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Creator:: Medlock, Jan, Atkins, Katherine E., Thomas, David N., Aksoy, Serap, and Galvani, Alison P.
Abstract:: Genetic-modification strategies are currently being developed to reduce the transmission of vector-borne diseases, including African trypanosomiasis. For tsetse, the vector of African trypanosomiasis, a paratransgenic strategy is being considered: this approach involves modification of the commensal symbiotic bacteria Sodalis to express trypanosome-resistance-conferring products. Modified Sodalis can then be driven into...
Resource Type:: Article
Full Text:: , Serap Aksoy2, Alison P. Galvani2 1 Department of Biological Sciences, Oregon State University

Creator:: Michalkova, Veronika, Benoit, Joshua B., Attardo, Geoffrey M., Medlock, Jan, and Aksoy, Serap
Abstract:: Impact of reproductive processes upon female health has yielded conflicting results; particularly in relation to the role of reproduction-associated stress. We used the viviparous tsetse fly to determine if lactation, birth and involution lead to damage from oxidative stress (OS) that impairs subsequent reproductive cycles. Tsetse females carry an intrauterine...
Resource Type:: Article

Creator:: Gilbert, Jennifer A., Medlock, Jan, Townsend, Jeffrey P., Aksoy, Serap, Mbah, Martial Ndeffo, and Galvani, Alison P.
Abstract:: Human African trypanosomiasis (HAT), transmitted by tsetse flies, has historically infected hundreds of thousands of individuals annually in sub-Saharan Africa. Over the last decade, concerted control efforts have reduced reported cases to below 10,000 annually, bringing complete elimination within reach. A potential technology to eliminate HAT involves rendering the flies...
Resource Type:: Article

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