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  • Influence of iron concentration on the expression of the ferripyoverdine receptor gene FpvAIIb of Pseudomonas aeruginosa

    Creator:
    Glover, Rochelle and Schuster, Martin
    Abstract:
    Pseudomonas aeruginosa is an environmental bacterium which opportunistically infects humans. Commonly residing in irondepleted environments, P. aeruginosa uses iron-chelating molecules called siderophores to scavenge iron from its environment. The most prevalent siderophore used by P. aeruginosa is known as pyoverdine. After the cell synthesizes and secretes pyoverdine, the molecule binds...
    Resource Type:
    Poster
    Full Text:
    Rochelle Glover, Mentor: Dr. Martin Schuster Department of Microbiology, College of Science, Oregon State

  • Quorum-sensing-controlled public goods in Pseudomonas aeruginosa : regulation and application

    Creator:
    Mellbye, Brett L.
    Abstract:
    Cell-to-cell communication by chemical signals, termed quorum sensing (QS), is a common regulatory scheme in the microbial world. Pseudomonas aeruginosa¸ an opportunistic pathogen of burn wounds and cystic fibrosis lungs, uses QS to control the expression of hundreds of genes, particularly those necessary for population level benefits such as biofilm...
    Resource Type:
    Dissertation
    Full Text:
    : _____________________________________________________________ Martin Schuster Cell-to-cell

  • Social Evolution and Regulatory Architecture of Pseudomonas aeruginosa Quorum Sensing

    Creator:
    Asfahl, Kyle L.
    Abstract:
    Cell-cell communication in bacteria is understood to facilitate the coordination of population-wide cooperative behavior in the form of concerted gene expression. The opportunistic pathogen Pseudomonas aeruginosa uses such a communication mechanism to regulate a large group of genes important to virulence strategies in this bacterium. This general mechanism of communication...
    Resource Type:
    Dissertation
    Full Text:
    Abstract approved: ______________________________________________________ Martin Schuster

  • The Social Interactions of Pseudomonas aeruginosa

    Creator:
    Smith, Parker
    Abstract:
    Pseudomonas aeruginosa is a ubiquitous environmental microbe, opportunistic pathogen, and a highly social organism. P. aeruginosa utilizes a wide array of cooperative behaviors to adapt to the environmental conditions around it. These behaviors include quorum sensing (QS), a form a cell-to-cell signaling that coordinates the expression of secreted products in...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ Martin Schuster Pseudomonas aeruginosa is a ubiquitous environmental microbe

  • Insight into the regulation of quorum sensing antiactivator genes qteE and qslA in Pseudomonas aeruginosa

    Creator:
    Lawless, Finn
    Abstract:
    Ubiquitous pathogen Pseudomonas aeruginosa coordinates population-wide activation of virulence genes through quorum sensing (QS), where individuals transition from solo to social behaviors to benefit the population. QS is complex and mechanisms vary from species to species, but the concept is common to the bacterial world and has implications in various...
    Resource Type:
    Honors College Thesis
    Full Text:
    Martin Schuster, Mentor, representing Microbiology

  • Quorum sensing gene regulation in Pseudomonas aeruginosa

    Creator:
    Gupta, Rashmi
    Abstract:
    Pseudomonas aeruginosa is an opportunistic human pathogen that infects immunocompromised individuals such as those suffering from burns or the genetic disorder cystic fibrosis. This organism utilizes a cell-cell communication mechanism known as quorum sensing (QS) to coordinate virulence gene expression and biofilm formation. It has three interconnected QS systems, namely...
    Resource Type:
    Dissertation
    Full Text:
    : Quorum Sensing Gene Regulation in Pseudomonas aeruginosa. Abstract approved: Martin Schuster

  • Strain construction to test the significance of antiactivation in Pseudomonas quorum sensing

    Creator:
    Goff, Shannon Elise
    Abstract:
    The quorum sensing regulatory pathway has been extensively studied for its impact on the virulence of Pseudomonas aeruginosa, an opportunistic pathogen that causes acute and chronic infections in immunocompromised individuals such as those suffering from the genetic disorder cystic fibrosis. Part of the quorum sensing pathway that has not been...
    Resource Type:
    Honors College Thesis
    Full Text:
    . Abstract approved: Martin Schuster The quorum sensing regulatory pathway has been extensively studied

  • The Fitness Costs and Regulatory Strategies of Cooperative Siderophore Production in Pseudomonas

    Creator:
    Sexton, David
    Abstract:
    Cooperative behaviors in bacteria are increasingly appreciated for their relevance to microbial ecology and utility as model systems for social evolution. One example is the secretion of siderophores, a structurally diverse group of compounds that chelate extracellular iron. Siderophore production is considered cooperative because the benefits can be shared with...
    Resource Type:
    Dissertation
    Full Text:
    Abstract approved: Martin Schuster Cooperative behaviors in bacteria are increasingly

  • Analysis of Mutations Affecting Cooperation in Pseudomonas aeruginosa Populations

    Creator:
    Robinson, Tanner M.
    Abstract:
    In a process called quorum sensing (QS), the bacterial pathogen Pseudomonas aeruginosa uses small diffusible signals to coordinate cooperative behaviors via secreted “public goods”. Under QS-dependent growth conditions, social cheaters arise with mutations in lasR, the gene for the primary QS signal receptor. These cheaters do not produce public goods....
    Resource Type:
    Masters Thesis
    Full Text:
    : ______________________________________________________ Martin Schuster In a process called quorum sensing (QS), the bacterial pathogen Pseudomonas

  • Characterization of Quorum-Sensing Diversity in Environmental Pseudomonas aeruginosa Populations

    Creator:
    Grellmann, Elise Kaylene
    Abstract:
    While the quorum-sensing (QS) diversity of the opportunistic pathogen Pseudomonas aeruginosa has been well established in cystic fibrosis (CF) lung infections and in vitro experiments, little is known about its QS-diversity in natural environments. One significant QS-deficient behavior is social cheating. Social cheaters contain mutations that prevent them from producing...
    Resource Type:
    Honors College Thesis
    Full Text:
    aeruginosa Populations. Abstract approved: Martin Schuster While the quorum-sensing (QS