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Filtering by: Subject Isopentenoids -- Synthesis Remove constraint Subject: Isopentenoids -- Synthesis License All rights reserved Remove constraint License: All rights reserved

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Syntheses and evaluation of putative enzyme inhibitor of isoprenoid biosynthesis

Creator:

Phaosiri, Chanokporn

Abstract:

The discovery of the methylerythritol phosphate pathway (the MEP pathway) as an alternate pathway for isoprenoid biosynthesis in some organisms including most bacteria, malarial parasites and plants, but not in animals, has stimulated extensive studies in this area. Research has revealed the potential of finding novel antibacterials, antimalarial drugs, and...

Resource Type:

Dissertation
Studies on isoprenoid biosynthesis in Euglena gracilis

Creator:

Kim, Dojung

Abstract:

This dissertation describes studies of isoprenoid biosynthesis in the phytoflagellate Euglena gracilis. Elucidation of a novel isoprerioid pathway, the 2-Cmethyl-D-erythritol-4-phosphate (MEP) pathway, in addition to the generally known mevalonate (MVA) pathway, led to extensive exploration of the distribution of both pathways in a variety of organisms. To date, photosynthetic eukaryotes...

Resource Type:

Dissertation
Studies on 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Synechocystis sp. PCC6803 : characterization of mutants and inhibitors

Creator:

Fernandes, Roberta P. M.

Abstract:

In recent years, the methyl erythritol phosphate (MEP) pathway to isoprenoids has been the subject of intensive research. The interest is because isoprenoids have important roles in many cellular processes essential for the survival of several pathogenic organisms, making the inhibition of this pathway an attractive target for the drug...

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Dissertation
Studies of non-mevalonate isoprenoid biosynthesis : the 1-deoxy-D-xylulose-5-phosphate isomeroreductase (DXR) mediated reaction

Creator:

Woo, Youn-Hi

Abstract:

This dissertation details the investigation of an alternate pathway to isoprenoids that occurs in plants and microorganisms, the non-mevalonate pathway. This exploration of the pathway focuses on the second step, the conversion of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methylerythritol-4-phosphate (MEP) by the enzyme DXP isomeroreductase (DXR). These studies led to an appreciation...

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Dissertation

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Academic Affiliation

College of Pharmacy4

Advisor

Proteau, Philip J.4

Commencement Year

Commencement Year range begin – Commencement Year range end

Current results range from 2003 to 2005

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Committee Member

Gerwick, William2
Gerwick, Bill1
Horne, David1
Hsu, Victor1
Mahmud, Taifo1
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Creator

Fernandes, Roberta P. M.1
Kim, Dojung1
Phaosiri, Chanokporn1
Woo, Youn Hi1

Date

Date range begin – Date range end

Current results range from 2002 to 2005

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Decade

2000-20094

Degree Field

Pharmacy4

Degree Level

Doctoral4

Degree Name

Doctor of Philosophy (Ph.D.)4

Language

English [eng]4

License

All rights reserved[remove]4

Non-Academic Affiliation

Oregon State University. Graduate School4

Peer Reviewed

No4

Resource Type

Dissertation4

Rights Statement

In Copyright4

Subject

Isopentenoids -- Synthesis2
Isopentenoids -- Synthesis -- Inhibitors2
Enzyme inhibitors1
Euglena gracilis -- Metabolism1
Isomerases -- Inhibitors1
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