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  • Investigating Multimodal Therapies with Nanotechnology to Engineer Advanced Chemoradiation Platforms

    Creator:
    DuRoss, Allison N.
    Abstract:
    The potential for nanomedicine to reduce toxicity and improve therapeutic response to radiation is vast. Clinically, this potential has thus far only begun to be realized with the recent success of the radioenhancing nanoparticle, NBTXR3 by Nanobiotix. Radioenhancing nanoparticles, however, represent only a small class of nanomaterials that may be...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ Conroy Sun Abstract The potential for nanomedicine to reduce toxicity and improve

  • Mechanics Controls Collective Cancer Invasion

    Creator:
    Alobaidi, Amani A.
    Abstract:
    Cancer cell migration in three-dimensional extracellular matrix is a major cause of death for cancer patients. Although extensive studies have elucidated detailed mechanism of single cell 3D invasion and cell-ECM interaction, 3D collective cancer invasion is still poorly understood. 3D collective migration models have unveiled unexpected degrees of diversity and...
    Resource Type:
    Dissertation
    Full Text:
    Chen, Yang Jiao, and Bo sun Physical Biology, Volume 14 4 (2017 ): 045005 Collective cellular

  • Multi-scale Investigation of Bidirectional Feedback Mechanism Between Breast Cancer Cells and Extracellular Matrix

    Creator:
    Kim, Jihan
    Abstract:
    Cell migration is fundamental for physiological processes such as immune re-sponses, wound healing and development. It is also a critical characteristic of metastatic cancer cells. An extensive amount of studies have focused on 2D sub-strates in order to understand the mechanism of cancer metastasis. However, much less is known about...
    Resource Type:
    Dissertation
    Full Text:
    Sun Cell migration is fundamental for physiological processes such as immune re- sponses, wound

  • Mechanics of three-dimensional microenvironments of cells

    Creator:
    Jones, Christopher
    Abstract:
    The structure and mechanics of tissues affect many important cellular functions such as migration, differentiation, and growth. Mechanical interactions between cells and the extracellular matrix (ECM), as well as ECM-mediated mechanical communication between cells, plays a part in coordinating collective cellular dy- namics during critical processes such as morphogenesis, tissue...
    Resource Type:
    Dissertation
    Full Text:
    -Dimensional Microenvironments of Cells Abstract approved: Bo Sun The structure and mechanics of tissues

  • Multicellular monolayer’s self-organization under external stimuli

    Creator:
    Li, Guanyu
    Abstract:
    Cell signaling under external stimulation is a critical mechanism that governs many biological processes such as cell proliferation, cell migration, and cell apoptosis, etc. For multicellular organisms, the ability to synchronize heterogeneous individual cellular responses through intercellular communication is crucial to maintain normal functionality. However, even though the biological pathways...
    Resource Type:
    Dissertation
    Full Text:
    Monolayer’s Self-organization Under External Stimuli Abstract approved: Bo Sun Cell signaling under

  • Morphodynamics of 3D Migrating Cancer Cells

    Creator:
    Eddy, Christopher Z.
    Abstract:
    At the intersection of basic science research and clinical relevance, cancer metastasis and cell invasion is a multifaceted problem that has been investigated for the past several decades. Importantly, cancer cell plasticity, the ability of a single cell to change its phenotype without genetic mutations in response to environmental cues,...
    Resource Type:
    Dissertation
    Full Text:
    of 3D Migrating Cancer Cells Abstract approved: Bo Sun At the intersection of basic science

  • Controlling the Co-Precipitation of Colloidal PbSe Quantum Dots and Their Device Performance in a Diode Architecture

    Creator:
    McCrea, Tyler D.
    Abstract:
    In this work, colloidal PbSe quantum dots (QDs) are shown to be synthesized in a controlled manner by changing the growth time and reaction temperature in a microwave synthesis method. It is explained why quantum dots make such a unique material to create electronic devices and the specific benefits that...
    Resource Type:
    Masters Thesis
    Full Text:
    . I love you forever. Thank you to Prof. Greg Herman and Dr. Haori Yang for allowing me to work on

  • Metabolism of one carbon (C1) and methylated compounds in SAR11 bacteria

    Creator:
    Sun, Jing
    Abstract:
    SAR11 Alphaproteobacteria are the most abundant aerobic chemoheterotrophs in ocean surface waters. Previous studies have indicated SAR11 cells play an important role in marine carbon cycling and consume up to half of some common dissolved organic compounds, such as amino acids. During sequencing of the first SAR11 genome, genes for...
    Resource Type:
    Dissertation
    Full Text:
    THE DISSERTATION OF Jing Sun for the degree of Doctor of Philosophy in Molecular and Cellular

  • A Wide Modulation Range and PVT-Tolerant Spread-Spectrum Modulation Clock Generator

    Creator:
    Sun, Hyuk
    Abstract:
    This dissertation presents a phase domain in-loop-bandwidth spread-spectrum clock generation technique. In this proposed technique, a charge-based discrete-time loop filter is proposed to enable the phase domain in-loop-bandwidth spread-spectrum modulation without a delta-sigma modulator or time-to-digital converter. The in-loop-bandwidth modulation technique maximizes the loop bandwidth to improve phase noise suppression...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Hyuk Sun for the degree of Doctor of Philosophy in Electrical

  • Selective Laser Melting of Duplex Stainless Steel 2205: Microstructure, Mechanical Properties, and Corrosion Performance

    Creator:
    Nigon, Gregory N.
    Abstract:
    The aim of this work was to assess the viability of duplex stainless steel 2205 components built via selective laser melting for seawater applications. First, a comprehensive additive manufacturing assessment was done. The duplex stainless steel 2205 components were selectively laser melted from gas atomized powder (D90 <45m) using a...
    Resource Type:
    Masters Thesis
    Full Text:
    . I thank my committee members, Dr. Megumi Kawasaki and Dr. Bo Sun, for taking the time to attend