This study investigated the impact of organic chromium (Cr) supplementation and flaxseed on live performance, carcass yield, serum metabolites, muscle lipid profile, histopathological aspects, and meat quality parameters. Ninety (n=90), day-old Cobb chicks were fed a corn-soybean meal-based diet containing 0% flaxseed (Control), 10% flaxseed (Diet 1) and Diet 1...
Ulcerative dermatitis (UD) is a common condition in C57BL/6 mice that is poorly understood and challenging to treat. Inconsistently there have been reports of an increased incidence of the disease in female mice, mice exposed to certain diets, mice of advanced age, and in several seasons. These inconsistencies indicated a...
Early life stages of many marine and diadromous fish species use sandy beach surf zones, which occur along >50% of the world's marine coastlines. This extensive habitat can provide juvenile fishes with an abundant supply of potential prey and the ability to hide from predators in its shallow turbid waters....
The Human Immunodeficiency Virus -1 (HIV-1) has been the source of substantial human misery since it was first discovered in the early 1980s. Despite remarkable progress that has been made towards understanding HIV- 1, there is no cure, no vaccine and life-prolonging therapies are beyond the reach of millions in...
The phenomenon of phantom limb pain has been well documented for centuries, but little clinical work has been done to alleviate it. Physician and neuroscientist Vilayanur S. Ramachandran began researching this condition nearly two decades ago, and has discovered a promising alternative treatment: mirror-box therapy. This therapy is not yet...
Otoferlin is a C2-domain, transmembrane protein whose mutated form is responsible for the DFNB9 subtype of prelingual hearing impairment. Mutations in otoferlin cause an autosomal recessive, non-syndromic form of deafness that is characterized by auditory neuropathy/ auditory dissynchrony (AN/AD), meaning that the outer hair cells (OHCs) are normal, and the...
Fire is an important disturbance mechanism in big sagebrush (Artemisia
tridentata) communities, yet little is known about wildlife population dynamics during
post-fire habitat succession. I estimated the abundance of small mammals and birds in
relation to fire history in mountain big sagebrush (A.t. spp. vaseyana) communities on the
Sheldon National...
Endothelial activation with increased expression of cellular adhesion molecules, chemokines and pro-inflammatory cytokines critically contributes to vascular inflammation and the initiation and progression of atherosclerosis. By affecting redox-sensitive cell signaling pathways and transcription factors, redox-active transition metal ions, such as copper and iron, may play an important role in these...
Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled
signaling pathways. Prior research suggested that some isoforms of PLC-β may exist
and function as dimers, but little is known about dimerization of PLC-β. Data from coimmunoprecipitation
assays of differentially-tagged PLC-β constructs and sizeexclusion
chromatography of native PLC-β support homodimerization...
Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'.
The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...