Index Catalog // ScholarsArchive@OSU

Otoferlin Deficiency In Zebrafish Results In Defects In Balance And Hearing: Rescue Of The Balance And Hearing Phenotype With Full-length And Truncated Forms Of Mouse Otoferlin

Creator:: Chatterjee, Paroma, Padmanarayana, Murugesh, Abdullah, Nazish, Holman, Chelsea L., LaDu, Jane, Tanguay, Robert L., and Johnson, Colin P.
Abstract:: Sensory hair cells convert mechanical motion into chemical signals. Otoferlin, a six-C2 domain transmembrane protein linked to deafness in humans, is hypothesized to play a role in exocytosis at hair cell ribbon synapses. To date however, otoferlin has been studied almost exclusively in mouse models, and no rescue experiments have...
Resource Type:: Article

De novo synthesis of a sunscreen compound in vertebrates

Creator:: Osborn, Andrew R., Almabruk, Khaled H., Holzwarth, Garrett, Asamizu, Shumpei, LaDu, Jane, Kean, Kelsey M., Karplus, P. Andrew, Tanguay, Robert L., Bakalinsky, Alan T., and Mahmud, Taifo
Abstract:: Ultraviolet-protective compounds, such as mycosporine-like amino acids (MAAs) and related gadusols produced by some bacteria, fungi, algae, and marine invertebrates, are critical for the survival of reef-building corals and other marine organisms exposed to high-solar irradiance. These compounds have also been found in marine fish, where their accumulation is thought...
Resource Type:: Article
Full Text:: ., Almabruk, K. H., Holzwarth, G., Asamizu, S., LaDu, J., Kean, K. M., ... & Mahmud, T. (2015). De novo

Investigating the impact of chronic atrazine exposure on sexual development in zebrafish

Creator:: Corvi, Margaret M., Stanley, Kerri A., Peterson, Tracy S., Kent, Michael L., Feist, Stephen W., La Du, Jane K., Volz, David C., Hosmer, Alan J., and Tanguay, Robert L.
Abstract:: Atrazine (ATZ) is a selective triazine herbicide used primarily for pre-emergent weed control in corn, sorghum and sugar cane production. It is one of the most widely used herbicides in North America. Some research published over the last decade suggests that chronic exposure to environmentally relevant ATZ concentrations can adversely...
Resource Type:: Article
Full Text:: , Tracy S Peterson c,d , Michael L Kent c,d , Stephen W Feist e , Jane K La Du a,d , David C Volz f

Identification of potential new biomarkers of oxygenated polycyclic aromatic hydrocarbon (OPAH) exposures in zebrafish.

Creator:: Swanson, Annika J.
Abstract:: Oxygenated polycyclic aromatic hydrocarbons (OPAHs) are a class of environmentally prevalent compounds with little known information on their effect in vivo. In a recent study conducted using zebrafish as a model, 38 OPAHs were screened for toxicity. This investigation focuses on two of these OPAHs, 7,12-B[a]AQ and BEZO. Both 7,12-B[a]AQ...
Resource Type:: Honors College Thesis
Full Text:: thank Jane LaDu for her time spent training me, answering questions, and especially with her

Establishing Larval Zebrafish as an In Vivo Model Organism for Characterizing the Roles of Otoferlin, a Sensory Hair Cell Protein Essential for Hearing

Creator:: Chatterjee, Paroma
Abstract:: Auditory defects and disorders are prevalent at all ages and affect 8% of the population in developed nations including newborns and children. Congenital hearing loss is the most common birth defect and it is estimated that 1 in 1000 children are affected by deafness at birth or before the onset...
Resource Type:: Dissertation
Full Text:: acknowledgement section will be incomplete if I do not thank Jane LaDu and Carrie Barton, Faculty Research

Unraveling tissue regeneration using chemical genetics

Creator:: Mathew, Lijoy K.
Abstract:: The emerging field of regenerative medicine is mainly approached by two different aspects. First is the use of stem cell based models to generate a suite of differentiated cells for therapeutic applications and the alternative approach is to utilize the non-mammalian models that have the inherent capacity to regenerate their...
Resource Type:: Dissertation
Full Text:: studies and who also had the patience for teaching me various laboratory techniques. Jane LaDu has to be

Evolutionary and Biochemical Studies of C₇-cyclitol Synthases and their Sunscreen Gene Clusters

Creator:: Osborn, Andrew
Abstract:: Sugar phosphate cyclases (SPCs) are enzymes involved in the biosynthesis of many important natural products. SPCs form a unique cyclitol during the early steps in the biosynthesis of many natural products. These natural products include rifamycin, which is chemically modified to rifampicin and used clinically as an antituberculosis drug, and...
Resource Type:: Dissertation
Full Text:: EEVS. Dr. Kelsey Kean modeled the EEVS active site. Jane LaDu assisted with the acquisition and

Vitamin E and the alpha-tocopherol transfer protein during zebrafish embryogenesis

Creator:: Miller, Galen W.
Abstract:: Vitamin E was first described in 1922 as an unknown factor required for impregnated rats to carry their offspring to term. In fact, when vitamin E was chemically characterized it was given the name "tocopherol" derived from the Greek: tokos = childbirth; phero = to bear; and –ol, indicating an...
Resource Type:: Dissertation
Full Text:: the lab, and ultimately became a close friend. I would like to thank Jane Ladu for all of her help

Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

Creator:: Knecht, Andrea L.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) and oxygen-substituted PAHs (OPAHs) are environmental contaminants present in urban air, dust, soil and water resulting from incomplete combustion of organic materials or fossil fuels; found in crude oil and coal; and formed through photoxidation or biotransformation of microbial. It is widely recognized that PAHs pose...
Resource Type:: Dissertation
Full Text:: , Derik Haggard, Mitra Geier, Jane LaDu, Britton Goodale, Lisa Truong, Mike Simonich, Galen Miller, Siba

Expanding Diagnostic Assays for Pseudoloma neurophilia & Description of the Progression of Infection in Adult Zebrafish Populations

Creator:: Schuster, Corbin J.
Abstract:: Pseudoloma neurophilia is the most common pathogen reported in zebrafish (Danio rerio) research facilities and is an important threat to the zebrafish model. This microsporidian parasite can cause clinical disease, but more importantly is a causative agent of non-protocol induced variation in research. Studies utilizing infected zebrafish, could potentially confound...
Resource Type:: Dissertation

ScholarsArchive@OSU

Otoferlin Deficiency In Zebrafish Results In Defects In Balance And Hearing: Rescue Of The Balance And Hearing Phenotype With Full-length And Truncated Forms Of Mouse Otoferlin

De novo synthesis of a sunscreen compound in vertebrates

Investigating the impact of chronic atrazine exposure on sexual development in zebrafish

Identification of potential new biomarkers of oxygenated polycyclic aromatic hydrocarbon (OPAH) exposures in zebrafish.

Establishing Larval Zebrafish as an In Vivo Model Organism for Characterizing the Roles of Otoferlin, a Sensory Hair Cell Protein Essential for Hearing

Unraveling tissue regeneration using chemical genetics

Evolutionary and Biochemical Studies of C₇-cyclitol Synthases and their Sunscreen Gene Clusters

Vitamin E and the alpha-tocopherol transfer protein during zebrafish embryogenesis

Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

Expanding Diagnostic Assays for Pseudoloma neurophilia & Description of the Progression of Infection in Adult Zebrafish Populations

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