Index Catalog // ScholarsArchive@OSU

The Response to Sulforaphane in Metastatic Prostate Cancer Cells

Creator:: Watson, Gregory
Abstract:: Sulforaphane is an isothiocyanate derived from cruciferous vegetables and has been under investigation as a cancer chemopreventive agent for over two decades. The compound is well tolerated and has been shown to slow cancer progression in several different pre-clinical models of carcinogenesis, such as of the lung, breast and colon....
Resource Type:: Dissertation
Full Text:: . Chapter 3. Gregory Watson, Samanthi Wickramasekara, Yufeng Fang, Zoraya Palomera-Sanchez, Claudia S

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Creator:: Huang, Lin
Abstract:: Oxidative stress is deﬁned as an imbalance that favors the production of reactive oxygen species (ROS) over an organism's antioxidant defense. ROS have the ability to damage, either directly or indirectly, biomolecules including DNA, proteins, carbohydrates, and lipids. Various pathological conditions and environmental and chronic diseases have been associated with...
Resource Type:: Dissertation
Full Text:: Abstract approved: ______________________________________________________ Claudia S. Maier

Label-free mass spectrometry-driven methods for elucidating adaptive responses of the hepatic mitochondrial proteome in an alcoholic fatty liver disease model

Creator:: Tzeng, Shin-Cheng
Abstract:: Alcoholic liver disease (ALD) continues to be one of the major public health problems in the United States and worldwide. Complicated by factors including gender, polymorphisms of alcohol-metabolizing enzymes, immunologic factors, exposures to other substances/drugs, hepatic viral infections, nutritional deficiencies, and obesity, ALD is a complex disease that requires a...
Resource Type:: Dissertation
Full Text:: Model Abstract approved: Dr. Claudia S. Maier Alcoholic liver disease (ALD

Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

Creator:: Nirudodhi, Sasidhar N.
Abstract:: Proteins are essential to all biological systems. Proteins participate in numerous cellular processes by interacting with other proteins, other metabolites and membranes in a dynamic environment. Studying the structural and conformational properties of proteins in the solution phase is necessary to understand their protein folding and interaction dynamics. This research...
Resource Type:: Dissertation
Full Text:: Conformational Dynamics in Large Protein Complexes Abstract approved: Claudia S. Maier Proteins are essential

Effects of small molecule ligands on the conformational dynamics of the Farnesoid X Receptor ligand binding domain (FXR-LBD)

Creator:: Yang, Liping
Abstract:: The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative function of FXR is governed by conformational changes of the ligand binding domain (LBD) upon ligand binding....
Resource Type:: Dissertation
Full Text:: : ______________________________________________________________ Dr. Claudia S. Maier

Development and Application of Mass Spectrometry-driven Methods for the Detection and Characterization of Biomolecular Signatures of Diseases

Creator:: Zandkarimi, Fereshteh
Abstract:: State-of-the-art, high-resolution mass spectrometry techniques for acquisition of metabolomic and lipidomic data coupled with advanced computational methods provide new opportunities for interpreting large and complex datasets and comprehending the underlying biological processes of diseases. Both metabolomics and lipidomics strive to obtain comprehensive analyses of small molecules, i.e., metabolites and lipids,...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ Claudia S. Maier State-of-the-art, high-resolution mass spectrometry techniques for

Comprehensive Analysis of The Brain Metabolome Using Mass Spectrometry in Conjunction with Data Analysis Techniques

Creator:: Khorani, Mona
Abstract:: Metabolomics has recently gained momentum in biomolecule research and complements the genomics and proteomics research space. Metabolomics strives to detect, identify, and quantify all metabolites present in biological samples. In particular, biomolecular analysis using ultra-performance liquid chromatography combined with mass spectrometry (UPLC-MS) has become increasingly important for metabolomic analyses. Similarly,...
Resource Type:: Dissertation
Full Text:: Claudia S. Maier Metabolomics has recently gained momentum in biomolecule research and complements

A Promising Approach for Preventing of Diet-Induced Obesity and Fatty Liver Using Tetrahydroxanthohumol, A Synthetic Derivative of Xanthohumol

Creator:: Zhang, Yang
Abstract:: Obesity and metabolic syndrome (MetS) affect over 1.9 billion adults and 12.7 million youth in the US. If all of today’s obese American youth become obese adults, the total societal costs over their lifetime may exceed $1.1 trillion. We show that feeding rodents a high-fat diet supplemented with xanthohumol (XN)...
Resource Type:: Dissertation
Full Text:: , Gerd Bobe, and Thomas J. Sharpton analyzed data. Kareem Raslan isolated fecal bacterial DNA. Johana S

A Mixed Methods Analysis of Philippine Labor Export Policies and Impacts on Overseas Filipino Workers

Creator:: O'Steen, Brianna
Abstract:: The Philippines’ labor export system is a complex web of policy instruments that have been amended, repealed, and refined over the last four decades. The laws along with the hortatory tools used to promote them have shaped the lives of millions of Filipinos, separating families across oceans. Temporary labor migration,...
Resource Type:: Dissertation
Full Text:: Workers. Abstract approved: Brent. S. Steel The Philippines’ labor export system is a

ScholarsArchive@OSU

The Response to Sulforaphane in Metastatic Prostate Cancer Cells

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Label-free mass spectrometry-driven methods for elucidating adaptive responses of the hepatic mitochondrial proteome in an alcoholic fatty liver disease model

Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

Effects of small molecule ligands on the conformational dynamics of the Farnesoid X Receptor ligand binding domain (FXR-LBD)

Development and Application of Mass Spectrometry-driven Methods for the Detection and Characterization of Biomolecular Signatures of Diseases

Comprehensive Analysis of The Brain Metabolome Using Mass Spectrometry in Conjunction with Data Analysis Techniques

A Promising Approach for Preventing of Diet-Induced Obesity and Fatty Liver Using Tetrahydroxanthohumol, A Synthetic Derivative of Xanthohumol

A Mixed Methods Analysis of Philippine Labor Export Policies and Impacts on Overseas Filipino Workers

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