Index Catalog // ScholarsArchive@OSU

A robust Mycobacterium smegmatis Assay for the Discovery of Anti-tubercular Metabolites from Soil Bacteria

Creator:: Chen, Kathryn P
Abstract:: Tuberculosis (TB) is a pressing global health issue with approximately one third of the world’s population infected by this bacterium. As one of the most dangerous infectious diseases, it has killed approximately 1.7 million people of all ages around the world per year (World Health Organization, 2016). Currently, several drugs...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kerry McPhail, Committee Member, representing Pharmaceutical Sciences

Fungal Secondary Metabolism of Basidiobolus meristosporus: a Novel Natural Product Reservoir

Creator:: Trautman, Ian A.
Abstract:: Secondary metabolites (SMs) play an integral role in the life history of most fungal species. Fungal metabolomic studies provide insights into how fungi perform certain ecological functions, how they compete and interact with other organisms, and the breadth of fungal chemodiversity. Fungal SMs have also been utilized for a variety...
Resource Type:: Masters Thesis
Full Text:: as a researcher. To Dr. Kerry McPhail for guiding me through the world of natural products and for

Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Creator:: Snyder, Kevin M.
Abstract:: In this report, three studies are presented that aid in the development of drug discovery and their synthesis. In each, the importance of the marriage between computations and experiments is highlighted. Continued efforts in this vein are essential for future efforts towards improving human health. The first case study investigated...
Resource Type:: Masters Thesis
Full Text:: . Kerry L. McPhail, and Prof. Paul Ha-Yeon Cheong contributed in part to the preparation and review of

Synthesis, characterization, and analysis of nitroaromatic compounds

Creator:: McIntosh, Melissa Luana
Abstract:: Nitroaromatic compounds have important chemical applications and can be found in nature as pollution sources. Synthetic nitroaromatic compounds have been used in a variety of materials including explosives, pharmaceuticals, dyes, plastics, and pesticides. These compounds can find their way into the environment through normal or improper disposal methods. Poly-aromatic compounds...
Resource Type:: Masters Thesis
Full Text:: two such brilliant professionals. I would like to thank my committee members Professor Kerry

Biogeochemical Processing of Freshwater Carbon in the Anthropocene

Creator:: Buser, Jessica Z.
Abstract:: Freshwater systems cycle carbon along a spatial and temporal biogeochemical continuum, across which ecosystem processes contribute to transformations of organic matter (OM). Various ecological constraints impact rates OM transformation and production and consumption of the energetic end of respiration, methane. Microbiological processing and complete reduction of carbon substrates to methane...
Resource Type:: Dissertation
Full Text:: biogeochemist. This includes but is not limited to my committee Byron Crump, Kim Halsey, Laura Lapham, Kerry

Detection, biosynthesis, and structural investigations of naturally occurring alkynes and other microbial metabolites

Creator:: Back, Daniel C.
Abstract:: Natural products have long been an important source of resources for humans. Many of these compounds possess unique chemical structures and potent biological properties. By targeting natural products with specific chemical properties, we can gain a better understanding of the roles these compounds play in the environment and their interactions...
Resource Type:: Dissertation
Full Text:: . Kerry McPhail and Dr. Aleksandra Sikora, I am thankful for all of the conversations we have shared and

Studies on the ecological functions of the antidiabetic drugs acarbose

Creator:: Tanoeyadi, Samuel
Abstract:: Natural products (a.k.a. secondary metabolites) are produced by living organisms that are not essential for their growth, development, or reproduction, but may play a role in their survival or adaptability in nature. Many secondary metabolites isolated from plants and microbes have found use as molecular probes, drug leads, or medicine...
Resource Type:: Masters Thesis
Full Text:: through my master’s thesis project. I want to also thank all my committee members, Dr. Kerry McPhail, Dr

A Pyrone Diels–Alder Approach to Substituted Indoles and Carbazoles and the Synthesis of New Ropinirole Analogues

Creator:: Points, Gary L., III
Abstract:: Aromatic heterocycles are core structural motifs in natural products, pharmaceuticals and biological polymers. Indoles, in particular, represent a significant subclass of aromatic heterocycles, both in terms of sheer numbers, but also in biological and pharmaceutical relevance. As such, new methodologies for the synthesis of indoles represent an important and continually...
Resource Type:: Dissertation

Non-viral Vectors for Ocular Gene Delivery

Creator:: Herrera-Barerra, Marco, F.
Abstract:: Nucleic acid therapeutics has cemented itself as one of the most efficacious and robust avenues for treatment of a wide range of diseases from vaccine development to treatment of liver, retina, cancer applications. Non-viral mediated gene delivery using lipid-based nanoparticle (LNP) carriers has proven its compatibility with addressing unexpected, fast...
Resource Type:: Dissertation

Investigating Transcriptional Control of Specialized Gene Expression in Plants

Creator:: Fraser, Valerie N.
Abstract:: Specialized or secondary metabolism is a collection of pathways and small molecules that, while beneficial to an organism, are not strictly necessary for survival. Plants use secondary metabolites to, among other things, attract pollinators, defend against biotic and abiotic stressors, and form symbioses. Natural products from plants have seen an...
Resource Type:: Dissertation
Full Text:: , and Dr. Kerry McPhail—thank you for your personal and professional mentorship and support, as well

ScholarsArchive@OSU

A robust Mycobacterium smegmatis Assay for the Discovery of Anti-tubercular Metabolites from Soil Bacteria

Fungal Secondary Metabolism of Basidiobolus meristosporus: a Novel Natural Product Reservoir

Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Synthesis, characterization, and analysis of nitroaromatic compounds

Biogeochemical Processing of Freshwater Carbon in the Anthropocene

Detection, biosynthesis, and structural investigations of naturally occurring alkynes and other microbial metabolites

Studies on the ecological functions of the antidiabetic drugs acarbose

A Pyrone Diels–Alder Approach to Substituted Indoles and Carbazoles and the Synthesis of New Ropinirole Analogues

Non-viral Vectors for Ocular Gene Delivery

Investigating Transcriptional Control of Specialized Gene Expression in Plants

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