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Regulation of phospholipase C-beta isozymes by calmodulin

Creator:

McCullar, Jennifer Star

Abstract:

Phospholipase C-Jβ (PLCβ) is an important effector enzyme in G-protein-coupled signaling pathways. Activation of PLCβ by Gα and Gβy subunits has been fairly well characterized, but little is known about other protein interactions that may also regulate PLCβ function. A yeast two-hybrid screen of a mouse brain cDNA library with...

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Dissertation

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the degree of Doctor of Philosophy in Molecular and Cellular Biology presented on September 22. 2005
In vitro and in vivo approaches for the functional characterization of the scaffold protein, GRASP

Creator:

Venkataraman, Anand

Abstract:

Studies using the pluripotent embryonic carcinoma cell line, P19, as a retinoic acid (RA)-responsive model system have been instrumental towards our understanding of the RA-dependent signaling pathways in development and homeostasis. Grp1-associated scaffold protein (GRASP; also known as Tamalin) was first identified by our group, as a gene robustly induced...

Resource Type:

Dissertation

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Molecular and Cellular Biology presented on November 10, 2009. Title: In vitro and In vivo
Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation

Creator:

Zhang, Yong

Abstract:

Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled signaling pathways. Prior research suggested that some isoforms of PLC-β may exist and function as dimers, but little is known about dimerization of PLC-β. Data from coimmunoprecipitation assays of differentially-tagged PLC-β constructs and sizeexclusion chromatography of native PLC-β support homodimerization...

Resource Type:

Dissertation

Full Text:

DISSERTATION OF Yong Zhang for the degree of Doctor of Philosophy in Molecular and Cellular Biology

ScholarsArchive@OSU

Regulation of phospholipase C-beta isozymes by calmodulin

In vitro and in vivo approaches for the functional characterization of the scaffold protein, GRASP

Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation

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