Human cathelicidin antimicrobial peptide (CAMP/LL-37) is a cationic antimicrobial peptide that is widely expressed by myeloid and epithelial cells at the human-environment interface. It possesses broad spectrum antimicrobial capacity against bacteria, fungi and viruses. In addition to its direct antimicrobial activity, CAMP/LL-37 also attracts and recruits monocytes, neutrophils and other...
An inventor seeks to leverage his unique means in order to create and commercially exploit new technologies. Until new technologies are sufficiently developed, they have the theoretical potential for commercial exploitation in a wide range of markets. Those opportunities are limited by physical bounds that are often only discovered through...
The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) through activation of the vitamin D receptor (VDR) and primary bile salts through activation of the xenobiotic nuclear receptor farnesoid X...
My thesis, entitled “The Clerk’s Tale: Literal Monstrosities and Allegorical Problems,” argues that Chaucer’s Clerk is engaging both sides of a binary system. The Clerk has situated himself in a precarious position between two major schools of thought in the medieval culture, Franciscan and Dominican; the former promotes the will...
My thesis, entitled "Fantastic Histories: How Malory's Morte Darthur
Influenced Tolkien's The Silmarillion," argues that J.R.R. Tolkien's Silmarillion
shares distinct similarities in style and content with Sir Thomas Malory's Morte
Darthur, primarily in the lack of detail in the descriptions of characters and events, as
each attempts to create a...
My thesis explores the later work of author J.D. Salinger, including two narratives featured in Nine Stories, "A Perfect Day for Bananafish," and "Teddy," and Franny and Zooey, "Raise High the Roof Beam, Carpenters," and "Seymour: an Introduction." Through my analysis I argue that the religious nature of Salinger's fiction...
This thesis examines depictions of medievalism in three central texts: Sir Walter Scott's Ivanhoe, Mark Twain's A Connecticut Yankee in King Arthur's Court, and George R.R. Martin's A Game of Thrones. Each of these texts provides an entry point for exploring the ways in which English and American writers have...
This thesis presents two related studies on the methodology for creating, and
subsequently analyzing, an inverse food web model of an intertidal seagrass bed. The first study (Chapter 2) describes, for the first time in the literature, a method for incorporating isotopic information gained from Bayesian mixing models into an...
This work compares the condensation heat transfer and pressure drop for zeotropic refrigerant R-454C and its individual components, R-32 and R-1234yf, in horizontal microfin tubes. One microfin tube has a 4 mm outer diameter, 0.18 mm wall thickness, and a surface area ratio of 1.56. The second tube has a...
The main goal of this project is to implement an algorithmic music composition procedure and present all procedures and results in a reproducible fashion by creating a web application produced by R. To approach the implementation of the algorithmic composition of music, we start by exploring various models, but ultimately...
This research focused on the use of classical and modern two-dimensional spectral estimation techniques for enhancing inverse synthetic aperture radar (ISAR) imagery. 2-D Classical spectral estimation methods and 2-D modern parametric and non-parametric spectral estimation methods are applied to simulated and real data sets in order to achieve both range...
Optimization of reservoir operation is involves various competing objectives for a scarce resource (water). To find the optimal operation of reservoirs, it is essential to consider multiple objectives simultaneously. There are various sources of uncertainty associated with the reservoir operation problem that should be considered as well.
The overarching goal...
As the aging population continues to grow worldwide, age-related complications are becoming more apparent within the aging population. One of the first age-related complications to become apparent is age-associated memory impairment and it can make the elderly more dependent on caregivers early on. The N-methyl-D-aspartate (NMDA) receptor is important to...
Recently, an interest in supplementation of vitamin D to improve aspects of health, especially in human fertility, has emerged. However, supplementation of Vitamin D above the minimum required levels to prevent deficiency has yet to be explored in cattle despite evidence for vitamin D receptors in reproductive tissues. The objective...
This thesis presents a novel algorithmic A/D converter to be used in a biosensor. The converter is capable of a conversion rate of 1.5 bits/phase and hence the required conversion time is reduced. The proposed architecture is analyzed for non-ideal effects and compared with existing algorithmic A/D architectures. The converter...
Studies toward the total syntheses of highly potent cytotoxic alkaloids
including the bromopyrrole alkaloids and indole alkaloids were conducted and are
described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...
Recent interest in oxy-fuel combustion for carbon capture, as well as advancements in technologies such as magnetics, materials, and computational modeling has sparked renewed interest in magnetohydrodynamic (MHD) power generation. The increased temperatures of oxy-fuel combustion versus air-fuel combustion poses a challenge in the selection of materials for plasma exposed...
Cutaneous melanoma remains the deadliest form of skin cancer arising from malignant transformation of pigment-producing melanocytes, with a diagnosis of metastasis indicating a median survival rate of less than a year. Solar ultraviolet (UV) radiation, especially childhood sun exposure, is an important etiological risk factor of melanoma. This DNA damage...
The Cackling goose (Branta hutchinsii minima) population has increased from a low of 20,000 in 1984 to the current population of 220,000-300,000 (Stehn 2012, Sanders 2013). As the Cackling goose population began to recover in the late 1990s, the majority of the population relocated from wintering in California to the...
Third Culture Kids (TCKs) are a rapidly emerging student population within colleges and universities. TCKs must balance the myriad of experiences of growing up among worlds with the amplified implications that it entails as college students (Van Reken & Pollock, 2010). This study attempts to fill the gap between the...
Mold growth on cheddar-style cheese, though not a food safety issue, causes significant loss to the industry due to consumer rejection. For this reason, it is common for at-risk products, such as cheese shreds, to be coated with the mold inhibitor natamycin. While highly effective at extending shelf-life, preferences for...
In nanoscale materials, the Coulombic interaction between electrons are stronger than in bulk materials. These stronger interactions, caused by confinement and reduced dielectric screening, have interesting consequences for light-matter interactions. In carbon nanotubes (CNTs), strong interactions can enhance the impact ionization process, and thus assist photocurrent generation in CNTs. Conversely,...
Connecting with nature is associated with social, physical, and emotional benefits such as stress relief, improved physical health, and lower crime. Parks and other natural areas offer spaces in which to connect with nature and reap these and other benefits (e.g., family bonding, social events, learning). Despite increasing populations of...
Sandy beaches and dunes cover approximately one-third of the world’s ice-free coastlines and provide ecosystem services including coastal protection, recreation, wildlife habitat, and carbon sequestration. These dynamic interface habitats are variably shaped by wind, waves, sedimentary processes, and vegetation feedbacks. Positive biophysical feedbacks lead to the formation of vegetated coastal...
Designation of areas as marine wilderness has been proposed as a strategy for managing the increasing threats facing the world’s oceans. Although social factors influence marine protected area success, the human dimensions of marine wilderness remain minimally explored. This thesis examines views of marine wilderness expressed by a representative sample...
The phantom midges (Diptera: Chaoboridae) are a relatively small fly family composed of 50 extant species in six genera. Larvae are of interest to limnologists and ecologists because of their tolerance to toxicants, predatory avoidance strategies, and the role chaoborids play in zooplankton community dynamics. Relative to mosquitoes, systematists have...
The recently emerged Grapevine Red Botch Virus (GRBV) impedes proper berry ripening primarily by reducing sugar accumulation and color development in red-fruited Vitis vinifera L. cultivars. To date, there is no recommended management strategy for virus spread or the impacts of the disease beyond removal and replacement of infected vines....
The increasing demand for forest products and restricted use of natural forests has resulted in a shortage of high-strength wood fiber. The area covered by plantation forests is steadily rising, but the fiber produced by these forests is often unsuitable for high-strength applications. One attempt to combat this problem is...
Current frameworks for analyzing forest carbon offset projects in disturbance-prone western forests often fail to address the dynamic nature of carbon pathways through time. They do not account for the probability of loss due to wildfire, which can influence the prediction of carbon storage at the end of a planning...
The development of bioenergy from biomass has dominated the minds of forest engineering researchers over the last decade. One of the main themes that has been generated from that research is that bioenergy from biomass has major operational hurdles to overcome before becoming economically feasible. More directly, the impact of...
This dissertation focuses on personal privacy in human-robot interaction, which we call "privacy-sensitive robotics." Our understanding of "privacy" is very broad, including not just information privacy but also physical, psychological, and social privacy. We begin by surveying the scholarly literature on privacy and talking about why it applies to interactions...
Wildfires can affect soil physical properties, resulting in changes in infiltration, hillslope runoff, groundwater recharge, and sediment and dissolved nutrients to streams. In November 2016, the Chimney Tops 2 Fire burned 4,617 ha of Appalachian hardwood forest in eastern Tennessee. A portion of the fire burned through a National Ecological...
The purpose of this study is to critically explore low-income women's experience as they negotiate post secondary education in community colleges. Three research questions explore the context through which low-income women have entered the college experience, what that experience is like for them, and how the community college experience has...
The Second World War was not just a military struggle but also a struggle between two different agriculture, food distribution, and nutrition systems in the United Kingdom and Nazi Germany. At the start of the war, both countries understood that food and nutrition would play an important role and carefully...
This thesis discusses the African American authors Richard Wright and James Baldwin, and their views regarding how literature should be written. These views are examined as laid out in a selection of each author‟s essays, as well as through an analysis of the characters Bigger Thomas and Rufus Scott in...
Landscape level habitat alterations can have different effects on different species. Species that are more highly specialized for some important aspect of their natural history are expected to be more sensitive to habitat alteration than are those that are generalists. The Northern Pygmy-Owl (Glaucidium gnoma) has been suggested as a...
This thesis describes the results of a linear stability analysis conducted on a simulated wind-forced ocean front. The ocean surface boundary layer regulates exchanges between the ocean and atmosphere, and the presence of turbulence in the surface layer can greatly impact climate and ocean life. Past research has shown that...
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Roger M. Samelson Eric D. Skyllingstad
ABSTRACT
This thesis describes the results
As genetically modified products come under greater production, tensions surrounding the potential benefits and harms of the technology have appeared in divergent policy between the European Union (EU) and certain member states. The purpose of this thesis is to consider whether some type of international law, also called an environmental...
Research on the population genetics of microbial organisms requires the use of specialized analyses designed for clonal organisms to avoid violating the assumptions of traditional population genetic models. The tools necessary for performing these analyses existed as a set of unrelated software with non-overlapping capabilities and did not cover all...
In response to the events on September the Eleventh, various media attempted to make sense of the seemingly radical altered political landscape. Comic books, though traditionally framed as low brow pulp, were no exception. This thesis is a work of rhetorical criticism. It applies Walter Fisher's Narrative Paradigm to a...
Signals from the R/V Langseth’s tuned airgun array were recorded on an array of 33 EarthScope FlexArray seismometers deployed in the Oregon Coast Range from 43.5° to 45°N as part of the 2012 Ridge2Trench experiment to image the structure of the Juan de Fuca plate. This segment of the Juan...
The Wetland Reserve Program (WRP) is one conservation tool that mitigates national wetland loss and a primary goal for the program includes optimizing wildlife habitat by restoring wetland functions and values. Few studies have evaluated the WRP, which limits our understanding of its impact on wildlife populations. I assessed the...
Many D2d-symmetric 2,2',6,6'-tetrasubstituted biphenyls are
readily prepared via net oxidative dimerization of appropriate
1,3-disubstituted benzenes. Conversion of such proprochiral
compounds to useful C2-symmetric chiral biphenyls requires
formal replacement of two substituents on opposing aryl ring
units with alternate groups. This under exploited
desymmetrization tactic has been demonstrated for the
generation...
Traditional approaches for the direct preparation of alkenes are unable to fully control either the stereochemical configuration of the carbon-carbon double bond or else the regiochemistry of the substituents surrounding it. The recently introduced concept of carbenoid eliminative cross-coupling (CEXC) offers a remedy to these deficiencies by providing for a...
Current research on the topic of advanced reactor fuel types include the use of ultrahigh density Uranium-Molybdenum fuels, towards their use in high-performance research reactors. These reactors operate with high power densities, and the increased cooling requirements therefore place high relevance on the fluid-structure interaction with these fuel elements; therefore...
Most operating power reactors use oxide fuel in the form of uranium oxide (UO2) which is robust against high temperatures but suffers from poor mechanical performance at high levels of burnup. Currently, the maximum average burnup in light water reactors in the US is 62.5 GWd/t, which is partially imposed...
This dissertation uses manipulative experiments to explore amphibian-Bd infection dynamics. Although there has been almost two decades research since the discovery of Bd, many questions still remain regarding what conditions mediate chytridiomycosis virulence. My research shows how certain host and pathogen factors can influence disease virulence. Identifying how host and...
Pseudomonas is a diverse, ubiquitous, and widely studied genus of bacteria. As Pseudomonas species occupy a wide range of niches in the ecosystem, they have made remarkable biological impacts. Better understanding of Pseudomonas biology, genetic diversity, and functional interactions with other organisms and the environment will provide valuable insights into...
Cabbage maggot, Delia radicum (Diptera: Anthomyiidae) impacts the production of Brassicaceae crops worldwide. The larva feed on the roots of crops causing reductions in yields due to impaired root function and unmarketability of crops. Chemical and cultural management programs are commonly used to control cabbage maggot with varying rates of...
With growing populations and consumer demand, there has been a turn to the deep sea to meet our natural resource needs. The deep sea provides a range of benefits to humans—called ecosystem services—including carbon sequestration, fisheries, waste absorption and detoxification, and nutrient cycling, all of which are vital to life...