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Creator:: Long, Dani M.
Abstract:: Circadian clocks coordinate molecular, cellular, physiological, and behavioral processes with the 24-hour solar day. While clock functions are well understood in young animals, it is not clear how aging or neurodegenerative disease affects the various levels of the circadian system. A common symptom of many neurodegenerative diseases including Alzheimer’s disease...
Resource Type:: Dissertation
Full Text:: rhythms. These results suggest that AD- induced sleep/activity rhythm disruption is not due to

Creator:: Rakshit, Kuntol
Abstract:: Circadian clocks are endogenous molecular mechanisms that coordinate daily rhythms in gene expression, cellular activities, and physiological functions with external day/night cycles. Breakdown of circadian rhythms such as sleep/wake cycles is associated with the onset of several neurological diseases; however, it is not clear whether disruption of rhythms is a...
Resource Type:: Dissertation
Full Text:: locomotor activity rhythm. Transcriptional oscillations of four genes involved in the clock mechanism

Creator:: Hughes, Kelly L.
Abstract:: The endogenous circadian clock is an intracellular transcriptional feedback loop timing daily patterns of multiple biological rhythms within a 24-hour period. Disturbance in various rhythms leads to alteration of normal biological processes including cellular proliferation and tumor suppression. Endogenous circadian clock rhythms have been found to be disrupted in breast...
Resource Type:: Masters Thesis
Full Text:: breast cancer. These findings support the increasing evidence that circadian rhythm interference leads

Creator:: O'Malley, Kathleen G.
Abstract:: The genetic basis of adaptation is complex as many fitness-related traits are quantitative and likely influenced by multiple genes with variable effects across different selective environments. One important adaptation for anadromous Chinook salmon (Oncorhynchus tshawytscha) is the time at which individuals return to natal breeding sites within a reproductive season....
Resource Type:: Dissertation
Full Text:: of the circadian rhythm gene, Clock, from Chinook salmon (OtsClock1a and OtsClock1b). Phylogenetic

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