Full Text:: . Magnusson for the degree of Master of Science in Nuclear Engineering presented on Title: June 3, 2011

A pro-inflammatory agent, Lipopolysaccharide, can mimic the effects ofaging on spatial reference memory

Creator:: Escobedo, Emily R. and Magnusson, Kathy R.
Abstract:: A pro-inflammatory agent, lipopolysaccharide, can mimic the effects of aging on spatial reference memory E. R. ESCOBEDO and K. R. Magnusson, Dept. of Biomedical Sciences, Coll. of Vet. Med., Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 Humans and rodents experience declines in reference (long-term), working (short-term) memory, and...
Resource Type:: Poster

The effects of enhanced expression of the GluN2B (NR2B) subunit of the N-methyl-D-aspartate (NMDA) receptor on memory in aged animals

Creator:: Brim, Brenna L.
Abstract:: As the aging population continues to grow worldwide, age-related complications are becoming more apparent within the aging population. One of the first age-related complications to become apparent is age-associated memory impairment and it can make the elderly more dependent on caregivers early on. The N-methyl-D-aspartate (NMDA) receptor is important to...
Resource Type:: Dissertation
Full Text:: . L. Brim, R. Haskell, R. Awedikian, N.M. Ellinwood, L. Jin, K. Magnusson. . Chapter III

Cannabidiol Effects on NMDA and AMPA Receptor Activity and Cognitive Function at a High Dose in 5xFAD Mice

Creator:: Sackinger, Emily P.
Abstract:: Alzheimer’s Disease (AD) is an abnormal part of aging that mainly affects those over the age of 65. The current therapies are only FDA approved for mild to moderate AD symptoms. Cannabidiol (CBD) is a non-intoxicating constituent of Cannabis sativa that has been shown to have beneficial effects on cancer,...
Resource Type:: Masters Thesis
Full Text:: Abstract approved: ______________________________________________________ Kathy R. Magnusson

Age-related differences in brain activations during spatial memory formation in a virtual Morris water maze task

Creator:: Reynolds-Lallement, Nadjalisse C.
Abstract:: This study applied a virtual rendition of the Morris water maze, which is commonly used for assessing spatial memory in rodents, to an examination of age-related differences in spatial learning among 42 younger (18-30 years) and older (>60 years) male human participants. Virtual Morris water maze performance was measured by...
Resource Type:: Honors College Thesis
Full Text:: . Abstract approved: Kathy Magnusson This study applied a virtual rendition of the

Influence of aging and behavioral experience on expression of GluN1 splice variants of the NMDA receptor in prefrontal cortex of mice brain

Creator:: Das, Siba Ranjan
Abstract:: As the aging population continues to grow the world over, age related complications become more and more apparent among the elderly population. One such complication is age associated memory impairment, which makes the elderly more dependent on caregivers early on. NMDA receptors in the brain are important for memory formation,...
Resource Type:: Dissertation
Full Text:: : _____________________________________________________________________ Kathy R. Magnusson As the aging population continues to grow the world over, age related

Mechanisms that influence the posttranslational modification of the GluN2B subunit in the aged brain

Creator:: Zamzow, Daniel R.
Abstract:: Memory is essential to everyday life. As we age, deficits in memory become apparent. The toll of age-related cognitive impairment can be devastating to families and costly to society. The NMDA receptor is a molecule in the brain that is instrumental in the formation of memories. The receptor is particularly...
Resource Type:: Dissertation
Full Text:: Kathy R. Magnusson Memory is essential to everyday life. As we age, deficits in memory become

Effects of age and military service on memory and cognitive flexibility in a virtual Morris water maze task

Creator:: Mollusky, Adina J.
Abstract:: This study applied a virtual version of the Morris water maze (vMWM) task to an examination of age-related differences between younger and older participants, and the impact of prior military service in older men on spatial memory and cognitive flexibility. Participants performed the Logical Memory task that included immediate and...
Resource Type:: Honors College Thesis
Full Text:: Kathy Magnusson This study applied a virtual version of the Morris water maze (vMWM) task to an

The Role of Nrf2 in Brain Cellular Senescence

Creator:: Ross, Grace K.
Abstract:: Aging is a major risk factor for the deterioration of biochemical pathways that lead to many chronic neurodegenerative disorders (i.e. Parkinson’s and Alzheimer's Disease). Cellular senescence is a hallmark of aging, a condition characterized by stable growth arrest resulting in a cell that no longer divides, but is metabolically active....
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kathy Magnusson, Committee Member, representing Biomedical Sciences, College of Veterinary

ScholarsArchive@OSU

Ibuprofen Treatment Causes NMDA and AMPA Receptor Hyperactivity in Female Wild Type and Heterozygous 5xFAD mice but not Males

Pressure effects on density-difference driven stratified flow : CFD model of DCC event in the HTGR

A pro-inflammatory agent, Lipopolysaccharide, can mimic the effects ofaging on spatial reference memory

The effects of enhanced expression of the GluN2B (NR2B) subunit of the N-methyl-D-aspartate (NMDA) receptor on memory in aged animals

Cannabidiol Effects on NMDA and AMPA Receptor Activity and Cognitive Function at a High Dose in 5xFAD Mice

Age-related differences in brain activations during spatial memory formation in a virtual Morris water maze task

Influence of aging and behavioral experience on expression of GluN1 splice variants of the NMDA receptor in prefrontal cortex of mice brain

Mechanisms that influence the posttranslational modification of the GluN2B subunit in the aged brain

Effects of age and military service on memory and cognitive flexibility in a virtual Morris water maze task

The Role of Nrf2 in Brain Cellular Senescence

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