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  • Deciphering the Function of New Gonorrhea Vaccine Candidates in Cell Envelope Homeostasis

    Creator:
    Baarda, Benjamin I.
    Abstract:
    Neisseria gonorrhoeae is the sexually transmitted pathogen responsible for millions of cases of gonorrhea worldwide each year. Rapidly-spreading antibiotic resistance is diminishing the ability to effectively treat a disease with significant consequences to female and male reproductive health, as well as to neonatal well-being. A protective vaccine has the potential...
    Resource Type:
    Dissertation
    Full Text:
    OF THE DISSERTATION OF Benjamin I. Baarda for the degree of Doctor of Philosophy in

  • Detection, biosynthesis, and structural investigations of naturally occurring alkynes and other microbial metabolites

    Creator:
    Back, Daniel C.
    Abstract:
    Natural products have long been an important source of resources for humans. Many of these compounds possess unique chemical structures and potent biological properties. By targeting natural products with specific chemical properties, we can gain a better understanding of the roles these compounds play in the environment and their interactions...
    Resource Type:
    Dissertation
    Full Text:
    Benjamin Philmus Natural products have long been an important source of resources for humans. Many

  • The role of sigma factors in production of cyanobacterial natural products: Escherichia coli as a heterologous expression host

    Creator:
    Wells, Kaitlyn N.
    Abstract:
    Cyanobacteria represent an underexploited source of bioactive natural products of interest to the pharmaceutical industry. Lack of development of these compounds as drug leads is due mainly to myriad practical problems with the producing strains including long doubling times, genetic intractability, and low compound yields. Previous attempts at heterologous expression...
    Resource Type:
    Honors College Thesis
    Full Text:
    . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 8 ACKNOWLEDGEMENTS To my mentor and advisor, Dr. Benjamin Philmus, I extend my

  • Aiding Plants and Humans by Targeting Virulence Strategies: Investigation of key protein residues involved in toxoflavin production

    Creator:
    Justen, Savannah F.
    Abstract:
    Toxoflavin, a toxic secondary metabolite produced by a variety of bacteria, has been implicated as a causative agent in food poisoning and a virulence factor in phytopathogenic bacteria. This toxin is produced by the tox operon in Burkholderia glumae, in which the encoded protein, ToxD, was previously characterized as essential...
    Resource Type:
    Honors College Thesis
    Full Text:
    approved: Benjamin Philmus Toxoflavin, a toxic secondary metabolite produced by a variety of bacteria

  • Exploring Oregon Teacher Retention: Patterns and Reasons for Teachers' Persistence

    Creator:
    Ewing, Benjamin
    Abstract:
    K-12 teacher retention is an enduring concern in the United States as teachers are vital for educational achievement and change. National trends demonstrate how widespread an issue teacher retention is, yet teacher labor markets remain highly localized and highlight the complexity of teacher retention decisions. We need an improved understanding...
    Resource Type:
    Dissertation
    Full Text:
    . Benjamin Ewing, Author ACKNOWLEDGEMENTS I want to express my immense gratitude to Drs

  • Structure and Dynamics of the Canine (Canis familiaris) Nasal Microbiome

    Creator:
    Knorr, Elizabeth
    Abstract:
    The diverse community of bacteria living within and on host organisms, known as the microbiome, has an important role in maintaining host health. Dysbiosis, known as a change in the healthy community of the microbiome, has been associated with a number of diseases across host organisms and body sites including...
    Resource Type:
    Dissertation
    Full Text:
    Microbiome Abstract approved: ______________________________________________________ Benjamin D

  • Adjacent structure response sensitivity to seismic events using the direct differentiation method

    Creator:
    White, William S.
    Abstract:
    The response of adjacent structural systems to earthquake motions is investigated using the finite element framework OpenSees. Results of sensitivity analyses demonstrate that structural response quantities can increase in either or both of the adjacent structures for specific configurations. The structural models used include steel moment-resisting frames and rigid shear...
    Resource Type:
    Masters Thesis
    Full Text:
    . Benjamin Mason The response of adjacent structural systems to earthquake motions is investigated using

  • Pore Water Pressure Response in Soil During Tsunami Loading : Numerical Formulation and Experimentation

    Creator:
    Abdollahi, Abbas
    Abstract:
    Tsunami loading can cause sediment instability, which can compromise the structural integrity of coastal buildings and infrastructure. To understand the process by which a tsunami can cause sediment instability, it is necessary to understand how the pore water pressure in the soil changes during tsunami loading. Tsunami run-up causes the...
    Resource Type:
    Dissertation
    Full Text:
    approved: H. Benjamin Mason Tsunami loading can cause sediment instability, which can compromise the

  • Coastal Soil and Structure Behavior during Earthquake-Tsunami Multi-Hazards

    Creator:
    Qiu, Yingqing
    Abstract:
    Coastal multi-hazards, i.e., earthquakes followed by tsunamis, induce severe damage to coastal infrastructure. The multi-hazards can cause soil liquefaction, which is one of the major concerns for evaluating sediments transport potential and structure failure mechanisms. The objectives for this work is threefold. First, to build and validate a soil numerical...
    Resource Type:
    Dissertation
    Full Text:
    advisor Professor H. Benjamin Mason, I will not be the current me if without all his mentoring. I learned

  • Tsunami-induced Soil Instability

    Creator:
    Fischer, Rachael Marie
    Abstract:
    Recent tsunami field surveys from the 2011 Great East Japan Earthquake and Tsunami have recorded numerous examples of tsunami-induced soil instability: significant scour around foundations, foundation failure of piles, and other damage caused by liquefaction. From the observations of soil instability leading to the failure of critical coastal structures, it...
    Resource Type:
    Masters Thesis
    Full Text:
    Instability Abstract approved: H. Benjamin Mason Recent tsunami field surveys from the 2011 Great East