The potential for nanomedicine to reduce toxicity and improve therapeutic response to radiation is vast. Clinically, this potential has thus far only begun to be realized with the recent success of the radioenhancing nanoparticle, NBTXR3 by Nanobiotix. Radioenhancing nanoparticles, however, represent only a small class of nanomaterials that may be...
Cell migration is fundamental for physiological processes such as immune re-sponses, wound healing and development. It is also a critical characteristic of metastatic cancer cells. An extensive amount of studies have focused on 2D sub-strates in order to understand the mechanism of cancer metastasis. However, much less is known about...
Cancer cell migration in three-dimensional extracellular matrix is a major cause of death for cancer patients. Although extensive studies have elucidated detailed mechanism of single cell 3D invasion and cell-ECM interaction, 3D collective cancer invasion is still poorly understood. 3D collective migration models have unveiled unexpected degrees of diversity and...
At the intersection of basic science research and clinical relevance, cancer metastasis and cell invasion is a multifaceted problem that has been investigated for the past several decades. Importantly, cancer cell plasticity, the ability of a single cell to change its phenotype without genetic mutations in response to environmental cues,...
The structure and mechanics of tissues affect many important cellular functions such as migration, differentiation, and growth. Mechanical interactions between cells and the extracellular matrix (ECM), as well as ECM-mediated mechanical communication between cells, plays a part in coordinating collective cellular dy- namics during critical processes such as morphogenesis, tissue...
Cell signaling under external stimulation is a critical mechanism that governs many biological processes such as cell proliferation, cell migration, and cell apoptosis, etc. For multicellular organisms, the ability to synchronize heterogeneous individual cellular responses through intercellular communication is crucial to maintain normal functionality. However, even though the biological pathways...
Idaho National Laboratories recently conducted micromechanical testing of nano-recrystallized UO₂ as a part of an ongoing investigation of High Burnup Structure (HBS). The goals of the test were to determine the fracture stress, and the elastic modulus of subdivided grains within UO₂ using ion irradiation rather than neutron irradiation to...
General-purpose Graphics Processing Units (GPGPUs) have become a critical component in high-performance computing (HPC) systems in executing modern computational workloads. The high thread level parallelism (TLP) and programmable shader cores allow thousands of threads to execute in Parallel. The fast-scaling of GPGPUs have increased the demand for performance optimizations on...
As the number of nodes in high-performance computing (HPC) systems continues to grow, it becomes increasingly important to design scalable interconnection network topologies. Prior work has shown promise in adding random shortcuts on top of an existing topology to reduce average hop count and network diameter, but has been limited...
Data centers have seen a rapid growth in recent years as the technology industry is relying more on cloud services. In effect, data centers are paying millions of US $ in energy costs. Several strategies have been proposed to lower the total energy cost at data centers- task migration, server...