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  • Ascorbylation- the biological relevance of covalently bound ascorbic acid

    Creator:
    Kesinger, Nicholas G.
    Abstract:
    Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'. The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...
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    advisor- Prof. Fred Stevens. TABLE OF CONTENTS

  • Development and broad application of a mass spectrometry based metabolomics platform

    Creator:
    Kirkwood, Jay Steven
    Abstract:
    Metabolomics is a comprehensive analysis of small molecules, or metabolites, in a system. Metabolomics is a hypothesis-generating experiment and offers an unbiased analysis of cell metabolism that can aid in the understanding of fundamental biological processes. Metabolomics is widely and broadly applicable in the biological sciences and has been used...
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    . . Jay Steven Kirkwood, Author ACKNOWLEDGEMENTS First I thank my advisor, Fred Stevens for his

  • Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

    Creator:
    Paraiso, Ines L.
    Abstract:
    Obesity is a complex multifactorial disease resulting from excessive energy intake compared to energy expenditure. The excess energy is mostly stored as fat in enlarged adipocytes, but some lipids may infiltrate other organs such as the liver to form ectopic fat. Adipose tissue and ectopic fat produce and secrete a...
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    reader upon request. Ines Leila Paraiso, Author ACKNOWLEDGEMENTS I thank Fred Stevens

  • Investigating the Mechanisms for the Effects of Nitrate Treatment on Exercise Performance and Energy Metabolism

    Creator:
    Keller, Rosa M.
    Abstract:
    Dietary nitrate (NO3-), consumed primarily from leafy green and root vegetables, lowers blood pressure, improves vascular function and aerobic exercise performance. This performance-enhancing effect of nitrate supplementation is largely attributed to the increased bioavailability of the signaling molecule, nitric oxide (NO). Nitric oxide is a ubiquitous free radical signaling molecule...
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    Dissertation
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    : ____________________________________________________ Jan F. Stevens Dietary nitrate (NO3-), consumed primarily from leafy green and root

  • Mass spectrometry techniques to assess the metabolism and toxicity of pharmaceutical and dietary nitrates

    Creator:
    Axton, Elizabeth R.
    Abstract:
    Nitric oxide (NO) is a signaling molecule that regulates blood pressure and vascular tone. Humans produce NO by endothelial nitric oxide synthase (eNOS), which is impaired in patients with cardiovascular disease leading to increased blood pressure, endothelial dysfunction, and an increased risk of adverse cardiovascular outcomes. Maintaining optimal levels of...
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    Dissertation
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    , Fred Stevens, for his continued support in my development as a scientist. You gave me the

  • A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

    Creator:
    Monette, Jeffrey S.
    Abstract:
    Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
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    like to thank the members of my graduate committee, Drs. Balz Frei, Joseph Beckman, J. Fred Stevens

  • In vivo detoxification of acetic acid in Saccharomyces cerevisiae

    Creator:
    Ding, Jun
    Abstract:
    The studies described in this thesis were motivated by ongoing efforts to develop lignocellulosic biomass as an efficient and practical source of renewable energy. Enormous problems complicate these efforts to reduce reliance on greenhouse gas-generating fossil fuels. Simply obtaining the fermentable sugars available in the cellulose and hemicellulose components of...
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    Freitag, and Dr. Fred Stevens for their advice and help towards the completion of my program. Many

  • Mechanistic Studies and Catalytic Engineering of the Pseudoglycosyltransferase VldE

    Creator:
    Abuelizz, Hatem A.
    Abstract:
    This thesis describes an investigation of the molecular basis of the substrate specificity and catalytic mechanism of a unique pseudoglycosyltransferase (PsGT) enzyme, VldE. PsGTs are a newly discovered group of glycosyltransferase (GT)-like proteins that catalyze the transfer of a pseudosugar to an acceptor molecule via a C-N bond formation. This...
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    work. I also thank my thesis committee members Dr. Mark Zabriskie, Dr. Kerry McPhail, Dr. Fred

  • Vitamin E and K interactions : investigating mechanisms of reduced vitamin K status in response to excess vitamin E

    Creator:
    Farley, Sherry Mae
    Abstract:
    The primary goal of my studies was to elucidate the mechanisms for the well-recognized interaction between two nutrients, vitamins E and K. The outcomes from my studies assess mechanisms for adverse effects of vitamin E and provide novel information on mechanisms for vitamin K homeostasis. These findings will provide information...
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    spectrometry support provided by Alan Taylor, Fred Stevens, and Jay Kirkwood. I would also like to express my

  • Measuring innovativeness in the North American softwood sawmilling industry

    Creator:
    Knowles, Christopher David
    Abstract:
    Innovativeness, or the propensity of a firm to create and/or adopt new products, process and business systems, has been measured using several methods in previous research. Examples of theses methods include current technology, self-evaluation, research and development funding, the number of new products, and intellectual property. In addition to the...
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    the data and writing of all chapters of this dissertation. Dr. Steven Shook was involved with the