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Development of Micellar and Nanoparticle Structures based on Polyester Diblock Copolymer Platform for the Treatment of Metastatic Tumors

Creator:

Doddapaneni, Bhuvana S.

Abstract:

Poor aqueous solubility of a large number of newly discovered chemical entities is posing a significant challenge for the formulation industry and is delaying their drug development. The number of formulation techniques available to solubilize these poorly soluble molecules is very limited. In addition to that, traditional formulation methods involve...

Resource Type:

Dissertation

Full Text:

Bhuvana S. Doddapaneni for the degree of Doctor of Philosophy in Pharmacy presented on June 9, 2016
Preparation of Tacrolimus-loaded Biodegradable Nanoparticles for Sustained Drug Delivery

Creator:

Kinser, Reid

Abstract:

Tacrolimus is an immunosuppressant drug approved by the FDA for the prevention of organ transplant rejection. However, the use of this drug is hindered by its narrow therapeutic window and extreme insolubility in water. Due to these properties, the currently used tacrolimus preparations must be administered once or twice daily...

Resource Type:

Honors College Thesis

Full Text:

, PhD Special Help Shyam Doddapaneni Adel Al Fatease Funding OSU College of Pharmacy
Development of thermosensitive injectable hydrogel and transdermal controlled release formulations for Tacrolimus

Creator:

Nguyen, Duc X.

Abstract:

TAC is the most commonly used medication in post transplantation maintenance immunosuppression therapy. TAC lipophilicity and its erratic oral absorption especially in the presence of food intake result in great intra- and interpatient pharmacokinetic variations. Complicated dosing and frequent required therapeutic monitoring is thought to be the main cause of...

Resource Type:

Dissertation