Novel mucosal vaccines (LL-M2e, LL-HAe, SG-HAe) were constructed from live, non-pathogenic Lactococcus lactis or Streptococcus gordonii that express conserved regions of HA or M2 antigens from avian influenza virus (AIV) A. All three vaccines evoked antigen-specific serum immunoglobulin G (IgG) responses in vaccinated chickens. The addition of the adjuvant cholera...
Vitamin E was first described in 1922 as an unknown factor required for impregnated rats to carry their offspring to term. In fact, when vitamin E was chemically characterized it was given the name "tocopherol" derived from the Greek: tokos = childbirth; phero = to bear; and –ol, indicating an...
The primary goal of my study was to evaluate the effects of high dietary vitamin E on the rodent skeleton. The outcomes from my study assess the impact of high intakes of vitamin E and increased concentrations of its metabolite, carboxy ethyl hydroxy chromanol (CEHC), on bone turnover and skeletal...
In rats, sesame lignans increase plasma γ-tocopherol concentrations and inhibit γ-tocopherol degradation to its metabolite γ-carboxyethylhydroxychroman (γ-CEHC). To test if sesame lignan consumption inhibits γ- tocopherol metabolism in humans, muffins prepared with either corn oil (control) or sesame oil and an equimolar mixture of deuterium labeled d6-α- and d2-γ- tocopheryl...
We have previously shown that diets enriched with (n-3) fatty acids reduced the delayed-type hypersensitivity (DTH) skin reaction to keyhole limpet haemocyanin (KLH) in geriatric-Beagles. Although the amount of α-tocopheryl acetate in diets of the previous study exceeded requirements, plasma α-tocopherol concentration was significantly lower in dogs fed the high...
When Biosand filters cannot be constructed with crushed quarry rock due to resource limitations, a suitable alternative filter media is needed. In this research, two crushed quarry rock alternatives were examined. Three bench-scale Biosand filters with crushed rock, beach sand, and heat-treated beach sand media were simultaneously dosed with Willamette...
The primary goal of my studies was to elucidate the mechanisms for the well-recognized interaction between two nutrients, vitamins E and K. The outcomes from my studies assess mechanisms for adverse effects of vitamin E and provide novel information on mechanisms for vitamin K homeostasis. These findings will provide information...
Influenza A and Respiratory Syncytial Virus (RSV) are both enveloped, negative strand
RNA viruses which infect the respiratory mucosa of animals and humans. Despite
decades of research and development of antivirals and vaccines, both of these viruses
continue to be a major health concern throughout the world. The focus of...
The immobilization of chelators to solid supports has recently gained renewed interest due to the increasing biomedical and environmental applications made possible by these molecules’ ability to bind Fe(III) and other metal ions. The uses of immobilized chelators have expanded to include the treatment of metal overload in serum, the...