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Filtering by: Subject Protein folding Language English [eng]

Mass spectrometric analysis of proteins and peptides : elucidation of the folding pathways of recombinant human macrophage colony stimulating factor beta

Creator:

Zhang, Yuan Heidi

Abstract:

Recombinant human macrophage colony stimulating factor beta (rhm-CSFβ) is a glycoprotein that stimulates the proliferation, differentiation and survival of cells belonging to the monocyte-macrophage lineage. It contains nine inter-subunit and intra-subunit disulfide bonds and represents an excellent model system for studying disulfide bond formation during protein folding because the assembly...

Resource Type:

Dissertation

Full Text:

bond formation during protein folding in general. rhm-CSF8 was modified by partial reduction of
Analysis of secondary structures in nucleic acid binding proteins and nuclear magnetic resonance investigation of helix propagation and residual motions in proteins

Creator:

Hicks, Joshua M.

Abstract:

This thesis involves analyses of 3₂-helices, a-helices and of the change in residual entropy of a protein upon chemical modification. Part of the long-term goal of understanding the formation, function and stability of proteins requires that all conformations be accurately assigned and structurally understood. By a statistical analysis of 258...

Resource Type:

Dissertation

Full Text:

structural alignment of the YHGH peptide. TABLE OF CONTENTS 1. Introduction . 1 1.1 Protein Folding . 1