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Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

Creator:

Blanchard, David, L.

Abstract:

L-pipecolic acid (L-PA) is the higher homolog of proline. It occurs naturally in many organisms, including primates, as an intermediate in lysine degradation. The pathway by which lysine is converted into L-pipecolic acid employs the enzyme Lpipecolate oxidase (L-PO), and appears to be tissue specific to the central nervous system...

Resource Type:

Dissertation
Effects of phenytoin and carbamazepine on calcium transport in Caco-2 cells and pilot study to compare the role of the Chilean and United States pharmacist from the patient perspective

Creator:

von Borstel, Melinda

Abstract:

Adverse effects of anti-epileptic (AED) medications on bone density have been reported since the 1960s. Phenytoin and carbamazepine, two commonly prescribed AED, are frequently associated with osteomalacia including fractures and reduced bone formation. The mechanism by which AED induces bone loss is not fully explained. We sought to determine the...

Resource Type:

Honors College Thesis