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Filtering by: Has journal Virus Genes Remove constraint Has journal: Virus Genes License All rights reserved Remove constraint License: All rights reserved Subject Viral genetics Remove constraint Subject: Viral genetics

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  • Targeted development of antivirals against influenza A and respiratory syncytial virus

    Creator:
    Lupfer, Christopher
    Abstract:
    Influenza A and Respiratory Syncytial Virus (RSV) are both enveloped, negative strand RNA viruses which infect the respiratory mucosa of animals and humans. Despite decades of research and development of antivirals and vaccines, both of these viruses continue to be a major health concern throughout the world. The focus of...
    Resource Type:
    Dissertation
    Full Text:
    Development of Antivirals against Influenza A and Respiratory Syncytial Virus. Abstract approved

  • Genomic characterization of a novel leporid Herpes simplex virus

    Creator:
    Babra, Bobby A.
    Abstract:
    The viral family Herpesviridae consists of large double stranded DNA viruses including eight species that infect humans with varying pathology from benign rashes to cancerous cell transformation. From three subfamilies, alpha-, beta- and gammaherpes, the alphaherpes contains the genera iltovirus, mardivirus, varicellovirus and simplex, two of which, the human simplex...
    Resource Type:
    Dissertation
    Full Text:
    core protein coding genes with notable variation in the IE gene, ICP34.5 (a neurovirulent factor), a

  • The conserved biology of herpesvirus latency : a study in cyprinid herpesvirus 3

    Creator:
    Reed, Aimee N.
    Abstract:
    Cyprinid herpesvirus 3 (CyHV-3), commonly known as koi herpesvirus (KHV), is a member of the Alloherpesviridae and is a deadly pathogen for koi and common carp, Cyprinus carpio. It causes severe gill necrosis and nephritis, dermal ulceration and hemorrhage, and mass mortality of up to 100% of affected fish. Fish...
    Resource Type:
    Dissertation
    Full Text:
    of host protein synthesis inhibitors. These genes are typically involved in viral gene

  • Translation of dengue virus RNA : influence of the untranslated regions on 5´-cap dependent translation and ribosome scanning

    Creator:
    Chiu, Wei-Wei
    Abstract:
    In this thesis, I studied the translation of dengue virus RNA using a luciferase reporter gene system in Vero cells. The dengue reporter mRNA construct, which harbors 5´-terminal viral nts and 3´-terminal nts, could be translated efficiently compared to an alpha globin reporter construct. The 5´-cap structure and 3´-untranslated region...
    Resource Type:
    Dissertation
    Full Text:
    thesis, I studied the translation of dengue virus RNA using a luciferase reporter gene system in Vero