Index Catalog // ScholarsArchive@OSU

The Effect of Non-Steroidal Anti-Inflammatory Drugs on Canine Transitional Cell Carcinoma and Its Correlation with Cyclooxygenase-2 Expression

Creator:: Weinman, Marcus Andrew
Abstract:: Canine transitional cell carcinoma (TCC) has been shown to have a substantial inflammatory component. It exhibits genotypic and morphologic elements that resemble its human counterpart. Cyclooxygenases (COX) are key enzymes in the synthesis of proinflammatory molecules, such as prostaglandins. Excess prostaglandin production through cyclooxygenases may promote oncogenesis and progression of...
Resource Type:: Honors College Thesis
Full Text:: requirements for the degree of Honors Baccalaureate of Science in Microbiology (Honors Scholar

An Approach to Increasing Yields of a Sunscreen Compound in Recombinant Yeast

Creator:: Vu, Van Anh
Abstract:: The yeast Saccharomyces cerevisiae, commonly used in winemaking, baking, and brewing, also serves as a host for the production of therapeutically valuable pharmaceuticals. Recently, the Bakalinsky laboratory constructed a recombinant yeast strain expressing two zebrafish (Danio rerio) genes in order to produce a UV-protective “sunscreen” compound called gadusol. An antioxidant...
Resource Type:: Honors College Thesis
Full Text:: partial fulfillment of the requirements for the degree of Honors Baccalaureate of Science in

Interaction of the human Voltage-Dependent Anion Channel 1 protein (VDAC-1) with Mycobacterium avium and its role in bacterial survival within phagocytic cells

Creator:: Pham, Tuan
Abstract:: M. avium is an opportunistic pathogen that primarily infects macrophages. In order to survive within the macrophage, M. avium secretes proteins into the host cell cytoplasm to inhibit specific functions such as phagosome acidification, altering pathways as well as initiating apoptosis. However, little is known about how those secreted proteins...
Resource Type:: Honors College Thesis
Full Text:: Pham for the degree of Honors Baccalaureate of Science in Biochemistry and Biophysics presented on

The broad spectrum antiviral compound ST-669 affects vesicular trafficking in Chlamydia-infected cells

Creator:: Valiant, William G.
Abstract:: Our laboratory is exploring the mechanism of action of a novel broad spectrum antiviral, ST-669. This compound has activity against a variety of different viruses and the obligate intracellular bacterium, Chlamydia. In this study, we explored the effects of ST-669 when the cell cycle of the host cells was altered....
Resource Type:: Honors College Thesis
Full Text:: Baccalaureate of Science Microbiology (Honors Scholar) Presented May 13, 2015 Commencement June

Quantification of Lipoic Acid InducedChanges in Nrf2-Mediated Stress Response

Creator:: Hobbs, Helen T.
Abstract:: As organisms age they lose the ability to respond to both exogenous and endogenous stresses, therefore placing them at a greater risk for the development of many diseases. The transcription factor Nrf2 is responsible for the induction of many oxidative stress response genes and therefore 3proteins. Additionally, Nrf2-mediated stress response...
Resource Type:: Honors College Thesis
Full Text:: degree of Honors Baccalaureate of Science in Biochemistry and Biophysics presented on August 15 th

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Creator:: You, Hyekyoung Hannah
Abstract:: Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...
Resource Type:: Honors College Thesis
Full Text:: Science in BioResource Research, Toxicology and Biotechnology (Honors Scholar) Presented

A genomic and proteomic characterization of the first cultured oligotrophic marine Gammaproteobacterium from the SAR92 clade

Creator:: Mellbye, Brett L.
Abstract:: High-throughput culturing (HTC) consisting of extinction culturing in autoclaved seawater has led to the isolation and characterization of many novel strains of oligotrophic marine bacteria. Strain HTCC 2207 was isolated from the Oregon coast by the HTC method. Phylogenetic analysis based on 16S rRNA gene sequence showed that this strain...
Resource Type:: Honors College Thesis
Full Text:: THESIS OF Brett L. Mellbye for the degree of Honors Baccalaureate of Science in Microbiology presented

Mycobacterium abscessus genetic determinants associated with intrinsic resistance to antibiotics

Creator:: Gorzynski, Mylene
Abstract:: M. abscessus subsp. abscessus is a nontuberculous mycobacterium causing pulmonary infections in immunocompromised patients. The treatment of MAB infections is challenging due to its natural resistance to most antibiotics. To identify MAB genetic factors that are involved in mechanisms of the antibiotic tolerance, we screened the library of 2,000 gene...
Resource Type:: Honors College Thesis
Full Text:: Honors Baccalaureate of Science in Biochemistry and Molecular Biology (Honors Scholar

Bioethanol production from lignocellulosicbiomass: assessing genes linked to acetic acid stress in Saccharomyces cerevisiae

Creator:: Montgomery, Tyler P.
Abstract:: Lignocellulosic biomass represents a vast and renewable source of fermentable sugar for production of biofuels. However, native lignocellulose—comprised of cellulose, hemicellulose and lignin—is refractory to degradation because the crystalline cellulose is not easily hydrolyzed by cellulases. Standard chemical treatments of lignocellulose to reduce the crystallinity of cellulose prior to enzymatic...
Resource Type:: Honors College Thesis
Full Text:: Tyler P. Montgomery for the degree of Honors Baccalaureate of Science in Biology presented on February

ScholarsArchive@OSU

The Effect of Non-Steroidal Anti-Inflammatory Drugs on Canine Transitional Cell Carcinoma and Its Correlation with Cyclooxygenase-2 Expression

An Approach to Increasing Yields of a Sunscreen Compound in Recombinant Yeast

Interaction of the human Voltage-Dependent Anion Channel 1 protein (VDAC-1) with Mycobacterium avium and its role in bacterial survival within phagocytic cells

The broad spectrum antiviral compound ST-669 affects vesicular trafficking in Chlamydia-infected cells

Quantification of Lipoic Acid InducedChanges in Nrf2-Mediated Stress Response

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

A genomic and proteomic characterization of the first cultured oligotrophic marine Gammaproteobacterium from the SAR92 clade

Mycobacterium abscessus genetic determinants associated with intrinsic resistance to antibiotics

Bioethanol production from lignocellulosicbiomass: assessing genes linked to acetic acid stress in Saccharomyces cerevisiae

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