Otoferlin is a C2-domain, transmembrane protein whose mutated form is responsible for the DFNB9 subtype of prelingual hearing impairment. Mutations in otoferlin cause an autosomal recessive, non-syndromic form of deafness that is characterized by auditory neuropathy/ auditory dissynchrony (AN/AD), meaning that the outer hair cells (OHCs) are normal, and the...
The primary goal of my studies was to elucidate the mechanisms for the well-recognized interaction between two nutrients, vitamins E and K. The outcomes from my studies assess mechanisms for adverse effects of vitamin E and provide novel information on mechanisms for vitamin K homeostasis. These findings will provide information...
The complexity of forest management has increased with the scope of resources of concern and the level of scrutiny from stakeholders. The design and use of specialized computer software, often referred to as “decision support systems” (DSS), is one method for helping managers deal with this complexity. DSS have proven...
Using the historical range of forest conditions as a reference for managing landscapes has been proposed as a "coarse-filter" approach to biodiversity conservation. By emulating historical disturbance processes, it is thought that forest management can produce forest composition and structure similar to the conditions that once supported the native biota....
Forested lands of western Oregon provide aquatic habitat for many fish and riparian dependent species, including a wide variety of salmon species. Current policies set riparian protections using fixed buffers on streams for federal and private lands based on stream type or size. These buffers can create a series of...
Load flow studies are one of the most essential engineering applications for grid operators because they provide a clear picture of the operating conditions of the power system. Traditionally, the load flow problem is assumed to be deterministic; that is, the system variables contain no randomness. Unfortunately, this assumption is...
Recent interest in oxy-fuel combustion for carbon capture, as well as advancements in technologies such as magnetics, materials, and computational modeling has sparked renewed interest in magnetohydrodynamic (MHD) power generation. The increased temperatures of oxy-fuel combustion versus air-fuel combustion poses a challenge in the selection of materials for plasma exposed...
Within The Lamplighter, a novel written in 1854, Maria
Susanna Cummins defines a version of the sentimental novel
that significantly differs from the prescriptive analysis
male critics have offered for the genre. This thesis
argues that feminist theory and recent rhetorical theory
have caused a critical paradigm shift that has...
This dissertation investigates the effect of endogenous and exogenous events on firm behavior and performance. These are fundamental questions in economics. The contribution of this study is threefold. First, it provides estimates of the impact of mergers on railroad efficiency, which has important antitrust implications. Second, it provides new estimates...
From July to September, 2002 I spent ten weeks in Kenya conducting full-time research on the macroeconomic impact of HIV/AIDS and community action towards combating the epidemic in locations dominated by members of the Luo tribe in Nyanza Province, Kenya. Gathering data from both the Ministry of Health and non-governmental...