Index Catalog // ScholarsArchive@OSU

Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation

Creator:: Zhang, Yong
Abstract:: Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled signaling pathways. Prior research suggested that some isoforms of PLC-β may exist and function as dimers, but little is known about dimerization of PLC-β. Data from coimmunoprecipitation assays of differentially-tagged PLC-β constructs and sizeexclusion chromatography of native PLC-β support homodimerization...
Resource Type:: Dissertation
Full Text:: Phospholipase C-β Isozymes: Studies of Dimerization and Phosphatidylinositol 3,4,5-Trisphosphate Activation

Ascorbylation- the biological relevance of covalently bound ascorbic acid

Creator:: Kesinger, Nicholas G.
Abstract:: Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'. The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...
Resource Type:: Dissertation
Full Text:: approved: ___________________________ Dr. Jan F. Stevens Ascorbic acid, or vitamin C, is well known

Regulation of phospholipase C-beta isozymes by calmodulin

Creator:: McCullar, Jennifer Star
Abstract:: Phospholipase C-Jβ (PLCβ) is an important effector enzyme in G-protein-coupled signaling pathways. Activation of PLCβ by Gα and Gβy subunits has been fairly well characterized, but little is known about other protein interactions that may also regulate PLCβ function. A yeast two-hybrid screen of a mouse brain cDNA library with...
Resource Type:: Dissertation
Full Text:: . Title: Regulation of Phoshoplipase C-beta isozymes by Calmodulin A Abstract approved: Theresa M. Filtz

Role of Plc in the germination of Clostridium perfringens food poisoning isolate SM101

Creator:: Bond, Colton B.
Abstract:: Clostridium perfringens is the causative agent of gas gangrene and the 3rd most common cause of type A food borne disease in the United States. Critical to the pathogenicity of C. perfringens is the ability of this bacterium to produce highly resistant, metabolically dormant spores that can resume metabolic function...
Resource Type:: Masters Thesis
Full Text:: ), and pDP239 (mutator plasmid) were digested with BamHI at 37°C for 24 h. Digested DNA was run on a 1

SLC23A1, the gene encoding sodium-dependent vitamin C transport protein 1 (SVCT1) : regulation of transcription and its functional consequences

Creator:: Michels, Alexander Johannes
Abstract:: Vitamin C is an essential component of the human diet. Uptake of vitamin C in the cell is regulated by the function of sodium-dependent vitamin C transporters (SVCTs). SVCT1 (encoded by the SLC23A1 gene) is expressed in the colon, liver and kidney, where it plays a vital role in determining...
Resource Type:: Dissertation
Full Text:: Biophysics presented on September 19, 2007. Title: SLC23A1, the Gene Encoding Sodium-Dependent Vitamin C

Geneticist L.C. Dunn : politics, activism, and community

Creator:: Gormley, Melinda (Melinda Brooke)
Abstract:: L. C. Dunn (1893-1974) spent most of his scientific career conducting research in developmental genetics as a member of the Zoology Department at Columbia University in the City of New York. He had an accomplished scientific career researching mutations in mice, which earned him respect from other geneticists and scientists....
Resource Type:: Dissertation
Full Text:: : Mary Jo Nye L. C. Dunn (1893-1974) spent most of his scientific career conducting research

Quantifying C and N contents and isotope signatures of SOM pools in the H. J. Andrews DIRT plots

Creator:: Keirstead, Heath
Abstract:: The mechanisms governing short- and long-term belowground carbon dynamics need to be understood. As part of a larger project developed to assess the effect of quantity and quality of litter inputs on the rate of soil organic matter (SOM) formation, I examined SOM in the H. J. Andrews Detritus Input...
Resource Type:: Masters Thesis
Full Text:: ........................................................................................... 45 Quantifying C and N Contents and Isotope Signatures of SUM pools in the H. J. Andrews DIRT

Characterization of the mechanism and function of C₂H₂ zinc finger protein CTIP2 in the developmental processes

Creator:: Golonzhka, Olga
Abstract:: CTIP2 is a C2H2 zinc finger transcription factor that plays important yet poorly understood roles in mouse development. CTIP2 is known to be highly expressed in the central nervous system, skin and T lymphocytes during embryogenesis. CTIP2-null mice die perinatally of unknown causes and exhibit defects in multiple organ systems...
Resource Type:: Dissertation
Full Text:: ‐sheet and two histidines in the C‐terminal portion of the α‐helix. Zinc finger proteins usually

Hydrogen isotopic composition of C₃₇ alkenones and the ecology and physiology of coccolithophores

Creator:: Wolhowe, Matthew D.
Abstract:: A three-part study was conducted into the impact of physiological and ecological variables on the net isotopic fractionation of hydrogen, α[subscript K₃₇], expressed in C₃₇ alkenones. First, alkenone-producer production, abundance, and export were characterized in the summertime Gulf of California and Eastern Tropical North Pacific using compound-specific, labeled in situ...
Resource Type:: Dissertation
Full Text:: ) that αK37 may lend valuable context to studies of alkenone-producer ecology, and C) that alkenone δD

Time-Dependent Crack Growth Mechanisms in Alloy 617 at 800°C in Air

Creator:: Addison, Dylan, A.
Abstract:: Time-dependent crack growth mechanisms in Alloy 617 at 800°C in air were studied using compact tension samples machined in the L-T direction, cracked at temperature using an induction furnace and servo-hydraulic load frame. The application of different loading waveforms, including triangular, hold time, and sustained loading, were studied with relation...
Resource Type:: Masters Thesis
Full Text:: -Dependent Crack Growth Mechanisms in Alloy 617 at 800°C in Air Abstract approved

ScholarsArchive@OSU

Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation

Ascorbylation- the biological relevance of covalently bound ascorbic acid

Regulation of phospholipase C-beta isozymes by calmodulin

Role of Plc in the germination of Clostridium perfringens food poisoning isolate SM101

SLC23A1, the gene encoding sodium-dependent vitamin C transport protein 1 (SVCT1) : regulation of transcription and its functional consequences

Geneticist L.C. Dunn : politics, activism, and community

Quantifying C and N contents and isotope signatures of SOM pools in the H. J. Andrews DIRT plots

Characterization of the mechanism and function of C₂H₂ zinc finger protein CTIP2 in the developmental processes

Hydrogen isotopic composition of C₃₇ alkenones and the ecology and physiology of coccolithophores

Time-Dependent Crack Growth Mechanisms in Alloy 617 at 800°C in Air

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