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Filtering by: Creator Häse, Claudia C. License Attribution 3.0 United States Commencement Year Unknown

Malonate Inhibits Virulence Gene Expression in Vibrio cholerae

Creator:

Minato, Yusuke, Fassio, Sara R., and Häse, Claudia C.

Abstract:

We previously found that inhibition of the TCA cycle, either through mutations or chemical inhibition, increased toxT transcription in Vibrio cholerae. In this study, we found that the addition of malonate, an inhibitor of succinate dehydrogenase (SDH), decreased toxT transcription in V. cholerae, an observation inconsistent with the previous pattern...

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Vibrio cholerae Yusuke Minato1, Sara R. Fassio2, Claudia C. Häse1,2* 1 Department of Biomedical
Clostridium difficile Spore-Macrophage Interactions: Spore Survival

Creator:

Paredes-Sabja, Daniel, Cofre-Araneda, Glenda, Brito-Silva, Christian, Pizarro-Guajardo, Marjorie, and Sarker, Mahfuzur R.

Abstract:

Background: Clostridium difficile is the main cause of nosocomial infections including antibiotic associated diarrhea, pseudomembranous colitis and toxic megacolon. During the course of Clostridium difficile infections (CDI), C. difficile undergoes sporulation and releases spores to the colonic environment. The elevated relapse rates of CDI suggest that C. difficile spores has...

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Clostridium difficile infections (CDI), C. difficile undergoes sporulation and releases spores to the colonic