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Kinetic Mechanism of L-α-Glycerophosphate Oxidase from Mycoplasma pneumoniae

Creator:

Maenpuen, Somchart, Watthaisong, Pratchaya, Supon, Pacharee, Sucharitakul, Jeerus, Parsonage, Derek, Karplus, P. Andrew, Claiborne, Al, and Chaiyen, Pimchai

Abstract:

L-α-glycerophosphate oxidase is an FAD-dependent enzyme that catalyzes the oxidation of L-α-glycerophosphate (Glp) by molecular oxygen to generate dihydroxyacetone phosphate (DHAP) and hydrogen peroxide (H₂O₂). The catalytic properties of the recombinant His₆-GlpO from Mycoplasma pneumoniae (His₆-MpGlpO) were investigated with transient and steady-state kinetics and ligand binding. The results indicate that...

Resource Type:

Article

Full Text:

, Pacharee Supon1, Jeerus Sucharitakul2, 4 Derek Parsonage3, P. Andrew Karplus4, Al Claiborne3and Pimchai