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Creator:: Woo, Youn-Hi
Abstract:: This dissertation details the investigation of an alternate pathway to isoprenoids that occurs in plants and microorganisms, the non-mevalonate pathway. This exploration of the pathway focuses on the second step, the conversion of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methylerythritol-4-phosphate (MEP) by the enzyme DXP isomeroreductase (DXR). These studies led to an appreciation...
Resource Type:: Dissertation
Full Text:: , Dr. Phil Proteau for his support, continual inspiration, and endless patience as a mentor, in

Creator:: Kim, Dojung
Abstract:: This dissertation describes studies of isoprenoid biosynthesis in the phytoflagellate Euglena gracilis. Elucidation of a novel isoprerioid pathway, the 2-Cmethyl-D-erythritol-4-phosphate (MEP) pathway, in addition to the generally known mevalonate (MVA) pathway, led to extensive exploration of the distribution of both pathways in a variety of organisms. To date, photosynthetic eukaryotes...
Resource Type:: Dissertation
Full Text:: thank my major Professor, Philip J. Proteau, for his support, guidance, and patience throughout my

Creator:: Phaosiri, Chanokporn
Abstract:: The discovery of the methylerythritol phosphate pathway (the MEP pathway) as an alternate pathway for isoprenoid biosynthesis in some organisms including most bacteria, malarial parasites and plants, but not in animals, has stimulated extensive studies in this area. Research has revealed the potential of finding novel antibacterials, antimalarial drugs, and...
Resource Type:: Dissertation
Full Text:: foremost, II would like to thank my major professor, Dr. Philip Proteau for his advice, guidance, and

Creator:: Fernandes, Roberta P. M.
Abstract:: In recent years, the methyl erythritol phosphate (MEP) pathway to isoprenoids has been the subject of intensive research. The interest is because isoprenoids have important roles in many cellular processes essential for the survival of several pathogenic organisms, making the inhibition of this pathway an attractive target for the drug...
Resource Type:: Dissertation
Full Text:: Inhibitors. Abstract approved: hilip/(Proteau In recent years, the methyl erythritol phosphate (MEP

Creator:: Yao, Qingmei
Abstract:: The isoprenoid pathway is one of the major biosynthetic pathways of secondary metabolites. Isoprenoids with a C₂₀ skeleton are known as diterpenoids and are derived from the common precursor, geranylgeranyl diphosphate (GGPP). This dissertation describes approaches to discover the diterpene synthase enzymes which provide the backbone structures for pleuromutilin and...
Resource Type:: Masters Thesis
Full Text:: Abstract approved: __________________________________________ Philip J. Proteau The isoprenoid

Creator:: Li, Dong
Abstract:: Coibamide A is a highly methylated cyclic depsipeptide isolated from Panamanian marine filamentous cyanobacteria as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. This structurally unique agent exhibits potent cancer cell toxicity with an unprecedented selectivity profile in the National Cancer Institute (NCI) 60 cell line...
Resource Type:: Dissertation
Full Text:: : Philip J. Proteau Coibamide A is a highly methylated cyclic depsipeptide isolated from Panamanian

Creator:: Rowe, Kirk, 1966-
Abstract:: We exhibit long-lived resonances in scattering from two-dimensional soft cage potentials comprised of three and four Gaussian peaks. Specific low-energy resonances with very narrow width are shown to correspond to classical multiple-reflection events. These states have much larger probability densities inside the cage than outside and mimic bound states in...
Resource Type:: Dissertation
Full Text:: Scattering Wave functions of Two-Dimensional Cage Potentials. Abstract approved: Philip J. Siemens We

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