Index Catalog // ScholarsArchive@OSU

Alteration of cholesterol disposition by chlordecone is not explained by induction of cyp7a or cyp4a1

Creator:: Lee, JungA
Abstract:: Liver X receptor (LXR), farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor (PPAR) are adopted orphan nuclear receptors that function as lipid sensors. These receptors respond to cellular lipid levels and regulate the expression of target gene. Previously, it was demonstrated that low doses of chlordecone (CD) pretreatment disturbed exogenous...
Resource Type:: Masters Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF JungA Lee for the degree of Master

Chlordecone (CD), a mixed steroid X receptor (SXR) and estrogen receptor alpha(ERα) agonist, altered hepatic cholesterol (CH) homeostasis and lipoprotein metabolism

Creator:: Lee, Junga
Abstract:: Overtly non-toxic doses of organochlorine (OC) insecticides perturb lipid homeostasis in mice and rats. To increase understanding of how chlordecone (CD), an OC insecticide, modulates cholesterol (CH) homeostasis, we determined the effect of CD pretreatment on the tissue and hepatic subcellular distribution of exogenous [¹⁴C]CH. Corn oil alone or CD...
Resource Type:: Dissertation
Full Text:: DISSERTATION OF Junga Lee for the degree of Doctor of Philosophy in Toxicology presented on March 22

Chlordecone Increased Subcellular Distribution of Scavenger Receptor Class B Type II to Murine Hepatic Microsomes without Altering Cytosolic Cholesterol Binding Proteins

Creator:: Scheri, Richard C., Lee, Junga, Barofsky, Douglas F., and Curtis, Lawrence R.
Abstract:: Pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine (OC) pesticide, chlordecone (CD), stimulated biliary excretion of exogenous CH up to 3-fold. Increased biliary excretion occurred without changes in hepatic ATP-binding cassette transporter G8 (ABCG8) of the bile canaliculus or scavenger receptor class B type I (SR-BI)...
Resource Type:: Article
Full Text:: , Junga Lee1, Douglas F. Barofsky2 and Lawrence R. Curtis+ 1Department of

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Creator:: Scheri, Richard C.
Abstract:: Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of...
Resource Type:: Dissertation
Full Text:: . CONTRIBUTION OF AUTHORS Dr. Junga Lee assisted with sample collection and sample preparation for the

Performance of wood treated with prospective organic surface protectants upon outdoor exposure: FTIR spectroscopic analysis of weathered surfaces

Creator:: Schauwecker, Christoph F., McDonald, Armando G., and Morrell, Jeff J.
Abstract:: Visual appeal of wood is as important as its structural integrity in outdoor applications. Discoloration and checking of wood favor the utilization of alternative materials for outdoor cladding and decking. Lignin depolymerization is one of the critical processes leading to weathering. In the present paper, the potential of different classes...
Resource Type:: Article
Full Text:: Kaufmann (2009) , Robinson and Laks (2010) , Pilg å rd et al. (2010) , Lee and Cooper (2010

Antioxidant enzyme response in rainbow trout (Oncorhynchus mykiss) after subchronic exposure to an environmentally-relevant polycyclic aromatic hydrocarbon mixture

Creator:: Norby, Tyler S.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are significant pollutants in aquatic environments. Many are carcinogenic and lead to DNA fragmentation and adduct formation in marine and freshwater organisms. Previous research demonstrates that rainbow trout (Oncorhynchus mykiss) compensate to long-term PAH dietary exposures and reduce the DNA damage. The aim of this study...
Resource Type:: Masters Thesis
Full Text:: Bravo, Junga Lee and Rick Scheri), who have always put up with the fact that I often had no idea

Hydrogen production via a sulfur-sulfur thermochemical water-splitting cycle

Creator:: AuYeung, Nicholas J.
Abstract:: Thermochemical water splitting cycles have been conceptualized and researched for over half a century, yet to this day none are commercially viable. The heavily studied Sulfur-Iodine cycle has been stalled in the early development stage due to a difficult HI-H₂O separation step and material compatibility issues. In an effort to...
Resource Type:: Dissertation
Full Text:: the reverse of the Bunsen reaction. 23 Lee et al. did an extensive study on the reactant ratios

Antimutagenic potency of wheat grain and berry extracts in vitro and anticarcinogenicity of wheat grain in vivo

Creator:: Yu, Zhen
Abstract:: The antimutagenic potency of wheat grain and berry extracts was studied in vitro against several heterocyclic amines (HCAs) using the Salmonella mutagenicity assay and the anticarcinogencity of wheat grain was studied in vivo using the rat colonic aberrant crypt focus assay. Wheat bran, which binds HCAs in vitro, as well...
Resource Type:: Masters Thesis
Full Text:: . Williams'lab: Dr. Sharon Krueger, Ms. Marilyn Henderson, Ms. Susan Tilton, Mr. Dustin Leibeit, Ms. JungA Lee

Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by dibenzo[a,l]pyrene in the B6 129 mouse model : role of the Aryl Hydrocarbon Receptor

Creator:: Yu, Zhen
Abstract:: Lymphomas and leukemias are the most common cancer in children and young adults and in utero exposure to carcinogens may contribute to the etiology of these cancers. A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), was administered to pregnant mice (15 mg/Kg b.w., gavage) on gestation day 17. Significant mortalities in...
Resource Type:: Dissertation
Full Text:: , Mohaiza Dashwood, Barbara McVicar, Dr. Rong Wang, Dr. David Yu, JungA Lee, Dr. John Mata, Dr. Doolalai

Kinetic and modeling investigations of the anaerobic reductive dechlorination of chlorinated ethylenes using single and binary mixed cultures and silicon-based organic compounds as slow-release substrates

Creator:: Yu, Seungho
Abstract:: This study investigated complete reductive dechlorination of chlorinated aliphatic hydrocarbons (CAHs) over a broad range of concentrations. Tetrabutoxysilane (TBOS), as a slow-release anaerobic substrate, was studied for enhanced reductive dechlorination of tetrachioroethylene (PCE) present as a dense non-aqueous liquid (DNAPL). Four different site-mixed cultures were used in the study: Site-300...
Resource Type:: Dissertation
Full Text:: away during my study, are seeing me and are very as happy as I am. To my wife, JungA Lee, I can never

ScholarsArchive@OSU

Alteration of cholesterol disposition by chlordecone is not explained by induction of cyp7a or cyp4a1

Chlordecone (CD), a mixed steroid X receptor (SXR) and estrogen receptor alpha(ERα) agonist, altered hepatic cholesterol (CH) homeostasis and lipoprotein metabolism

Chlordecone Increased Subcellular Distribution of Scavenger Receptor Class B Type II to Murine Hepatic Microsomes without Altering Cytosolic Cholesterol Binding Proteins

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Performance of wood treated with prospective organic surface protectants upon outdoor exposure: FTIR spectroscopic analysis of weathered surfaces

Antioxidant enzyme response in rainbow trout (Oncorhynchus mykiss) after subchronic exposure to an environmentally-relevant polycyclic aromatic hydrocarbon mixture

Hydrogen production via a sulfur-sulfur thermochemical water-splitting cycle

Antimutagenic potency of wheat grain and berry extracts in vitro and anticarcinogenicity of wheat grain in vivo

Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by dibenzo[a,l]pyrene in the B6 129 mouse model : role of the Aryl Hydrocarbon Receptor

Kinetic and modeling investigations of the anaerobic reductive dechlorination of chlorinated ethylenes using single and binary mixed cultures and silicon-based organic compounds as slow-release substrates

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