Index Catalog // ScholarsArchive@OSU

In vivo assessment of nanomaterial-induced toxicity using embryonic zebrafish

Creator:: Usenko, Crystal Y.
Abstract:: Due to their unique physical, chemical, and magnetic properties, nanomaterials have great potential for industrial development. There is a pressing need to develop rapid whole animal-based testing assays to assess the potential toxicity of engineered nanomaterials. To meet this challenge the embryonic zebrafish model was employed to determine the toxicity...
Resource Type:: Masters Thesis
Full Text:: approved: _____________________________________________________________ Robert L. Tanguay Due to

Embryonic and Larval Zebrafish Bioassays for Biomedical Research : The Larval Photomotor Response Screening Assay and Phenotype

Creator:: Fisher, Joseph A.
Abstract:: Laboratories around the world are using the zebrafish model for biomedical research and conducting investigations using morphological, physiological, behavioral, and genomic endpoints. All assays provide information, but physiological and behavioral endpoints or phenotypes are a fast way to understand how an animal is responding to its environment. We investigate the...
Resource Type:: Dissertation
Full Text:: : E. Andrés Houseman Robert L. Tanguay Laboratories around the world are using the zebrafish model

Developing rapid in vivo assays to investigate structure response relationships

Creator:: Truong, Lisa
Abstract:: Incorporation of nanoparticles (NPs) into consumer products is on the rise and human exposure to NPs is unavoidable. Currently, there is insufficient data to assess the safety of nanoparticles. I conducted a series of five studies using the zebrafish model to determine which NP components (i.e., core material or surface...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________________ Robert L. Tanguay Incorporation of nanoparticles (NPs) into consumer products is on the rise

Developmental neurobehavioral toxicity of bisphenol A in zebrafish (Danio rerio)

Creator:: Saili, Katerine Schletz
Abstract:: Billions of pounds of bisphenol A (BPA) are produced annually around the globe for the manufacture of numerous consumer products, including polycarbonate food and water containers, the protective resin linings of food cans, thermal printing paper, and dental fillings. BPA exposure during nervous system development has been associated with learning...
Resource Type:: Dissertation
Full Text:: approved: _____________________________________________________ Robert L. Tanguay Billions of pounds of

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Creator:: Haggard, Derik
Abstract:: There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________________ Robert L. Tanguay There are more than 87,000 chemicals in current use with little to no

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Creator:: Chlebowski, Anna C.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are among the most widely known and studied environmental contaminants, originating from a range of natural and anthropogenic sources. PAHs are known to occur in the environment as complex mixtures, containing both unsubstituted PAHs, as well as a range of PAH derivatives. Among the less-studied of...
Resource Type:: Dissertation
Full Text:: : _________________________________________________________________ Staci L. Massey Simonich Robert L. Tanguay

Pseudoloma neurophilia in the Zebrafish (Danio rerio) : Consequences of Infection on Neurobehavioral and Biomedical Research using a Burgeoning Model Organism

Creator:: Spagnoli, Sean
Abstract:: Since its inception as a laboratory animal in the early 1970s, the zebrafish has proven itself a rising star in the world of comparative biomedical sciences due to its short generation time, ease of care, external fertilization, and transparent larvae. In a very few decades, the zebrafish has been utilized...
Resource Type:: Dissertation
Full Text:: . I would also like to thank my thesis committee, consisting of Michael L. Kent, Robert Bildfell

Automated manipulation of zebrafish embryos for high-throughput toxicology screening of nanomaterials

Creator:: Mandrell, David
Abstract:: The field of nanotechnology has been rapidly developing new materials. These materials have become incorporated into consumer products and the environment after only minimal assessment of their effects on human health or the environment. The toxicity of these new nanomaterials remains unknown due to the unpredictable nature of the core...
Resource Type:: Masters Thesis
Full Text:: to thank Dr. Robert Tanguay for giving me the opportunity to work on a project that I have truly

Establishing Larval Zebrafish as an In Vivo Model Organism for Characterizing the Roles of Otoferlin, a Sensory Hair Cell Protein Essential for Hearing

Creator:: Chatterjee, Paroma
Abstract:: Auditory defects and disorders are prevalent at all ages and affect 8% of the population in developed nations including newborns and children. Congenital hearing loss is the most common birth defect and it is estimated that 1 in 1000 children are affected by deafness at birth or before the onset...
Resource Type:: Dissertation
Full Text:: research perspectives. I would like to express my sincere gratitude to Prof. Robert L. Tanguay

‘Tis a Gift to be Simple : On Passive Sampling and Compatible Techniques for Reducing the Complexity of Environmental Mixtures

Creator:: Bergmann, Alan J.
Abstract:: Assessing the risk from exposure to a chemical mixture in the environment can seem prohibitively challenging. Most components of the mixture are not readily identifiable, chemicals may interact to cause other-than-additive toxicity, and the number of potential combinations of environmental contaminants is enormous. These challenges can make it seem impossible...
Resource Type:: Dissertation
Full Text:: document. The guidance of each member of my thesis committee, Robert Tanguay, Stacey Harper, Jennifer

ScholarsArchive@OSU

In vivo assessment of nanomaterial-induced toxicity using embryonic zebrafish

Embryonic and Larval Zebrafish Bioassays for Biomedical Research : The Larval Photomotor Response Screening Assay and Phenotype

Developing rapid in vivo assays to investigate structure response relationships

Developmental neurobehavioral toxicity of bisphenol A in zebrafish (Danio rerio)

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Pseudoloma neurophilia in the Zebrafish (Danio rerio) : Consequences of Infection on Neurobehavioral and Biomedical Research using a Burgeoning Model Organism

Automated manipulation of zebrafish embryos for high-throughput toxicology screening of nanomaterials

Establishing Larval Zebrafish as an In Vivo Model Organism for Characterizing the Roles of Otoferlin, a Sensory Hair Cell Protein Essential for Hearing

‘Tis a Gift to be Simple : On Passive Sampling and Compatible Techniques for Reducing the Complexity of Environmental Mixtures

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