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Circadian Regulation of Glutathione Levels and Biosynthesis in Drosophila melanogaster

Creator:

Beaver, Laura M., Klichko, Vladimir I., Chow, Eileen S., Kotwica-Rolinska, Joanna, Williamson, Marisa, Orr, William C., Radyuk, Svetlana N., and Giebultowicz, Jadwiga M.

Abstract:

Circadian clocks generate daily rhythms in neuronal, physiological, and metabolic functions. Previous studies in mammals reported daily fluctuations in levels of the major endogenous antioxidant, glutathione (GSH), but the molecular mechanisms that govern such fluctuations remained unknown. To address this question, we used the model species Drosophila, which has a...

Resource Type:

Article

Full Text:

and Biosynthesis in Drosophila melanogaster Laura M. Beaver1¤a, Vladimir I. Klichko2, Eileen S. Chow1