Index Catalog // ScholarsArchive@OSU

Acute bioactivation and hepatotoxicity of ketoconazole in rat and the determinant presence of flavin-containing monooxygenase (FMO) isoforms in human duodenum, jejunum, ileum, and colon microsomes and Caco-2 cell line

Creator:: Buckholz, Cheryl J.
Abstract:: Two specific goals were addressed for this dissertation. First to investigate and identify the mechanistic profile of ketoconazole (KT)-induced hepatotoxicity by utilizing in vivo and in vitro approaches determining the mechanism of action for the hepatotoxicity incurred. To date, there has not been a mechanistic determination of the hepatotoxicity associated...
Resource Type:: Dissertation
Full Text:: either phase I or phase II enzymes could have an effect on the efficacy or toxicity of therapeutic drugs

Individual and demographic responses of the gray-tailed Vole (Microtus canicaudus) to an endocrine disruptor

Creator:: Caslin, Tracie M.
Abstract:: In an experimental field study, populations of gray-tailed voles (Microtus canicaudus) were exposed to a commercial formulation of vinclozolin, a fungicide effective for disease control on ornamental plants, turf grasses, and fruits and vegetables. Vinclozolin has been shown in laboratory experiments to behave as an androgen antagonist, impairing the reproductive...
Resource Type:: Masters Thesis
Full Text:: with one application of Curalan® fungicide, Vinclozolin had only a slight effect on the reproductive

Effects of chlorinated aliphatic hydrocarbon degradation on the metabolic enzymes in Nitrosomonas europaea

Creator:: Fawcett, Kimberly A.
Abstract:: The toxic effects of degrading the chlorinated hydrocarbons trichloroethylene (TCE), chloroform (CF) and cis-1,2-dichloroethylene (cis-1,2-DCE) were studied in the bacterium Nitrosomonas europaea. N europaea is an ammonia-oxidizing bacterium that obtains all of its energy from the oxidation of ammonia to nitrite. This metabolic process involves two enzymes, ammonia monooxygenase (AMO)...
Resource Type:: Masters Thesis
Full Text:: polypeptide and in vitro HA() activity 30 2. The effect of light and H202 on N} and N2H4 dependent 02

Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by dibenzo[a,l]pyrene in the B6 129 mouse model : role of the Aryl Hydrocarbon Receptor

Creator:: Yu, Zhen
Abstract:: Lymphomas and leukemias are the most common cancer in children and young adults and in utero exposure to carcinogens may contribute to the etiology of these cancers. A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), was administered to pregnant mice (15 mg/Kg b.w., gavage) on gestation day 17. Significant mortalities in...
Resource Type:: Dissertation
Full Text:: 3-2 Effect of AHR genotype on mortality of offspring born to DBP-treated dams

In Utero Exposure to Arsenic and Mercury : Epigenome-Wide Associations and Newborn Health Outcomes

Creator:: Cardenas, Andres
Abstract:: Mercury and arsenic are known developmental toxicants and environmental exposures are ubiquitous worldwide from natural and anthropogenic sources. Prenatal exposure to both contaminants are independently associated with adverse perinatal health outcomes and latent disease risk that could be in part mediated by epigenetic reprogramming events. Fetal programming events involving DNA...
Resource Type:: Dissertation
Full Text:: methylation in different biological human tissues. Particularly, the effect of arsenic exposure on

Effects of atrazine on olfactory-mediated behaviors in Pacific lamprey (Entosphenus tridentatus)

Creator:: Smith, April G.
Abstract:: Pacific lamprey (Entosphenus tridentatus) are experiencing population declines throughout their range. Xenobiotics could be an important risk factor for lamprey populations. Our goal was to establish if common herbicides, as used in forest management, could affect reproductive fitness. We determined that atrazine was a likely compound of greatest concern to...
Resource Type:: Masters Thesis
Full Text:: goal of this research is to determine if atrazine has an effect on the ability of Pacific lamprey to

Blood-based gene expression as a biodosimetry model for neuroblastoma patients treated with ¹³¹I-mIBG

Creator:: Edmondson, David A.
Abstract:: Internal dosimetry is challenging and relies on estimates using MIRD or ICRP biokinetic models. To address this, we looked at gene expression analysis in whole blood from radiotherapy patients. Patients with relapsed or refractory neuroblastoma who received ¹³¹I-mIBG at UCSF were used to correlate internal ionizing radiation (IR) dose with...
Resource Type:: Masters Thesis
Full Text:: David A. Edmondson for the degree of Master of Science in Radiation Health Physics presented on June 26

Assessing mechanisms of immunotoxicity for polycyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss)

Creator:: Bravo, Claudia F.
Abstract:: During the past 30 years, numerous studies have focused on the toxicities of polycyclic aromatic hydrocarbons (PAH). Laboratory and field studies have helped elucidate the detrimental effects of these chemicals on growth, reproduction and immune response. Polycyclic aromatic hydrocarbons are in the priority list of chemicals to be studied by...
Resource Type:: Dissertation
Full Text:: degree of Doctor of Philosophy in Toxicology presented on December 9. 2005. Title: Assessing Mechanisms

A comparative study of fish coloration and toxicant responses in a chromatophore cell-based biosensor

Creator:: Roach, Holly B.
Abstract:: Detection of both biological and chemical environmental toxicants is essential in the assessment of risk to human health. Cell-based biosensors are capable of activity- based detection of toxicity. Chromatophore cells, responsible for the pigmentation of poikilothermic animal, have shown immense potential as cell-based biosensors in the detection of a broad...
Resource Type:: Masters Thesis
Full Text:: . Roach for the degree of Master of Science in Microbiology presented on March 9, 2012. Title: A

Physical and chemical factors controlling the distribution of the major phytoplankton classes at the Antarctic Polar Front, 170 °W

Creator:: Mengelt, Claudia
Abstract:: This study was part of the Antarctic Environment and Southern Ocean Study (AESOPS) program, whose main goal was to investigate the role of the biota in the carbon flux from the atmosphere to the interior of the ocean. We quantified the abundance of the major phytoplankton classes and examined the...
Resource Type:: Masters Thesis
Full Text:: Mengelt for the degree of Master of Science in Oceanography presented on August 25, 2000. Title

Environmental estrogens and skeletal development disruption in the fathead minnow : A teleost model of vertebrate developmental toxicity

Creator:: Warner, Kara E.
Abstract:: Natural and synthetic estrogenic compounds detected in surface waters have been linked to endocrine signaling disruption in several species. Endogenous estrogen contributes to cartilage and bone deposition during development in vertebrates, and is susceptible to perturbation from xenoestrogens. The goals of this work were to develop a teleost model to...
Resource Type:: Dissertation

Development of a progeny marker for steelhead

Creator:: Shippentower, Gene E.
Abstract:: This study was undertaken to determine if strontium chloride could be used to create a trans-generational otolith mark in steelhead (Oncorhynchus mykiss). I completed two strontium injection trials and a survey of juvenile steelhead from various steelhead hatcheries. The two trials measured Sr:Ca ratios in otoliths in response to injections...
Resource Type:: Masters Thesis
Full Text:: assessed the effect of treatment on the survival and growth of progeny from treated females. Finally, I

Semi-volatile organic compounds and developing organisms : accumulation in California mountain tadpoles in the field and fish embryo exposures in the laboratory

Creator:: Stanley, Kerri A.
Abstract:: The atmospheric transport and deposition of semi-volatile organic compounds (SOCs), including current and historic use pesticides, polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs), to mountain ecosystems may result in the exposure of tadpoles to these SOCs. This exposure has been implicated in amphibian population declines in California. Tadpoles encounter...
Resource Type:: Dissertation
Full Text:: responsible for most of the sediment sample preparation for chemical analysis for Chapter 3. Dr. Robert

Environmental Mixtures and Selected Health Outcomes in the US Population

Creator:: Przybyla, Jennifer
Abstract:: The human health effects of exposure to numerous single environmental contaminants have been well characterized. Yet, biomonitoring studies have detected multiple environmental chemicals in humans, highlighting the need to investigate the health effects of exposure to multiple environmental chemicals. Environmental data is highly complex, therefore current methods of defining environmental...
Resource Type:: Dissertation
Full Text:: ......................................................................... 8 Evaluation of chemical mixtures on human health

Size and surface area dependent toxicity of silver nanoparticles in zebrafish embryos (Danio rerio)

Creator:: Tuttle, George R.
Abstract:: Many studies addressing the toxicity of silver nanomaterials have found that smaller sized silver nanoparticles are usually more toxic to organisms and in cell culture than particles of larger sizes yet it is not entirely clear why. We investigated the size dependent toxicity of silver nanoparticles by measuring the response...
Resource Type:: Masters Thesis
Full Text:: 3.3 Effect of the Chorion on Embryo Toxicity……………………………………………………... 21 TABLE

Assessment of fluorinated chemicals (FCs) on developmental toxicity in embryonic zebrafish

Creator:: Duong, Lisa
Abstract:: Fluorinated chemicals (FCs) have been used since the 1950s in many industrial and commercial applications because of their unique properties such as chemical inertness, resistance to heat and their ability to repel water and oils. Concerns regarding potential environmental or human health risk from FCs exposure have emerged due to...
Resource Type:: Masters Thesis
Full Text:: LIST OF APPENDICES Appendices Page A Chemical data on fluorinated chemicals

Antioxidant enzyme response in rainbow trout (Oncorhynchus mykiss) after subchronic exposure to an environmentally-relevant polycyclic aromatic hydrocarbon mixture

Creator:: Norby, Tyler S.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are significant pollutants in aquatic environments. Many are carcinogenic and lead to DNA fragmentation and adduct formation in marine and freshwater organisms. Previous research demonstrates that rainbow trout (Oncorhynchus mykiss) compensate to long-term PAH dietary exposures and reduce the DNA damage. The aim of this study...
Resource Type:: Masters Thesis
Full Text:: previous research, there was no significant (P > 0.05) effect on body weight of the fish in any of the

Embryonic and Larval Zebrafish Bioassays for Biomedical Research : The Larval Photomotor Response Screening Assay and Phenotype

Creator:: Fisher, Joseph A.
Abstract:: Laboratories around the world are using the zebrafish model for biomedical research and conducting investigations using morphological, physiological, behavioral, and genomic endpoints. All assays provide information, but physiological and behavioral endpoints or phenotypes are a fast way to understand how an animal is responding to its environment. We investigate the...
Resource Type:: Dissertation
Full Text:: the burden-of-proof on the chemical supplier to demonstrate substance health and safety, while in

The effects of environmental stressors on cardiac gene expression and contractility in rainbow trout (Oncorhynchus mykiss)

Creator:: Momoda, Tracey S.
Abstract:: Rainbow trout (Oncorhynchus mykiss) experience a variety of stressors in their natural environment as well as in aquaculture that can have negative effects on their physiology. The effects of physiological stress and endocrine disruption have been well described in fish. However, there is a scarcity of information on the effects...
Resource Type:: Dissertation
Full Text:: expression and stress did not have an effect on EE induced gene expression in the heart of rainbow trout

Agricultural impacts on amphibian survival, growth, and distributions

Creator:: Baker, Nick J.
Abstract:: The potential impact of chemical contaminants and conservation practices on amphibians in agricultural landscapes is a key research topic globally. Amphibians represent a common group in many freshwater systems and are currently experiencing worldwide population declines. Global amphibian declines may be attributed to a number of causes, including habitat loss,...
Resource Type:: Masters Thesis
Full Text:: pesticides and fertilizer chemical classes on survival……........ 61 3.3 Effect of pesticides and fertilizers

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Creator:: Grove, Robert Allan
Abstract:: A large number of river otter (Lontra canadensis) males were collected from areas of high and low contaminant concentrations throughout western Oregon and Washington during the fall and winter of 1994-99. Few significant non-reproductive organ morphometric differences were found in the large series of male otters collected, except for adrenal...
Resource Type:: Dissertation
Full Text:: degree of Doctor of Philosophy in Toxicology presented on May 25, 2006. Title: Environmental Contaminants

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Creator:: Grove, Robert Allan
Abstract:: A large number of river otter (Lontra canadensis) males were collected from areas of high and low contaminant concentrations throughout western Oregon and Washington during the fall and winter of 1994-99. Few significant non-reproductive organ morphometric differences were found in the large series of male otters collected, except for adrenal...
Resource Type:: Dissertation
Full Text:: Page 39 Three dimensional graph showing the predicted effects of increasing 'PCB concentrations on

Analysis of semi-volatile organic contaminants and their accumulation in remote aquatic ecosystems of the western US

Creator:: Ackerman, Luke K.
Abstract:: Many pesticides, polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and polycyclic aromatic hydrocarbons are persistent, bio-accumulative, and toxic. These semi-volatile organic compounds (SOCs) can undergo atmospheric transport and deposition in cold, remote ecosystems. A better understanding of their accumulation in the fish of these ecosystems is important to better predict...
Resource Type:: Dissertation
Full Text:: Chemistry presented on March 29th, 2007. Title: Analysis of Semi-Volatile Organic Contaminants and Their

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