Index Catalog // ScholarsArchive@OSU

Full membrane spanning self-assembled monolayers as model systems for UHV-based studies of cell-penetrating peptides

Creator:: Franz, Johannes, Graham, Daniel J., Schmüser, Lars, Baio, Joe E., Lelle, Marco, Peneva, Kalina, Müllen, Klaus, Castner, David G., Bonn, Mischa, and Weidnera, Tobias
Abstract:: Biophysical studies of the interaction of peptides with model membranes provide a simple yet effective approach to understand the transport of peptides and peptide based drug carriers across the cell membrane. Herein, the authors discuss the use of self-assembled monolayers fabricated from the full membrane-spanning thiol (FMST) 3-((14-((40-((5-methyl-1-phenyl-35-(phytanyl)oxy- 6,9,12,15,18,21,24,27,30,33,37-undecaoxa-2,3-dithiahenpentacontan-51-yl)oxy)-[1,10-biphenyl]-4- yl)oxy)tetradecyl)oxy)-2-(phytanyl)oxy...
Resource Type:: Article
Full Text:: -assembled monolayers as model systems for UHV-based studies of cell-penetrating peptides. Biointerphases

Probing the orientation of electrostatically immobilized cytochrome C by time of flight secondary ion mass spectrometry and sum frequency generation spectroscopy

Creator:: Baio, Joe E., Weidner, Tobias, Ramey, Dennis, Pruzinsky, Leah, and Castner, David G.
Abstract:: By taking advantage of the electron pathway through the heme group in cytochrome c (CytoC) electrochemists have built sensors based upon CytoC immobilized onto metal electrodes. Previous studies have shown that the electron transfer rate through the protein is a function of the position of this heme group with respect...
Resource Type:: Article
Full Text:: 2084927726102116 1..8 Baio et al. Biointerphases 2013, 8:18 http

High aspect ratio nanoimprinted grooves of poly(lactic-co-glycolic acid) control the length and direction of retraction fibers during fibroblast cell division

Creator:: Su, Yi-Hsuan, Chiang, Po-Chieh, Cheng, Li-Jing, Lee, Chau-Hwang, Swami, Nathan S., and Chou, Chia-Fu
Abstract:: Retraction fibers (RFs) determine orientation of the cell division axis and guide the spreading of daughter cells. Long and unidirectional RFs, which are especially apparent during mitosis of cells in three-dimensional (3D) environments, enable improved control over cell fate, following division. However, 3D gel environments lack the cues necessary for...
Resource Type:: Article
Full Text:: fibroblast cell division. Biointerphases, 10(4), 041008. doi:10.1116/1.4936589 10.1116/1.4936589 Springer

Differential surface activation of the A1 domain of von Willebrand factor

Creator:: Tronic, Elaine H., Yakovenko, Olga, Weidner, Tobias, Baio, Joe E., Penkala, Rebecca, Castner, David G., and Thomas, Wendy E.
Abstract:: The clotting protein von Willebrand factor (VWF) binds to platelet receptor glycoprotein Ibα (GPIbα) when VWF is activated by chemicals, high shear stress, or immobilization onto surfaces. Activation of VWF by surface immobilization is an important problem in the failure of cardiovascular implants, but is poorly understood. Here, the authors...
Resource Type:: Article
Full Text:: ; wendyt@uw.edu 029803-1 Biointerphases 11(2), June 2016 1934-8630/2016/11(2)/029803/9 VC Author(s) 2016

Probing Structure, Selectivity, and Orientation of Biomolecules to Cell Membranes by Sum Frequency Generation

Creator:: Golbek, Thaddeus W.
Abstract:: Cell membranes act as barriers against unwanted movement of ions and biomolecules and are complex surfaces littered with protein channels, ion channels, cholesterol, and a myriad of different proteins. While this surface is extremely well studied, there is still much we do not know. The work in this dissertation demonstrates...
Resource Type:: Dissertation
Full Text:: Biointerphases 2017, 12 (2), 02D406. 1.2.2 Objective 2 Combine SFG and theoretically determined SFG spectra

Probing the Biophysical interactions of Anti-Microbial Peptide WLBU2 Using Model Membrane Systems

Creator:: Golbek, Thaddeus W.
Abstract:: WLBU2 is an engineered cationic amphiphilic peptide that targets Gram-positive and Gram-negative bacteria, and envelopes endotoxin while avoiding other cell types. The exact mechanism of how WLBU2 targets, binds, and disrupts bacterial cell membranes is still not completely known. Thus, the overall goal of this investigation is to determine the...
Resource Type:: Masters Thesis

Spherical Au Nanoparticle Interaction with Lipid Monolayers Probed with Sum Frequency Generation Spectroscopy

Creator:: Faase, Ryan A.
Abstract:: Nanoparticles have become more prevalent from their use in sunscreen to antimicrobial agents in socks. In light of these applications, gaining a fundamental understanding of how NPs interact with humans is crucial for their future. Specifically, how cells interact with NPs and what factors drive the modes of cellular uptake....
Resource Type:: Masters Thesis

Towards a Selectively Bioactive Surface for the Removal of Circulating Endotoxin in Blood

Creator:: Raman, Ramya
Abstract:: Sepsis is an inflammatory reaction occurring throughout the human body to infections caused by bacteria, fungi, and or other forms of pathogens. It is essential to find an alternative treatment method for sepsis, to lessen the dependence on antibiotics. Hemoperfusion is an absorbent device that removes select targets from blood,...
Resource Type:: Dissertation
Full Text:: work in chapter 1, in press: Biointerphases 2017. Objective 2: Create a modified bacteriophage

Multi-Technique Characterizations of Natural and Biomimetic Adhesives

Creator:: Fowler, James E.
Abstract:: There have been many attempts to characterize and mimic natural fluid-based adhesive systems. However, very few of these studies have examined surface or interfacial interactions between adhesive and substrate. Furthermore, until now no study has used a combination of surface analytical and kinematic techniques to determine the precise chemical mechanisms...
Resource Type:: Dissertation

Assessing Changes in Biological Interactions of Lipid-Coated Gold and Silver Nanoparticles Based on Physicochemical Properties

Creator:: Engstrom, Arek Mackenzie
Abstract:: Nanoparticles (NPs), particles defined by their size in a single dimension (1-100 nm), are being increasingly incorporated into commercial and industrial products due to their high surface area to volume ratio that gives them unique properties, such as optical tunability and higher reactivity than their bulk counterparts. NPs can be...
Resource Type:: Masters Thesis

ScholarsArchive@OSU

Full membrane spanning self-assembled monolayers as model systems for UHV-based studies of cell-penetrating peptides

Probing the orientation of electrostatically immobilized cytochrome C by time of flight secondary ion mass spectrometry and sum frequency generation spectroscopy

High aspect ratio nanoimprinted grooves of poly(lactic-co-glycolic acid) control the length and direction of retraction fibers during fibroblast cell division

Differential surface activation of the A1 domain of von Willebrand factor

Probing Structure, Selectivity, and Orientation of Biomolecules to Cell Membranes by Sum Frequency Generation

Probing the Biophysical interactions of Anti-Microbial Peptide WLBU2 Using Model Membrane Systems

Spherical Au Nanoparticle Interaction with Lipid Monolayers Probed with Sum Frequency Generation Spectroscopy

Towards a Selectively Bioactive Surface for the Removal of Circulating Endotoxin in Blood

Multi-Technique Characterizations of Natural and Biomimetic Adhesives

Assessing Changes in Biological Interactions of Lipid-Coated Gold and Silver Nanoparticles Based on Physicochemical Properties

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