Index Catalog // ScholarsArchive@OSU

Development of Simple, Rapid, and Sensitive qPCR Assay for the Detection of Pseudocapillaria tomentosa in Danio rerio Tissue Samples

Creator:: Ramras, Monique A.
Abstract:: Pseudocapillaria tomentosa is a nematode that parasitizes Danio rerio, causing major disease that affects the economic commodities of fish industries and destroys experimental results at research facilities. There is a critical need for a rapid and sensitive diagnostic assay to test for P. tomentosa in D. rerio populations. PCR primers...
Resource Type:: Honors College Thesis
Full Text:: .” Journal of Clinical Investigation, vol. 122, no. 7, 2 July 2012, pp. 2337–2343., doi:10.1172/jci60434

The Cathelicidin Anti-microbial peptide gene alters the mouse gut microbiome

Creator:: Rouches, Miles V.
Abstract:: The gut microbiome influences human disease including Type 2 diabetes, obesity and metabolic syndrome and interacts with the innate immune system. The human cathelicidin antimicrobial peptide (hCAMP), an important component of the innate immune system, and vitamin D and xanthohumol, a natural compound found in beer hops, regulate its expression....
Resource Type:: Honors College Thesis
Full Text:: normal glucose homeostasis. Journal of Clinical Investigation. 2006;116(4):1102-1109. doi:10.1172

Regulation of Skeletal Muscle Insulin Action and Fatty Acid Trafficking with Obesity and Exercise

Creator:: Stierwalt, Harrison D.
Abstract:: Altered skeletal muscle fat metabolism is linked to changes in skeletal muscle insulin sensitivity. Whereby the accumulation of bioactive signaling lipids (i.e., diacylglycerols and ceramides) within skeletal muscle are negatively associated with insulin sensitivity and the exercise-induced changes to fatty acid trafficking are related to improved skeletal muscle insulin action....
Resource Type:: Dissertation

Evaluation of a Monoclonal Antibody for Studying MHC Class I Antigen Presentation In-Vitro

Creator:: VanderHoek, Eden N.
Abstract:: Human epidermal growth factor receptor 2 (HER2), a member of the receptor tyrosine kinase (RTK) family, is frequently dysregulated in a variety of cancers. Overexpression of the receptor leads to increased cell proliferation and resistance to cell death due to downstream signaling effects. Proteasomal degradation of HER2 results in the...
Resource Type:: Honors College Thesis
Full Text:: . 2015, pp. 3335–37. PubMed Central, doi:10.1172/JCI83871.

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks.

Creator:: Choudhury, Mudra
Abstract:: While monocytes are vital for host defense against pathogens, in cases of non-resolving inflammation, monocytes and their differentiated progeny can secrete tissue-damaging factors, present auto-antigens, and promote the inflammatory response. In this study, a systems biology approach was used to map human monocyte gene regulatory regions by integrating expression quantitative...
Resource Type:: Honors College Thesis
Full Text:: differentiation through the forkhead transcription factor Foxp1. J Clin Invest 114:408–18. doi: 10.1172/JCI21100

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks

Creator:: Choudhury, Mudra
Abstract:: While monocytes are vital for host defense against pathogens, in cases of non-resolving inflammation, monocytes and their differentiated progeny can secrete tissue-damaging factors, present auto-antigens, and promote the inflammatory response. In this study, a systems biology approach was used to map human monocyte gene regulatory regions by integrating expression quantitative...
Resource Type:: Honors College Thesis
Full Text:: differentiation through the forkhead transcription factor Foxp1. J Clin Invest 114:408–18. doi: 10.1172/JCI21100

Characterizing the Interaction between BCL11B and TCF-1 transcription factors in the control of the BCL-xL gene

Creator:: Nagra, Alamjit K.
Abstract:: Immature T cells, known as thymocytes, undergo development through successive stages in the thymus and the periphery to become functional mature T cells. These stages are regulated by sequence specific transcription factors (SSTFs). Two such SSTFs, BCL11B and TCF-1, are both known master regulators of thymopoiesis, which is also known...
Resource Type:: Honors College Thesis

Bacterial and Host Factors Contributing to Mycobacterium avium subspecies paratuberculosis Persistent Infection

Creator:: Phillips, Ida L.
Abstract:: Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne’s disease, a chronic granulomatous enteritis that plagues domestic and wild ruminants globally. During the silent stages of Johne’s disease, infected animals intermittently shed bacteria for years prior to clinical diagnosis during advanced disease stages. This strategy allows MAP to...
Resource Type:: Dissertation

Investigation of the Patterns and Transcriptional Regulators from Gene Expression Profiles of Adult Murine Soleus and Tibialis Anterior Skeletal Muscles

Creator:: Alto, Sarah I.
Abstract:: Skeletal muscles provide several functions, including, yet not limited to, voluntary body movement and locomotion, posture and body position, and soft tissue support. Skeletal muscles also play a role in metabolism, requiring energy to facilitate contraction. Each skeletal muscle serves a different purpose despite seeming to perform the same task....
Resource Type:: Dissertation

The Role of Cellular Senescence in the Development of Alzheimer's Disease

Creator:: Riordan, Ruben
Abstract:: Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...
Resource Type:: Dissertation

ScholarsArchive@OSU

Development of Simple, Rapid, and Sensitive qPCR Assay for the Detection of Pseudocapillaria tomentosa in Danio rerio Tissue Samples

The Cathelicidin Anti-microbial peptide gene alters the mouse gut microbiome

Regulation of Skeletal Muscle Insulin Action and Fatty Acid Trafficking with Obesity and Exercise

Evaluation of a Monoclonal Antibody for Studying MHC Class I Antigen Presentation In-Vitro

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks.

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks

Characterizing the Interaction between BCL11B and TCF-1 transcription factors in the control of the BCL-xL gene

Bacterial and Host Factors Contributing to Mycobacterium avium subspecies paratuberculosis Persistent Infection

Investigation of the Patterns and Transcriptional Regulators from Gene Expression Profiles of Adult Murine Soleus and Tibialis Anterior Skeletal Muscles

The Role of Cellular Senescence in the Development of Alzheimer's Disease

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