An increase in anthropogenic activities since the industrial revolution, primarily due to burning of fossil fuels and changes in land cover, has resulted in a steady increase in the global mean atmospheric CO2 concentrations. While there is unequivocal scientific evidence on global warming and its multidimensional impacts on natural and...
More than 30 members of the diverse amphidinolide family of biologically active macrolides have been isolated over last three decades. From this family, amphidinolides C and F stand among the most complex and densely functionalized affiliates. Recently, we have accomplished the first total synthesis of amphidinolide F. The all-carbon framework...
The structural architecture present in marine toxin azaspiracid - 20 stereocenters, 9 rings, 3 separated spirocenters - has attracted considerable synthetic attention. Our efforts toward the synthesis of azaspiracid have led to the completion of both C₁-C₂₆ northern and C₂₇-C₄₀ southern halves. Herein, the
synthesis of southern FGHI ring system...
Thomas Stearns Eliot’s 1922 modernist poem The Waste Land presents itself as an alternative to the decaying society Eliot found himself inhabiting. It begins as a personal means of pulling together one’s fragmented consciousness, but in doing so Eliot manages to present a solution to a world of selfishness—looking beyond...
The central purpose of this dissertation was to explore and expand the use of
an uniform electric field for orientation and for subsequent spectroscopic investigation of asymmetric polar molecules in the gas phase. The systems of study were nitrobenzene (NB) and the nitrotoluene (NT) isomers. We were able to quantitatively...
Studies towards the total synthesis of (-)-gymnodimine (1), a marine neurotoxin with a unique molecular architecture and pronounced biological activity, are described. These studies resulted in a convergent approach to the advanced intermediate 315, containing the C3-C32 section of 1. Two synthetic routes were developed to construct the tetrahydrofuran subunit...