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  • Malonate Inhibits Virulence Gene Expression in Vibrio cholerae

    Creator:
    Minato, Yusuke, Fassio, Sara R., and Häse, Claudia C.
    Abstract:
    We previously found that inhibition of the TCA cycle, either through mutations or chemical inhibition, increased toxT transcription in Vibrio cholerae. In this study, we found that the addition of malonate, an inhibitor of succinate dehydrogenase (SDH), decreased toxT transcription in V. cholerae, an observation inconsistent with the previous pattern...
    Resource Type:
    Article
    Full Text:
    Vibrio cholerae Yusuke Minato1, Sara R. Fassio2, Claudia C. Häse1,2* 1 Department of Biomedical