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Antioxidant enzyme response in rainbow trout (Oncorhynchus mykiss) after subchronic exposure to an environmentally-relevant polycyclic aromatic hydrocarbon mixture

Creator:: Norby, Tyler S.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are significant pollutants in aquatic environments. Many are carcinogenic and lead to DNA fragmentation and adduct formation in marine and freshwater organisms. Previous research demonstrates that rainbow trout (Oncorhynchus mykiss) compensate to long-term PAH dietary exposures and reduce the DNA damage. The aim of this study...
Resource Type:: Masters Thesis
Full Text:: Aromatic Hydrocarbon Mixture Abstract approved: Lawrence R. Curtis Polycyclic aromatic hydrocarbons

Chlordecone (CD), a mixed steroid X receptor (SXR) and estrogen receptor alpha(ERα) agonist, altered hepatic cholesterol (CH) homeostasis and lipoprotein metabolism

Creator:: Lee, Junga
Abstract:: Overtly non-toxic doses of organochlorine (OC) insecticides perturb lipid homeostasis in mice and rats. To increase understanding of how chlordecone (CD), an OC insecticide, modulates cholesterol (CH) homeostasis, we determined the effect of CD pretreatment on the tissue and hepatic subcellular distribution of exogenous [¹⁴C]CH. Corn oil alone or CD...
Resource Type:: Dissertation
Full Text:: approved: Lawrence R. Curtis

Assessing mechanisms of immunotoxicity for polycyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss)

Creator:: Bravo, Claudia F.
Abstract:: During the past 30 years, numerous studies have focused on the toxicities of polycyclic aromatic hydrocarbons (PAH). Laboratory and field studies have helped elucidate the detrimental effects of these chemicals on growth, reproduction and immune response. Polycyclic aromatic hydrocarbons are in the priority list of chemicals to be studied by...
Resource Type:: Dissertation
Full Text:: ) Abstract approved: Lawrence R. Curtis During the past 30 years, numerous studies have focused on the

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Creator:: Scheri, Richard C.
Abstract:: Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of...
Resource Type:: Dissertation
Full Text:: , Douglas F. Barofsky and Lawrence R. Curtis 14 ABSTRACT The

Semi-volatile organic compounds and developing organisms : accumulation in California mountain tadpoles in the field and fish embryo exposures in the laboratory

Creator:: Stanley, Kerri A.
Abstract:: The atmospheric transport and deposition of semi-volatile organic compounds (SOCs), including current and historic use pesticides, polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs), to mountain ecosystems may result in the exposure of tadpoles to these SOCs. This exposure has been implicated in amphibian population declines in California. Tadpoles encounter...
Resource Type:: Dissertation
Full Text:: : _____________________________________________________________________ Staci L. Massey Simonich Lawrence R. Curtis The atmospheric transport and

Long-term fertilizer input influences total and bioavailable metal in agricultural soils and crops

Creator:: Pérez, Angela L.
Abstract:: Protection of the quality and integrity of food supplies is of global concern. Crops can accumulate non-nutritive and sometimes toxic metals and metalloids. Accumulated metals/metalloids can come in part, from fertilizers, which may contain variable levels of non-nutritive metals or metalloids such as arsenic (As), cadmium (Cd), lead (Pb), nickel...
Resource Type:: Dissertation
Full Text:: . Anderson, Lawrence R. Curtis Protection of the quality and integrity of food supplies is of global

Special Nuclear Material Classification and Mass Content Estimation Using Temporal Gamma-Ray Spectroscopy and Machine Learning Methods

Creator:: Curtis, Jessica R.
Abstract:: Improving the methods used for the detection and estimation of fissile material mass content is essential to nuclear security and safeguards to ensure special nuclear material (SNM) accountability, control, safety and security. With the continued expansion of the nuclear industry and the need for safe management of spent fuel, improving...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Jessica R. Curtis

Structure elucidation of bioactive natural products from Madagascar marine algae and cyanobacteria

Creator:: Andrianasolo, Eric Hajaniriana
Abstract:: This thesis is an investigation of the natural products deriving from marine algae and cyanobacteria and has resulted in the discovery of eleven new secondary metabolites. The structure elucidations of these new molecules were performed using a variety of spectroscopic techniques. Four new macrolides were isolated and characterized from the...
Resource Type:: Dissertation
Full Text:: members, Dr. Gary DeLander, Dr. Philip Proteau, Dr. Max Deinzer and Dr. Lawrence Curtis for their time

Spatial and temporal variations of bioavailable polycyclic aromatic hydrocarbons in the lower Willamette River

Creator:: Sower, Gregory J.
Abstract:: Urban rivers with a history of industrial use can exhibit spatial and temporal variations in contaminant concentrations that may significantly affect risk evaluations and assessment of remediation efforts. To more effectively estimate human and ecological health risks, we evaluated the spatial and temporal distribution of polycyclic aromatic hydrocarbons (PAHs) in...
Resource Type:: Dissertation
Full Text:: the time and effort my committee put into this work (Larry Curtis, Staci Simonich, Dave Williams and

Evidence for the involvement of a mitochondrial permeability transistion in a victorin-Induced cell death

Creator:: Curtis, Marc James
Abstract:: Production of the host selective toxin victorin is causal to pathogenesis of Cochliobolus victoriae on oats. The dominant Vb gene confers oat sensitivity to victorin, and is genetically inseparable from Pc2, which confers resistance to Puccinia coronata f. sp. avena. Victorin induces apoptotic-like cell death, and cell death is a...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Marc James Curtis for the

ScholarsArchive@OSU

Antioxidant enzyme response in rainbow trout (Oncorhynchus mykiss) after subchronic exposure to an environmentally-relevant polycyclic aromatic hydrocarbon mixture

Chlordecone (CD), a mixed steroid X receptor (SXR) and estrogen receptor alpha(ERα) agonist, altered hepatic cholesterol (CH) homeostasis and lipoprotein metabolism

Assessing mechanisms of immunotoxicity for polycyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss)

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Semi-volatile organic compounds and developing organisms : accumulation in California mountain tadpoles in the field and fish embryo exposures in the laboratory

Long-term fertilizer input influences total and bioavailable metal in agricultural soils and crops

Special Nuclear Material Classification and Mass Content Estimation Using Temporal Gamma-Ray Spectroscopy and Machine Learning Methods

Structure elucidation of bioactive natural products from Madagascar marine algae and cyanobacteria

Spatial and temporal variations of bioavailable polycyclic aromatic hydrocarbons in the lower Willamette River

Evidence for the involvement of a mitochondrial permeability transistion in a victorin-Induced cell death

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