The development of analytical methods for emerging contaminants creates many unique challenges for analytical chemists. By their nature, emerging contaminants have inherent data gaps related to their environmental occurrence, fate, and impact. This dissertation is a compilation of three studies related to method development for the structural identification of emerging...
The near-surface region of a coastal sediment bed is complex and dynamic. At some sites, near-surface sediment deposits are susceptible to extreme events, such as tsunamis or other large overflows, which induce high shear stresses on the sediment bed. The specific properties of sediment beds subjected to such extreme loading...
The diverse community of bacteria living within and on host organisms, known as the microbiome, has an important role in maintaining host health. Dysbiosis, known as a change in the healthy community of the microbiome, has been associated with a number of diseases across host organisms and body sites including...
The response of adjacent structural systems to earthquake motions is investigated using the finite element framework OpenSees. Results of sensitivity analyses demonstrate that structural response quantities can increase in either or both of the adjacent structures for specific configurations. The structural models used include steel moment-resisting frames and rigid shear...
The present study seeks to develop a functional behavior assessment interview (FBAI) that would allow elementary aged students to participate in the assessment process. In particular, the assessment will address if elementary students are able to accurately predict the causes of their problem behaviors and identify when they are likely...
During the 2011 Great East Japan Earthquake and Tsunami, numerous bridge structures were damage or destroyed. The damage to bridge systems was caused by long duration strong ground shaking, tsunami inundation forces, or both. Long duration strong ground shaking from subduction zone earthquakes and the multi-hazard scenario of combined earthquake...
Earthquake engineering analyses are often performed using shallow, crustal earthquake motions (e.g., 1940 El Centro). However, large areas of the world are subject to subduction zone earthquake motions (e.g., the Pacific Northwest). A subduction zone earthquake motion is characterized by its long duration (e.g., strong shaking lasts for more than...
Natural products have long been an important source of resources for humans. Many of these compounds possess unique chemical structures and potent biological properties. By targeting natural products with specific chemical properties, we can gain a better understanding of the roles these compounds play in the environment and their interactions...
Cyanobacteria represent an underexploited source of bioactive natural products of interest to the pharmaceutical industry. Lack of development of these compounds as drug leads is due mainly to myriad practical problems with the producing strains including long doubling times, genetic intractability, and low compound yields. Previous attempts at heterologous expression...
Toxoflavin, a toxic secondary metabolite produced by a variety of bacteria, has been implicated as a causative agent in food poisoning and a virulence factor in phytopathogenic bacteria. This toxin is produced by the tox operon in Burkholderia glumae, in which the encoded protein, ToxD, was previously characterized as essential...