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Filtering by: Creator Eisenberg, Rodney L. License Attribution 3.0 United States Resource Type Article

Simulated Evolution of Protein-Protein Interaction Networks with Realistic Topology

Creator:

Peterson, G. Jack, Pressé, Steve, Peterson, Kristin S., and Dill, Ken A.

Abstract:

We model the evolution of eukaryotic protein-protein interaction (PPI) networks. In our model, PPI networks evolve by two known biological mechanisms: (1) Gene duplication, which is followed by rapid diversification of duplicate interactions. (2) Neofunctionalization, in which a mutation leads to a new interaction with some other protein. Since many...

Resource Type:

Article

Full Text:

(l) distributions in human (green), yeast (blue), and fly (red). Heavy lines are the median values