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Synthesis and oligomerization of Delta, 4-diamino-2-oxo-1(2H)-pyrimidinehexanoic acid

Creator:: Huang, Sung-ben
Resource Type:: Dissertation
Full Text:: blocks for the construction of an uncharged stereoregular oligonucleotide analogue. The key intermediate

Advances in solid phase synthesis of neutral oligonucleotide analogues

Creator:: Wang, Haiyan, 1963-
Abstract:: A novel acyl protecting group for cytosine and adenine has been prepared from 4-( chloromethyl) benzoic acid. Reaction of the acid with morpholine produces 4-( 4-morpholinyl )methyl benzoic acid which is converted to it's acid chloride with thionyl chloride. This may be used to acylate cytidine and adenosine under standard...
Resource Type:: Masters Thesis
Full Text:: oligonucleotide analogues AN ABSTRACT OF THE THESIS OF Haiyan Wang for the degree of Master of Science in

Solid-phase synthesis and biophysical testing of uncharged acyclic oligonucleotide analogues

Creator:: Nelson, Jeffrey Stephen, 1962-
Resource Type:: Dissertation
Full Text:: and Biophysical Testing of Uncharged Acyclic Oligonucleotide Analogues. Abstract approved: Dwight D

Design of B-form specific DNA binding oligonucleotide analogues : investigations of novel recognition moieties for triple helix formation

Creator:: Hogeland, Jane S.
Resource Type:: Dissertation
Full Text:: Design of B-form specific DNA binding oligonucleotide

Characterization of a cDNA encoding a procine adipocyte membrane protein

Creator:: Vergin, Kevin L.
Abstract:: In recent years, the general public has recognized the dangers of a high fat diet and are demanding meat with lower fat content. This demand has stimulated research in the growth and regulation of adipocytes. However, despite much effort, no adipocyte-specific plasma membrane markers from any species are available as...
Resource Type:: Masters Thesis
Full Text:: to reduce to monomeric units. Oligonucleotide primers were designed to amplify a genomic fragment by

Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice

Creator:: Cao, Limin, Han, Gang, Lin, Caorui, Gu, Ben, Gao, Xianjun, Moulton, Hong M., Seow, Yiqi, and Yin, HaiFang
Abstract:: Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
Resource Type:: Article

Evaluation of peptide phosphorodiamidate morpholino oligomers as a novel antibiotic therapy

Creator:: Kaller, Margo
Abstract:: Peptide-phosphorodiamidate morpholino oligomers (PPMOs) are synthetic DNA mimics that bind and silence gene targets. Through designing PPMOs that silence essential or resistance genes in pathogens, these antisense oligomers could be utilized as novel antimicrobials. Towards this end, my thesis employed minimum inhibitory concentration assays (MICs) to identify PPMOs capable of...
Resource Type:: Masters Thesis
Full Text:: ability. As artificial mimics of DNA molecules, compounds in the antisense oligonucleotide family are

Involvement of the Ets-1 transcription factor in early bovine and porcine embryo development

Creator:: Stauber, Leah
Abstract:: Early embryo development is dependent on maternally derived RNA and protein synthesized during oogenesis. In the bovine embryo this dependence lasts until the 8-16 cell stage, at which time embryonic transcripts become essential for continued development. One proposed mechanism for this transition from maternal to zygotic control of development (maternal...
Resource Type:: Dissertation
Full Text:: vivo-derived embryos. Blocking Ets-1 expression with antisense oligonucleotides inhibited

Expression of the Ets family of transcription factors in early bovine and ovine embryo development

Creator:: Collins, Jonna Erin
Abstract:: Maternally-derived transcripts and proteins support early bovine and ovine embryo development until the 8- to 16-cell stage, at which time embryonic transcripts become essential for continued development. One purported mechanism for the switch from maternal to zygotic control of development (maternal to zygotic genome activation; MZGA) is the appearance of...
Resource Type:: Masters Thesis
Full Text:: superovulated cows and cultured in 1, 2.5, 5, or 1 OjiM concentrations of sense or antisense Ets- 1

Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency

Creator:: Yin, HaiFang, Boisguerin, Prisca, Moulton, Hong M., Betts, Corinne, Seow, Yiqi, Boutilier, Jordan, Wang, Qingsong, Walsh, Anthony, Lebleu, Bernard, and Wood, Matthew J. A.
Abstract:: We have recently reported that cell-penetrating peptides (CPPs) and novel chimeric peptides containing CPP (referred as B peptide) and muscle-targeting peptide (referred as MSP) motifs significantly improve the systemic exon-skipping activity of morpholino phosphorodiamidate oligomers (PMOs) in dystrophin-deficient mdx mice. In the present study, the general mechanistic significance of the...
Resource Type:: Article

ScholarsArchive@OSU

Synthesis and oligomerization of Delta, 4-diamino-2-oxo-1(2H)-pyrimidinehexanoic acid

Advances in solid phase synthesis of neutral oligonucleotide analogues

Solid-phase synthesis and biophysical testing of uncharged acyclic oligonucleotide analogues

Design of B-form specific DNA binding oligonucleotide analogues : investigations of novel recognition moieties for triple helix formation

Characterization of a cDNA encoding a procine adipocyte membrane protein

Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice

Evaluation of peptide phosphorodiamidate morpholino oligomers as a novel antibiotic therapy

Involvement of the Ets-1 transcription factor in early bovine and porcine embryo development

Expression of the Ets family of transcription factors in early bovine and ovine embryo development

Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency

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