Index Catalog // ScholarsArchive@OSU

Syntheses and evaluation of putative enzyme inhibitor of isoprenoid biosynthesis

Creator:: Phaosiri, Chanokporn
Abstract:: The discovery of the methylerythritol phosphate pathway (the MEP pathway) as an alternate pathway for isoprenoid biosynthesis in some organisms including most bacteria, malarial parasites and plants, but not in animals, has stimulated extensive studies in this area. Research has revealed the potential of finding novel antibacterials, antimalarial drugs, and...
Resource Type:: Dissertation
Full Text:: of Putative Enzyme Inhibitors of Isoprenoid Biosynthesis Abstract approved: Philip The discovery

Studies of non-mevalonate isoprenoid biosynthesis : the 1-deoxy-D-xylulose-5-phosphate isomeroreductase (DXR) mediated reaction

Creator:: Woo, Youn-Hi
Abstract:: This dissertation details the investigation of an alternate pathway to isoprenoids that occurs in plants and microorganisms, the non-mevalonate pathway. This exploration of the pathway focuses on the second step, the conversion of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methylerythritol-4-phosphate (MEP) by the enzyme DXP isomeroreductase (DXR). These studies led to an appreciation...
Resource Type:: Dissertation

Studies on 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Synechocystis sp. PCC6803 : characterization of mutants and inhibitors

Creator:: Fernandes, Roberta P. M.
Abstract:: In recent years, the methyl erythritol phosphate (MEP) pathway to isoprenoids has been the subject of intensive research. The interest is because isoprenoids have important roles in many cellular processes essential for the survival of several pathogenic organisms, making the inhibition of this pathway an attractive target for the drug...
Resource Type:: Dissertation

Solution deposition and characterization of the thin film inorganic materials

Creator:: Özmen, Bahar
Abstract:: The general emphasis of this work has been synthesis, characterization, and applications of n- and p-type inorganic oxide thin films that are deposited from solutions. In particular, a study of n-type transparent semiconductor films of tin (IV) oxide and zinc-doped tin (IV) oxide has been performed by spin coating. Solution...
Resource Type:: Masters Thesis
Full Text:: for 60 min at 450C in an ultrasonic bath containing Conrad 70. The substrates are washed with

Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

Creator:: Blanchard, David, L.
Abstract:: L-pipecolic acid (L-PA) is the higher homolog of proline. It occurs naturally in many organisms, including primates, as an intermediate in lysine degradation. The pathway by which lysine is converted into L-pipecolic acid employs the enzyme Lpipecolate oxidase (L-PO), and appears to be tissue specific to the central nervous system...
Resource Type:: Dissertation
Full Text:: : Dr. Philip Proteau, Dr. Taifo Mahmud, Dr. Xihou Yin, and Dr. Thomas Savage for their proofreading

Graphite intercalation compounds containing fluoroanions

Creator:: Katinonkul, Watcharee
Abstract:: New chemical synthesis strategies have been investigated for the preparation of acceptor-type graphite intercalation compounds (GIC's) with fluoroanions in order to obtain new materials and to develop a better understanding of the synthetic approaches and properties of the products. New GIC's containing borate chelate anion such as bis(oxalato)borate, CxB[OC(O)C(O)O]₂•δF, are...
Resource Type:: Dissertation
Full Text:: I would like to thank Drs. Kevin Gable, Douglas Keszler, Philip Watson, and Jim McManus for

The visualization of perspective systems and iconology in Dürer’s cartographic works : an in-depth analysis using multiple methodological approaches

Creator:: Wörz, Adèle Lorraine
Abstract:: This dissertation uses a new methodological approach for an in-depth analysis of three cartographic works. Studies within the discipline of the history of cartography have followed various methodologies throughout the past century. This dissertation argues that in order to come to a more complete understanding of how maps were produced...
Resource Type:: Dissertation
Full Text:: , which were co-authored by Johannes Stabius and Conrad Heinfogel. Despite the collaborative nature of

Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

Creator:: Carpenter, Evan L.
Abstract:: Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage and elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments and distributing them to adjacent skin cells (e.g.,...
Resource Type:: Dissertation
Full Text:: project. Dr. Philip Moos provided the TXNRD1 knockdown PIG1 immortalized melanocytes needed for an

Fish Tales: Salmon Stories, 1945-1980

Creator:: Finley, Carmel
Abstract:: Approximately $1 billion a year is spent on salmon in the Pacific Northwest. Spending has escalated, yet the number of wild runs placed under the protection of the Endangered Species Act has increased, creating social and political controversy. For more than 100 years, salmon management in the Pacific Northwest has...
Resource Type:: Masters Thesis

Experimental Investigations of the Unsteady Aerodynamics of Oscillating Airfoils Operating in the Energy Harvesting Regime

Creator:: Siala, Firas F.
Abstract:: The rising global trend to reduce dependence on fossil fuels has provided significant motivation toward the development of alternative energy conversion methods and new technologies to improve their efficiency. Recently, oscillating energy harvesters have shown promise as highly efficient and scalable turbines, which can be implemented in areas where traditional...
Resource Type:: Dissertation
Full Text:: , while χ > 1 corresponds to energy extraction (Kinsey & Dumas, 2008). In words, for an airfoil to extract

ScholarsArchive@OSU

Syntheses and evaluation of putative enzyme inhibitor of isoprenoid biosynthesis

Studies of non-mevalonate isoprenoid biosynthesis : the 1-deoxy-D-xylulose-5-phosphate isomeroreductase (DXR) mediated reaction

Studies on 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Synechocystis sp. PCC6803 : characterization of mutants and inhibitors

Solution deposition and characterization of the thin film inorganic materials

Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

Graphite intercalation compounds containing fluoroanions

The visualization of perspective systems and iconology in Dürer’s cartographic works : an in-depth analysis using multiple methodological approaches

Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

Fish Tales: Salmon Stories, 1945-1980

Experimental Investigations of the Unsteady Aerodynamics of Oscillating Airfoils Operating in the Energy Harvesting Regime

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