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  • Biosynthesis and modification of the antibiotic enduracidin

    Creator:
    Goebel, Neal C.
    Abstract:
    The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...
    Resource Type:
    Dissertation
    Full Text:
    , mentoring and guidance provided by my advisor Dr. Mark Zabriskie. He has provided me with the opportunity

  • Evaluation of Bacterial F1FO-ATPase Inhibitors for Synergistic Effects

    Creator:
    Heppe, Kenan G.
    Abstract:
    F1FO-ATP synthase targeting antimicrobials apoptolidin 1 (A1), (+)-erythromefloquine, and oligomycin were tested in vitro for synergistic minimum inhibitory concentrations against Staphylococcus aureus. Synergy was strictly defined as inhibition by at most 25% the MIC of each participating drug. Ampicillin, with an MIC of 0.8 ug/mL, served as a negative control....
    Resource Type:
    Honors College Thesis
    Full Text:
    Dr. Mark Zabriskie F1FO-ATP synthase targeting antimicrobials apoptolidin 1 (A1), (+)-erythro

  • Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

    Creator:
    Blanchard, David, L.
    Abstract:
    L-pipecolic acid (L-PA) is the higher homolog of proline. It occurs naturally in many organisms, including primates, as an intermediate in lysine degradation. The pathway by which lysine is converted into L-pipecolic acid employs the enzyme Lpipecolate oxidase (L-PO), and appears to be tissue specific to the central nervous system...
    Resource Type:
    Dissertation
    Full Text:
    T. Mark Zabriskie L-pipecolic acid (L-PA) is the higher homolog of proline. It occurs

  • Activation, incorporation and modification of capreomycidine during viomycin biosynthesis

    Creator:
    Fei, Xiaobo
    Abstract:
    Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. The nonproteinogenic amino acid capreomycidine is the signature residue found in the tuberactinomycin family of antitubercular peptide antibiotics and an important element of the pharmacophore. Recombinant VioG, a single module peptide synthetase from the viomycin gene cluster cloned...
    Resource Type:
    Masters Thesis
    Full Text:
    : _______________________________________________ T. Mark Zabriskie Molecular genetic and enzymological techniques have been employed to

  • Discovery and identification of antibacterial agents for dental use

    Creator:
    Kirkpatrick, Adam G.
    Abstract:
    Dental disease is a very prevalent and costly disease in which the symptoms, not the disease, are currently being treated. The disease is caused by pathogenic oral bacteria, many of which are a part of the Mutans Streptococci. The objective of this thesis was to find a natural substance that...
    Resource Type:
    Honors College Thesis
    Full Text:
    approved: ______________________________________________________ Mark Zabriskie Dental

  • Formation and modification of enduracididine, a nonproteinogenic amino acid

    Creator:
    Tan, Ying
    Abstract:
    Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. In this thesis, we studied the formation and modification of the nonproteinogenic amino acid enduracididine (End), which exists in two important antibiotics, mannopeptimycins (MPPs) and enduracidin. Sequence analysis of the MPP gene cluster revealed that the product of...
    Resource Type:
    Masters Thesis
    Full Text:
    approved: _______________________________________________ T. Mark Zabriskie