In this dissertation, I investigate the evolution and genomes of carabid beetles, a worldwide family of over 38,000 species. I focus on two species-rich groups, the tribes Chlaeniini and Bembidiini, both of which are primarily found on the shores of bodies of water. The former are distinctive for their defensive...
Load flow studies are one of the most essential engineering applications for grid operators because they provide a clear picture of the operating conditions of the power system. Traditionally, the load flow problem is assumed to be deterministic; that is, the system variables contain no randomness. Unfortunately, this assumption is...
Pharmaceuticals, molecular catalysts, and secondary metabolites often contain nitrogen. The problems faced synthesizing compounds which contain nitrogen was because of the Lewis base reactivity of nitrogen lone pairs, and the acidic protons of some nitrogenous functional groups. We developed two methods for the synthesis of nitrogeous compounds. Additionally, we successfully...
In this work we will analyze branching Brownian motion on a finite interval with oneabsorbing and one reflecting boundary, having constant drift rate toward the absorbingboundary. Similar processes have been considered by Kesten ([12]), and more recently byHarris, Hesse, and Kyprianou ([11]). The current offering is motivated largely by the...
Auditory defects and disorders are prevalent at all ages and affect 8% of the population in developed nations including newborns and children. Congenital hearing loss is the most common birth defect and it is estimated that 1 in 1000 children are affected by deafness at birth or before the onset...
The symbiosis between cnidarians, such as corals and sea anemones, and photosynthetic dinoflagellates belonging to the genus Symbiodinium spp. is one of the most productive in the marine environment. This mutualistic endosymbiosis allow reef-building corals to lay down the foundation of coral reef ecosystems, which supports a highly biodiverse community...
Natural products from both terrestrial and marine sources represent a significant source of novel drug leads, and have previously been developed into clinically-approved agents for the treatment of various human diseases. This work represents the biological characterization of the mechanistic basis for activity of several natural product structures in models...
High vegetative growth of Pinot Noir vine is a common problem in most vineyards of Oregon's Willamette Valley, where sunlight exposure and heat accumulation are limited. Consequently, growers in this region commonly use vineyard management strategies to regulate vine vigor and improve grape and wine quality. Wine quality is greatly...
The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...
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Figure 3.3 Biosynthesis of 3-S-L-capreomycidine via non-heme iron α-
ketoglutarate dependent
Coibamide A is a methyl-stabilized cyclic depsipeptide with a lariat side chain that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups program based in Panama. Previous testing of this potent and selective growth-inhibitory agent in the National Cancer Institute (NCI) in vitro 60 human...