Index Catalog // ScholarsArchive@OSU

The WAIS Divide deep ice core WD2014 chronology – Part 1: Methane synchronization (68–31 kaBP) and the gas age–ice age difference

Creator:: Buizert, C., Cuffey, K. M., Severinghaus, J. P., Baggenstos, D., Fudge, T. J., Steig, E. J., Markle, B. R., Winstrup, M., Rhodes, R. H., Brook, Edward J., Sowers, T. A., Clow, G. D., Cheng, H., Edwards, R. L., Sigl, M., McConnell, J. R., and Taylor, K. C.
Abstract:: The West Antarctic Ice Sheet Divide (WAIS Divide, WD) ice core is a newly drilled, high-accumulation deep ice core that provides Antarctic climate records of the past ~68 ka at unprecedented temporal resolution. The upper 2850 m (back to 31.2 ka BP) have been dated using annual-layer counting. Here we...
Resource Type:: Article

Evolutionary Biology for the 21st Century

Creator:: Losos, Jonathan B., Arnold, Stevan J., Bejerano, Gill, Brodie, E. D. III, Hibbett, David, Hoekstra, Hopi E., Mindell, David P., Monteiro, Antonia, Moritz, Craig, Orr, H. Allen, Petrov, Dmitri A., Renner, Susanne S., Ricklefs, Robert E., Soltis, Pamela S., and Turner, Thomas L.
Abstract:: We live in an exciting time for biology. Technological advances have made data collection easier and cheaper than we could ever have imagined just 10 years ago. We can now synthesize and analyze large data sets containing genomes, transcriptomes, proteomes, and multivariate phenotypes. At the same time, society's need for...
Resource Type:: Article
Full Text:: Century Jonathan B. Losos1*, Stevan J. Arnold2, Gill Bejerano3, E. D. Brodie III4, David Hibbett5, Hopi E

3,3'-Diindolylmethane Induces G₁ Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells

Creator:: Shorey, Lyndsey E., Hagman, Amanda M., Williams, David E., Ho, Emily, Dashwood, Roderick H., and Benninghoff, Abby D.
Abstract:: Certain bioactive food components, including indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) from cruciferous vegetables, have been shown to target cellular pathways regulating carcinogenesis. Previously, our laboratory showed that dietary I3C is an effective transplacental chemopreventive agent in a dibenzo[def,p]chrysene (DBC)-dependent model of murine T-cell lymphoblastic lymphoma. The primary objective of the...
Resource Type:: Article
Full Text:: pone.0034975 1..13 3,39-Diindolylmethane Induces G1 Arrest and

Mechanistic Insights into Validoxylamine A 7’-Phosphate Synthesis by VldE Using the Structure of the Entire Product Complex

Creator:: Cavalier, Michael C., Yim, Young-Sun, Asamizu, Shumpei, Neau, David, Almabruk, Khaled H., Mahmud, Taifo, and Lee, Yong-Hwan
Abstract:: The pseudo-glycosyltransferase VldE catalyzes non-glycosidic C-N coupling between an unsaturated cyclitol and a saturated aminocyclitol with the conservation of the stereochemical configuration of the substrates to form validoxylamine A 7'-phosphate, the biosynthetic precursor of the antibiotic validamycin A. To study the molecular basis of its mechanism, the three-dimensional structures of...
Resource Type:: Article
Full Text:: engineered production of validox- ylamine A. Chem Biol 13: 387–397. 3. Singh D, Seo MJ, Kwon HJ

Malonate Inhibits Virulence Gene Expression in Vibrio cholerae

Creator:: Minato, Yusuke, Fassio, Sara R., and Häse, Claudia C.
Abstract:: We previously found that inhibition of the TCA cycle, either through mutations or chemical inhibition, increased toxT transcription in Vibrio cholerae. In this study, we found that the addition of malonate, an inhibitor of succinate dehydrogenase (SDH), decreased toxT transcription in V. cholerae, an observation inconsistent with the previous pattern...
Resource Type:: Article
Full Text:: Expression in Vibrio cholerae. PLoS ONE 8(5): e63336. doi:10.1371/ journal.pone.0063336 Editor: Vasu D

Palaeo-sea-level and palaeo-ice-sheet databases: problems, strategies, and perspectives

Creator:: Düsterhus, André, Rovere, Alessio, Carlson, Anders E., Horton, Benjamin P., Klemann, Volker, Tarasov, Lev, Barlow, Natasha L. M., Bradwell, Tom, Clark, Jorie, Dutton, Andrea, Gehrels, W. Roland, Hibbert, Fiona D., Hijma, Marc P., Khan, Nicole, Kopp, Robert E., Sivan, Dorit, and Törnqvist, Torbjörn E.
Abstract:: Sea-level and ice-sheet databases have driven numerous advances in understanding the Earth system. We describe the challenges and offer best strategies that can be adopted to build self-consistent and standardised databases of geological and geochemical information used to archive palaeo-sea-levels and palaeo-ice-sheets. There are three phases in the development of...
Resource Type:: Article
Full Text:: , Tom Bradwell11, Jorie Clark5, Andrea Dutton12, W. Roland Gehrels13, Fiona D. Hibbert14, Marc P

How should the completeness and quality of curated nanomaterial data be evaluated?

Creator:: Marchese Robinson, Richard L., Lynch, Iseult, Peijnenburg, Willie, Rumble, John, Klaessig, Fred, Marquardt, Clarissa, Rauscher, Hubert, Puzyn, Tomasz, Purian, Ronit, Åberg, Christoffer, Karcher, Sandra, Vriens, Hanne, Hoet, Peter, Hoover, Mark D., Hendren, Christine Ogilvie, and Harper, Stacey L.
Abstract:: Nanotechnology is of increasing significance. Curation of nanomaterial data into electronic databases offers opportunities to better understand and predict nanomaterials’ behaviour. This supports innovation in, and regulation of, nanotechnology. It is commonly understood that curated data need to be sufficiently complete and of sufficient quality to serve their intended purpose....
Resource Type:: Article

Where to find 1.5 million yr old ice for the IPICS “Oldest-Ice” ice core

Creator:: Fischer, H., Severinghaus, J., Brook, Edward J., Wolff, E., Albert, M., Alemany, O., Arthern, R., Bentley, C., Blankenship, D., Chappellaz, J., Creyts, T., Dahl-Jensen, D., Dinn, M., Frezzotti, M., Fujita, S., Gallee, H., Hindmarsh, R., Hudspeth, D., Jugie, G., Kawamura, K., Lipenkov, V., Miller, H., Mulvaney, R., Parrenin, F., Pattyn, F., Ritz, C., Schwander, J., Steinhage, D., van Ommen, T., and Wilhelms, F.
Abstract:: The recovery of a 1.5 million yr long ice core from Antarctica represents a keystone of our understanding of Quaternary climate, the progression of glaciation over this time period and the role of greenhouse gas cycles in this progression. Here we tackle the question of where such ice may still...
Resource Type:: Article
Full Text:: . Brook3, E. Wolff4,*, M. Albert5, O. Alemany6, R. Arthern4, C. Bentley7, D. Blankenship8, J. Chappellaz6

The Level of Residual Dispersion Variation and the Power of Differential Expression Tests for RNA-Seq Data

Creator:: Mi, Gu and Di, Yanming
Abstract:: RNA-Sequencing (RNA-Seq) has been widely adopted for quantifying gene expression changes in comparative transcriptome analysis. For detecting differentially expressed genes, a variety of statistical methods based on the negative binomial (NB) distribution have been proposed. These methods differ in the ways they handle the NB nuisance parameters (i.e., the dispersion...
Resource Type:: Article
Full Text:: ): log ð�ijÞ ¼ f ðaij; aÞ; ð1Þ where i indexes genes and j indexes biological samples. For example, in

Endosperm Tolerance of Paternal Aneuploidy Allows Radiation Hybrid Mapping of the Wheat D-Genome and a Measure of γ Ray-Induced Chromosome Breaks

Creator:: Tiwari, Vijay K., Riera-Lizarazu, Oscar, Gunn, Hilary L., Lopez, KaSandra, Iqbal, M. Javed, Kianian, Shahryar F., and Leonard, Jeffrey M.
Abstract:: Physical mapping and genome sequencing are underway for the ≈17 Gb wheat genome. Physical mapping methods independent of meiotic recombination, such as radiation hybrid (RH) mapping, will aid precise anchoring of BAC contigs in the large regions of suppressed recombination in Triticeae genomes. Reports of endosperm development following pollination with...
Resource Type:: Article
Full Text:: addition to SSR and DArT markers, we assayed 13 D-genome specific ESTs, 5 insertion site-based

ScholarsArchive@OSU

The WAIS Divide deep ice core WD2014 chronology – Part 1: Methane synchronization (68–31 kaBP) and the gas age–ice age difference

Evolutionary Biology for the 21st Century

3,3'-Diindolylmethane Induces G₁ Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells

Mechanistic Insights into Validoxylamine A 7’-Phosphate Synthesis by VldE Using the Structure of the Entire Product Complex

Malonate Inhibits Virulence Gene Expression in Vibrio cholerae

Palaeo-sea-level and palaeo-ice-sheet databases: problems, strategies, and perspectives

How should the completeness and quality of curated nanomaterial data be evaluated?

Where to find 1.5 million yr old ice for the IPICS “Oldest-Ice” ice core

The Level of Residual Dispersion Variation and the Power of Differential Expression Tests for RNA-Seq Data

Endosperm Tolerance of Paternal Aneuploidy Allows Radiation Hybrid Mapping of the Wheat D-Genome and a Measure of γ Ray-Induced Chromosome Breaks

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