Index Catalog // ScholarsArchive@OSU

Creator:: Pandey, Abhishek, Mubayi, Anuj, and Medlock, Jan
Abstract:: Various simple mathematical models have been used to investigate dengue transmission. Some of these models explicitly model the mosquito population, while others model the mosquitoes implicitly in the transmission term. We study the impact of modeling assumptions on the dynamics of dengue in Thailand by fitting dengue hemorrhagic fever (DHF)...
Resource Type:: Article
Full Text:: vector–host and SIR models for dengue transmission Abhishek Pandey∗ Anuj Mubayi† Jan Medlock

Creator:: Medlock, Jan, Pandey, Abhishek, Parpia, Alyssa S., Tang, Amber, Skrip, Laura A., and Galvani, Alison P.
Abstract:: The HIV pandemic continues to impose enormous morbidity, mortality and economic burdens across the globe. Simultaneously, innovations in antiretroviral therapy, diagnostic approaches and vaccine development are providing novel tools for treatment-as-prevention and prophylaxis. We developed a mathematical model to evaluate the added benefit of an HIV vaccine in the context...
Resource Type:: Dataset

Creator:: Medlock, Jan, Pandey, Abhishek, Parpia, Alyssa S., Tang, Amber, Skrip, Laura A., and Galvani, Alison P.
Abstract:: The HIV pandemic continues to impose enormous morbidity, mortality and economic burdens across the globe. Simultaneously, innovations in antiretroviral therapy, diagnostic approaches and vaccine development are providing novel tools for treatment-as-prevention and prophylaxis. We developed a mathematical model to evaluate the added benefit of an HIV vaccine in the context...
Resource Type:: Article

Creator:: Gilbert, Jennifer A., Medlock, Jan, Townsend, Jeffrey P., Aksoy, Serap, Mbah, Martial Ndeffo, and Galvani, Alison P.
Abstract:: Human African trypanosomiasis (HAT), transmitted by tsetse flies, has historically infected hundreds of thousands of individuals annually in sub-Saharan Africa. Over the last decade, concerted control efforts have reduced reported cases to below 10,000 annually, bringing complete elimination within reach. A potential technology to eliminate HAT involves rendering the flies...
Resource Type:: Article

Creator:: Michalkova, Veronika, Benoit, Joshua B., Attardo, Geoffrey M., Medlock, Jan, and Aksoy, Serap
Abstract:: Impact of reproductive processes upon female health has yielded conflicting results; particularly in relation to the role of reproduction-associated stress. We used the viviparous tsetse fly to determine if lactation, birth and involution lead to damage from oxidative stress (OS) that impairs subsequent reproductive cycles. Tsetse females carry an intrauterine...
Resource Type:: Article

Creator:: Medlock, Jan, Atkins, Katherine E., Thomas, David N., Aksoy, Serap, and Galvani, Alison P.
Abstract:: Genetic-modification strategies are currently being developed to reduce the transmission of vector-borne diseases, including African trypanosomiasis. For tsetse, the vector of African trypanosomiasis, a paratransgenic strategy is being considered: this approach involves modification of the commensal symbiotic bacteria Sodalis to express trypanosome-resistance-conferring products. Modified Sodalis can then be driven into...
Resource Type:: Article
Full Text:: Control Strategy for African Trypanosomiasis Jan Medlock1,2*, Katherine E. Atkins2, David N. Thomas2

Creator:: Ndeffo Mbah, Martial L., Medlock, Jan, Meyers, Lauren Ancel, Galvani, Alison P., and Townsend, Jeffrey P.
Abstract:: Identification of the optimal vaccine allocation for the control of influenza requires consideration of uncertainty arising from numerous unpredictable factors, including viral evolution and diversity within the human population’s immunity as well as variation in vaccine efficacy. The best policy must account for diverse potential outcomes based on these uncertainties....
Resource Type:: Article

Creator:: Molaei, Goudarz, Thomas, Michael C., Muller, Tim, Medlock, Jan, Shepard, John J., Armstrong, Philip M., and Andreadis, Theodore G.
Abstract:: Background: Eastern equine encephalitis (EEE) virus (Togaviridae, Alphavirus) is a highly pathogenic mosquito-borne zoonosis that is responsible for occasional outbreaks of severe disease in humans and equines, resulting in high mortality and neurological impairment in most survivors. In the past, human disease outbreaks in the northeastern U.S. have occurred intermittently...
Resource Type:: Article

Creator:: Scully, Clare M., Lee, Rebecca L, Pielstick, Leon, Medlock, Jan, Patton, Kristin M., Collins, Gail H., and Kutzler, Michelle A.
Abstract:: Free-roaming horse (Equus caballus) management is a complex issue incorporating social, economic, emotional, political, and environmental factors. Currently, few proven field techniques exist for managing free-roaming horse population growth, which can reach 20–25% annually. Although there are several strategies available for sterilizing mares when managing free-roaming horse populations, surgical vasectomy...
Resource Type:: Article
Full Text:: ) Clare M. Scully, M.A., M.S., D.V.M., Rebecca L. Lee, Leon Pielstick, D.V.M., Jan Medlock, Ph.D

Creator:: Bracha, Shay, McNamara, Michael, Hilgart, Ian, Milovancev, Milan, Medlock, Jan, Goodall, Cheri, Wickramasekara, Samanthi, and Maier, Claudia S.
Abstract:: Transitional cell carcinoma (TCC), the most common cancer of the urinary bladder in dogs, is usually diagnosed at an advanced disease stage with limited response to chemotherapy. Commercial screening tests lack specificity and current diagnostic procedures are invasive. A proof of concept pilot project for analyzing the canine urinary proteome...
Resource Type:: Article

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