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Intensification of Solvent Extraction in an Additively Manufactured Microfluidic Separator

Creator:

Touma, Jad George, Coblyn, Matthew, Freiberg, Lucas Joseph, Kowall, Cliff, Zoebelein, Avaline, and Jovanovic, Goran Nadezda

Abstract:

Solvent extraction is an integral chemical and biochemical separation process that is drastically intensified in microfluidic systems. A novel high-throughput micro-separator was additively manufactured for the intensification of liquid–liquid separation. The micro-posts array within the flow plate generated a capillary pressure gradient on the non-wetting organic phase, enabling continuous, membrane-free,...

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10.9 mN/m, and aque- ous:organic inlet flow ratios of 1:1 and 2:1. Separation performance deteriorated
Targeted Nanocarriers for Systemic Delivery of IRAK4 Inhibitors to Inflamed Tissues

Creator:

Park, Youngrong, Korzun, Tetiana, Moses, Abraham S., Singh, Prem, Levasseur, Peter R., Demessie, Ananiya A., Sharma, Kongbrailatpam Shitaljit, Morgan, Terry, Raitmayr, Constanze J., Avila, Uriel, Sabei, Fahad Y., Taratula, Olena R., Marks, Daniel L., and Taratula, Oleh

Abstract:

Persistent and uncontrolled inflammation is the root cause of various debilitating diseases. Given that interleukin-1 receptor–associated kinase 4 (IRAK4) is a critical modulator of inflammation, inhibition of its activity with selective drug molecules (IRAK4 inhibitors) represents a promising therapeutic strategy for inflammatory disorders. To exploit the full potential of this...

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Article

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) and TNF-α (c). Scale bars = 200 μm. Examined colons were collected from healthy mice (Control), and

ScholarsArchive@OSU

Intensification of Solvent Extraction in an Additively Manufactured Microfluidic Separator

Targeted Nanocarriers for Systemic Delivery of IRAK4 Inhibitors to Inflamed Tissues

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