Magmatic-hydrothermal ore deposits are giant geochemical anomalies in the earth’s crust most often generated by normal magmatic terrestrial processes. They are often associated with oxidized and hydrous intermediate to highly evolved magmas that have concentrated metals and have the necessary components to efficiently extract and transport them as ascending magmatic-hydrothermal...
Metagenomics has revealed that the marine microbial biosphere is immensely more diverse than originally considered, and is an almost untapped reservoir for the potential discovery of microbial natural products. Despite numerous advances in culturing, biosynthetic engineering and genomic-based screening efforts to uncover much of this diversity in relatively accessible environments,...
Analytical chemistry is an essential qualitative and quantitative tool to describe foods and biomaterials and their changes during production, processing and distribution. In this work, rapid analytical procedures for the extraction and quantification of components in fluid milk and diatom fermentation broth were developed. Analytical methods to measure the concentration...
Increasingly popular methods for managing impacts of tourism in nature-based settings include collaborative and voluntary codes of conduct. In southeast Alaska, for example, the Tourism Best Management Practices (TBMP) in Juneau and Wilderness Best Management Practices (WBMP) in Tracy Arm-Fords Terror Wilderness have been created to address shore and marine...
A blood supply chain (BSC) deals with the collection, processing, storing, and distribution of blood collected from donors and delivered to patients at demand points (DPs) through a network of several temporary mobile blood units (MBUs) and permanent local blood centers (LBCs). In general, the strategic and tactical design of...
This study evaluates ore transport and other mining activities on metal levels in the remote Arctic ecosystem of Cape Krusenstern National Monument (CAKR) in northwestern Alaska. This monument is 50 km SW of Red Dog Mine, one of the world’s largest Pb–Zn mines. The Delong Mountain Transportation System (DMTS) haul...
The Pebble porphyry Cu-Au-Mo deposit in Alaska is one of the world's largest Cu-Au mineral resources. Late Cretaceous magmatic evolution in the Pebble district culminated with the intrusion of the Kaskanak Batholith and associated porphyry copper-gold-molybdenum mineralization. The Kaskanak Batholith is a multiphase granodiorite intrusion with an estimated footprint of...
Microbial natural products represent a massive repository of unique chemical scaffolds with corresponding diverse biological functions. However, in the past decade the development of natural products into new therapeutics has dwindled, in part due to the challenges posed by high rediscovery rates and low throughput associated with classical bioassay-guided fractionation...
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death in the United States. Patients with cirrhosis are more likely to develop HCC. More than 80% of HCC patients are found have preexisting cirrhosis. The prevalence of cirrhosis increased from 0.26% to 0.3.% between 1999 to 2010 and...
A proposed copper mine in Arizona has the potential to be the largest copper producing mine in North America. It is expected to produce over a billion pounds of copper per year, and individually produce more than half of the United State's demand for copper. The operation claims to be...