Poor aqueous solubility of a large number of newly discovered chemical entities is posing a significant challenge for the formulation industry and is delaying their drug development. The number of formulation techniques available to solubilize these poorly soluble molecules is very limited. In addition to that, traditional formulation methods involve...
Limnology is undergoing a transition to high-throughput -omic analysis of freshwater
bacterial communities. An important first step in making the transition is to
characterize several genomes that can be used as references to guide metagenome
assembly and analysis. Here I characterize four new freshwater cyanobacterial
genomes, a pair of lake...
In the field of construction safety, many researchers have worked to create assessment tools. These tools focus on different aspects of construction safety, such as assessing safety climate, safety culture, etc. Although research indicates that the majority of incidents are caused by unsafe behaviors and acts, there are no comprehensive...
The purpose of this research was to develop and test a radiation detector to perform beta dosimetry and spectroscopy. The detector utilizes plastic scintillator volumes to produce scintillation light in proportion to the amount of energy deposited in them, and a large-area avalanche photodiode to convert the light to electrical...
The focus of this work is on the steady-state analysis of RE circuits using a coupled device and circuit simulator. Efficient coupling algorithms for both the time-domain shooting method and the frequency-domain harmonic balance method have been developed. A modified Newton shooting method considerably improves the efficiency and reliability of...
Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...
Exercise increases B-vitamin (B6, B12, folate) dependent metabolic reactions, especially those related to energy production and the rebuilding and repairing of muscle tissue. These same B-vitamins are also important in maintaining low blood levels of homocysteine (Hcy), a cardiovascular disease (CVD) risk factor. Hcy levels rise when the metabolism of...
The past decade of research has potentiated a revolution in our understanding of mammalian health and evolution by revealing that the gut microbiome plays a central role in mammalian physiology. Our ability to unlock this potential hinges upon the identification of specific groups of gut microbes that elicit effects on...
There has been serious interest in hydrogen as a source of energy in the United States due to its capability of delivering a sustainable, carbon-free energy future. Currently, most hydrogen in the United States is produced via the steam methane reforming of natural gas, which converts methane to hydrogen through...
Photoactivated biomedical tools like fluorescent biosensors and optogenetic proteins have increased in popularity due to the precision targeting and activation used for in vivo applications. In nature, the initially discovered parent proteins exhibit properties such as fluorescence quantum yield (FQY), fluorescence color, and photoswitching dynamics that are unfavorable in mammalian...